Bariatric Surgery–Induced Cardiac and Lipidomic Changes in Obesity‐Related Heart Failure with Preserved Ejection Fraction
Objective To determine the effects of gastric bypass on myocardial lipid deposition and function and the plasma lipidome in women with obesity and heart failure with preserved ejection fraction (HFpEF). Methods A primary cohort (N = 12) with HFpEF and obesity underwent echocardiography and magnetic...
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| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2018-02, Vol.26 (2), p.284-290 |
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| creator | Mikhalkova, Deana Holman, Sujata R. Jiang, Hui Saghir, Mohammed Novak, Eric Coggan, Andrew R. O'Connor, Robert Bashir, Adil Jamal, Ali Ory, Daniel S. Schaffer, Jean E. Eagon, J. Christopher Peterson, Linda R. |
| description | Objective
To determine the effects of gastric bypass on myocardial lipid deposition and function and the plasma lipidome in women with obesity and heart failure with preserved ejection fraction (HFpEF).
Methods
A primary cohort (N = 12) with HFpEF and obesity underwent echocardiography and magnetic resonance spectroscopy both before and 3 months and 6 months after bariatric surgery. Plasma lipidomic analysis was performed before surgery and 3 months after surgery in the primary cohort and were confirmed in a validation cohort (N = 22).
Results
After surgery‐induced weight loss, Minnesota Living with Heart Failure questionnaire scores, cardiac mass, and liver fat decreased (P |
| doi_str_mv | 10.1002/oby.22038 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5783730</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1992202995</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4438-a1c32b6220de8ada29cce31dbb4bb009c01fa9e035fe627d80dfbea302a6aa3a3</originalsourceid><addsrcrecordid>eNp1kc-KE0EQxhtR3DV68AWkwYsestt_JjPTF8ENG3chEPEP6Kmp7q5JOkx6st0zu-Qg-AiCb-iT2G7WoIKnKqhffdRXHyFPOTvhjInTzuxOhGCyvkeOuZJsXEn16f6hr_kReZTSmrGiZBP-kBwJJQopVXlMvpxB9NBHb-n7IS4x7n58_X4Z3GDR0SlE58FSCI7O_da7bpO56QrCEhP1gS4MJt_nlW_vsIU-r1wgxJ7OwLdDRHrj-xV9GzFhvM7D8zXa3neBziLcNo_JgwbahE_u6oh8nJ1_mF6M54s3l9PX87EtClmPgVspTJktOqzBgVDWouTOmMIYxpRlvAGFTE4aLEXlauYagyCZgBJAghyRV3vd7WA26CyGPkKrt9FvIO50B17_PQl-pZfdtZ5UtawkywIv7gRidzVg6vXGJ4ttCwG7IWmuqqqqRZE_PiLP_0HX3RBDtpcplT0IpSaZermnbOxSitgcjuFM_wpV51D1baiZffbn9Qfyd4oZON0DN77F3f-V9OLs817yJ2Q1sK8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1992202995</pqid></control><display><type>article</type><title>Bariatric Surgery–Induced Cardiac and Lipidomic Changes in Obesity‐Related Heart Failure with Preserved Ejection Fraction</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Mikhalkova, Deana ; Holman, Sujata R. ; Jiang, Hui ; Saghir, Mohammed ; Novak, Eric ; Coggan, Andrew R. ; O'Connor, Robert ; Bashir, Adil ; Jamal, Ali ; Ory, Daniel S. ; Schaffer, Jean E. ; Eagon, J. Christopher ; Peterson, Linda R.</creator><creatorcontrib>Mikhalkova, Deana ; Holman, Sujata R. ; Jiang, Hui ; Saghir, Mohammed ; Novak, Eric ; Coggan, Andrew R. ; O'Connor, Robert ; Bashir, Adil ; Jamal, Ali ; Ory, Daniel S. ; Schaffer, Jean E. ; Eagon, J. Christopher ; Peterson, Linda R.</creatorcontrib><description>Objective
To determine the effects of gastric bypass on myocardial lipid deposition and function and the plasma lipidome in women with obesity and heart failure with preserved ejection fraction (HFpEF).
Methods
A primary cohort (N = 12) with HFpEF and obesity underwent echocardiography and magnetic resonance spectroscopy both before and 3 months and 6 months after bariatric surgery. Plasma lipidomic analysis was performed before surgery and 3 months after surgery in the primary cohort and were confirmed in a validation cohort (N = 22).
Results
After surgery‐induced weight loss, Minnesota Living with Heart Failure questionnaire scores, cardiac mass, and liver fat decreased (P < 0.02, P < 0.001, and P = 0.007, respectively); echo‐derived e′ increased (P = 0.03), but cardiac fat was unchanged. Although weight loss was associated with decreases in many plasma ceramide and sphingolipid species, plasma lipid and cardiac function changes did not correlate.
Conclusions
Surgery‐induced weight loss in women with HFpEF and obesity was associated with improved symptoms, reverse cardiac remodeling, and improved relaxation. Although weight loss was associated with plasma sphingolipidome changes, cardiac function improvement was not associated with lipidomic or myocardial triglyceride changes. The results of this study suggest that gastric bypass ameliorates obesity‐related HFpEF and that cardiac fat deposition and lipidomic changes may not be critical to its pathogenesis.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.22038</identifier><identifier>PMID: 29243396</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Bariatric Surgery - adverse effects ; Cardiovascular disease ; Ejection fraction ; Family medical history ; Female ; Gastrointestinal surgery ; Heart - physiopathology ; Heart failure ; Heart Failure - etiology ; Heart Failure - pathology ; Heart surgery ; Humans ; Hypertension ; Lipids ; Male ; Metabolism ; Middle Aged ; Mortality ; Obesity ; Obesity - complications ; Obesity - pathology ; Plasma ; Questionnaires ; Stroke Volume - physiology ; Studies ; Weight control ; Womens health</subject><ispartof>Obesity (Silver Spring, Md.), 2018-02, Vol.26 (2), p.284-290</ispartof><rights>2017 The Obesity Society</rights><rights>2017 The Obesity Society.</rights><rights>Copyright Blackwell Publishing Ltd. Feb 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4438-a1c32b6220de8ada29cce31dbb4bb009c01fa9e035fe627d80dfbea302a6aa3a3</citedby><cites>FETCH-LOGICAL-c4438-a1c32b6220de8ada29cce31dbb4bb009c01fa9e035fe627d80dfbea302a6aa3a3</cites><orcidid>0000-0002-7723-8872 ; 0000-0001-8766-4552</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Foby.22038$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Foby.22038$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29243396$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mikhalkova, Deana</creatorcontrib><creatorcontrib>Holman, Sujata R.</creatorcontrib><creatorcontrib>Jiang, Hui</creatorcontrib><creatorcontrib>Saghir, Mohammed</creatorcontrib><creatorcontrib>Novak, Eric</creatorcontrib><creatorcontrib>Coggan, Andrew R.</creatorcontrib><creatorcontrib>O'Connor, Robert</creatorcontrib><creatorcontrib>Bashir, Adil</creatorcontrib><creatorcontrib>Jamal, Ali</creatorcontrib><creatorcontrib>Ory, Daniel S.</creatorcontrib><creatorcontrib>Schaffer, Jean E.</creatorcontrib><creatorcontrib>Eagon, J. Christopher</creatorcontrib><creatorcontrib>Peterson, Linda R.</creatorcontrib><title>Bariatric Surgery–Induced Cardiac and Lipidomic Changes in Obesity‐Related Heart Failure with Preserved Ejection Fraction</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Objective
To determine the effects of gastric bypass on myocardial lipid deposition and function and the plasma lipidome in women with obesity and heart failure with preserved ejection fraction (HFpEF).
Methods
A primary cohort (N = 12) with HFpEF and obesity underwent echocardiography and magnetic resonance spectroscopy both before and 3 months and 6 months after bariatric surgery. Plasma lipidomic analysis was performed before surgery and 3 months after surgery in the primary cohort and were confirmed in a validation cohort (N = 22).
Results
After surgery‐induced weight loss, Minnesota Living with Heart Failure questionnaire scores, cardiac mass, and liver fat decreased (P < 0.02, P < 0.001, and P = 0.007, respectively); echo‐derived e′ increased (P = 0.03), but cardiac fat was unchanged. Although weight loss was associated with decreases in many plasma ceramide and sphingolipid species, plasma lipid and cardiac function changes did not correlate.
Conclusions
Surgery‐induced weight loss in women with HFpEF and obesity was associated with improved symptoms, reverse cardiac remodeling, and improved relaxation. Although weight loss was associated with plasma sphingolipidome changes, cardiac function improvement was not associated with lipidomic or myocardial triglyceride changes. The results of this study suggest that gastric bypass ameliorates obesity‐related HFpEF and that cardiac fat deposition and lipidomic changes may not be critical to its pathogenesis.</description><subject>Bariatric Surgery - adverse effects</subject><subject>Cardiovascular disease</subject><subject>Ejection fraction</subject><subject>Family medical history</subject><subject>Female</subject><subject>Gastrointestinal surgery</subject><subject>Heart - physiopathology</subject><subject>Heart failure</subject><subject>Heart Failure - etiology</subject><subject>Heart Failure - pathology</subject><subject>Heart surgery</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Lipids</subject><subject>Male</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Obesity</subject><subject>Obesity - complications</subject><subject>Obesity - pathology</subject><subject>Plasma</subject><subject>Questionnaires</subject><subject>Stroke Volume - physiology</subject><subject>Studies</subject><subject>Weight control</subject><subject>Womens health</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc-KE0EQxhtR3DV68AWkwYsestt_JjPTF8ENG3chEPEP6Kmp7q5JOkx6st0zu-Qg-AiCb-iT2G7WoIKnKqhffdRXHyFPOTvhjInTzuxOhGCyvkeOuZJsXEn16f6hr_kReZTSmrGiZBP-kBwJJQopVXlMvpxB9NBHb-n7IS4x7n58_X4Z3GDR0SlE58FSCI7O_da7bpO56QrCEhP1gS4MJt_nlW_vsIU-r1wgxJ7OwLdDRHrj-xV9GzFhvM7D8zXa3neBziLcNo_JgwbahE_u6oh8nJ1_mF6M54s3l9PX87EtClmPgVspTJktOqzBgVDWouTOmMIYxpRlvAGFTE4aLEXlauYagyCZgBJAghyRV3vd7WA26CyGPkKrt9FvIO50B17_PQl-pZfdtZ5UtawkywIv7gRidzVg6vXGJ4ttCwG7IWmuqqqqRZE_PiLP_0HX3RBDtpcplT0IpSaZermnbOxSitgcjuFM_wpV51D1baiZffbn9Qfyd4oZON0DN77F3f-V9OLs817yJ2Q1sK8</recordid><startdate>201802</startdate><enddate>201802</enddate><creator>Mikhalkova, Deana</creator><creator>Holman, Sujata R.</creator><creator>Jiang, Hui</creator><creator>Saghir, Mohammed</creator><creator>Novak, Eric</creator><creator>Coggan, Andrew R.</creator><creator>O'Connor, Robert</creator><creator>Bashir, Adil</creator><creator>Jamal, Ali</creator><creator>Ory, Daniel S.</creator><creator>Schaffer, Jean E.</creator><creator>Eagon, J. Christopher</creator><creator>Peterson, Linda R.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7723-8872</orcidid><orcidid>https://orcid.org/0000-0001-8766-4552</orcidid></search><sort><creationdate>201802</creationdate><title>Bariatric Surgery–Induced Cardiac and Lipidomic Changes in Obesity‐Related Heart Failure with Preserved Ejection Fraction</title><author>Mikhalkova, Deana ; Holman, Sujata R. ; Jiang, Hui ; Saghir, Mohammed ; Novak, Eric ; Coggan, Andrew R. ; O'Connor, Robert ; Bashir, Adil ; Jamal, Ali ; Ory, Daniel S. ; Schaffer, Jean E. ; Eagon, J. Christopher ; Peterson, Linda R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4438-a1c32b6220de8ada29cce31dbb4bb009c01fa9e035fe627d80dfbea302a6aa3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Bariatric Surgery - adverse effects</topic><topic>Cardiovascular disease</topic><topic>Ejection fraction</topic><topic>Family medical history</topic><topic>Female</topic><topic>Gastrointestinal surgery</topic><topic>Heart - physiopathology</topic><topic>Heart failure</topic><topic>Heart Failure - etiology</topic><topic>Heart Failure - pathology</topic><topic>Heart surgery</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Lipids</topic><topic>Male</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Obesity</topic><topic>Obesity - complications</topic><topic>Obesity - pathology</topic><topic>Plasma</topic><topic>Questionnaires</topic><topic>Stroke Volume - physiology</topic><topic>Studies</topic><topic>Weight control</topic><topic>Womens health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mikhalkova, Deana</creatorcontrib><creatorcontrib>Holman, Sujata R.</creatorcontrib><creatorcontrib>Jiang, Hui</creatorcontrib><creatorcontrib>Saghir, Mohammed</creatorcontrib><creatorcontrib>Novak, Eric</creatorcontrib><creatorcontrib>Coggan, Andrew R.</creatorcontrib><creatorcontrib>O'Connor, Robert</creatorcontrib><creatorcontrib>Bashir, Adil</creatorcontrib><creatorcontrib>Jamal, Ali</creatorcontrib><creatorcontrib>Ory, Daniel S.</creatorcontrib><creatorcontrib>Schaffer, Jean E.</creatorcontrib><creatorcontrib>Eagon, J. Christopher</creatorcontrib><creatorcontrib>Peterson, Linda R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mikhalkova, Deana</au><au>Holman, Sujata R.</au><au>Jiang, Hui</au><au>Saghir, Mohammed</au><au>Novak, Eric</au><au>Coggan, Andrew R.</au><au>O'Connor, Robert</au><au>Bashir, Adil</au><au>Jamal, Ali</au><au>Ory, Daniel S.</au><au>Schaffer, Jean E.</au><au>Eagon, J. Christopher</au><au>Peterson, Linda R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bariatric Surgery–Induced Cardiac and Lipidomic Changes in Obesity‐Related Heart Failure with Preserved Ejection Fraction</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2018-02</date><risdate>2018</risdate><volume>26</volume><issue>2</issue><spage>284</spage><epage>290</epage><pages>284-290</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>Objective
To determine the effects of gastric bypass on myocardial lipid deposition and function and the plasma lipidome in women with obesity and heart failure with preserved ejection fraction (HFpEF).
Methods
A primary cohort (N = 12) with HFpEF and obesity underwent echocardiography and magnetic resonance spectroscopy both before and 3 months and 6 months after bariatric surgery. Plasma lipidomic analysis was performed before surgery and 3 months after surgery in the primary cohort and were confirmed in a validation cohort (N = 22).
Results
After surgery‐induced weight loss, Minnesota Living with Heart Failure questionnaire scores, cardiac mass, and liver fat decreased (P < 0.02, P < 0.001, and P = 0.007, respectively); echo‐derived e′ increased (P = 0.03), but cardiac fat was unchanged. Although weight loss was associated with decreases in many plasma ceramide and sphingolipid species, plasma lipid and cardiac function changes did not correlate.
Conclusions
Surgery‐induced weight loss in women with HFpEF and obesity was associated with improved symptoms, reverse cardiac remodeling, and improved relaxation. Although weight loss was associated with plasma sphingolipidome changes, cardiac function improvement was not associated with lipidomic or myocardial triglyceride changes. The results of this study suggest that gastric bypass ameliorates obesity‐related HFpEF and that cardiac fat deposition and lipidomic changes may not be critical to its pathogenesis.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>29243396</pmid><doi>10.1002/oby.22038</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-7723-8872</orcidid><orcidid>https://orcid.org/0000-0001-8766-4552</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1930-7381 |
| ispartof | Obesity (Silver Spring, Md.), 2018-02, Vol.26 (2), p.284-290 |
| issn | 1930-7381 1930-739X |
| language | eng |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Bariatric Surgery - adverse effects Cardiovascular disease Ejection fraction Family medical history Female Gastrointestinal surgery Heart - physiopathology Heart failure Heart Failure - etiology Heart Failure - pathology Heart surgery Humans Hypertension Lipids Male Metabolism Middle Aged Mortality Obesity Obesity - complications Obesity - pathology Plasma Questionnaires Stroke Volume - physiology Studies Weight control Womens health |
| title | Bariatric Surgery–Induced Cardiac and Lipidomic Changes in Obesity‐Related Heart Failure with Preserved Ejection Fraction |
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