Dimethyl fumarate inhibits osteoclasts via attenuation of reactive oxygen species signalling by augmented antioxidation

Bone destructive diseases are common worldwide and are caused by dysregulation of osteoclast formation and activation. During osteoclastogenesis, reactive oxygen species (ROS) play a role in the intracellular signalling triggered by receptor activator of nuclear factor‐κB ligand (RANKL) stimulation....

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Veröffentlicht in:	Journal of cellular and molecular medicine 2018-02, Vol.22 (2), p.1138-1147
Hauptverfasser:	Yamaguchi, Yuuki, Kanzaki, Hiroyuki, Katsumata, Yuta, Itohiya, Kanako, Fukaya, Sari, Miyamoto, Yutaka, Narimiya, Tsuyoshi, Wada, Satoshi, Nakamura, Yoshiki
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals antioxidant response Antioxidants Antioxidants - pharmacology Bone and Bones - drug effects Bone and Bones - pathology Calvaria CD11b Antigen Cell Death - drug effects Cell Nucleus - drug effects Cell Nucleus - metabolism Clinical trials Dimethyl dimethyl fumarate Dimethyl Fumarate - pharmacology Flow cytometry Gene transfer Genes, Reporter HO‐1 Intracellular Intracellular signalling Lipopolysaccharides Luciferases - metabolism Mice Neurodegenerative diseases NF-E2-Related Factor 2 - genetics NF-E2-Related Factor 2 - metabolism Nrf2 NRF2 protein Nuclei (cytology) Original osteoclast Osteoclastogenesis Osteoclasts Osteoclasts - drug effects Osteoclasts - metabolism Osteogenesis - drug effects Osteoporosis Osteoprogenitor cells Oxidative stress Periodontitis Polyphenols Promoter Regions, Genetic - genetics Protein Transport - drug effects RANK Ligand - pharmacology RAW 264.7 Cells Reactive oxygen species Reactive Oxygen Species - metabolism receptor activator of nuclear factor‐kB ligand Rheumatoid arthritis Rodents Signal Transduction - drug effects TRANCE protein Transcription Translocation
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