Pharmacokinetics, Tissue Localization, Toxicity, and Treatment Efficacy in the First Small Animal (Rabbit) Model of Intra-Arterial Chemotherapy for Retinoblastoma

Current intra-arterial chemotherapy (IAC) drug regimens for retinoblastoma have ocular and vascular toxicities. No small-animal model of IAC exists to test drug efficacy and toxicity in vivo for IAC drug discovery. The purpose of this study was to develop a small-animal model of IAC and to analyze t...

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Veröffentlicht in:	Investigative ophthalmology & visual science 2018-01, Vol.59 (1), p.446-454
Hauptverfasser:	Daniels, Anthony B, Froehler, Michael T, Pierce, Janene M, Nunnally, Amy H, Calcutt, M Wade, Bridges, Thomas M, LaNeve, David C, Williams, Phillip E, Boyd, Kelli L, Reyzer, Michelle L, Lindsley, Craig W, Friedman, Debra L, Richmond, Ann
Format:	Artikel
Sprache:	eng
Schlagworte:	Anatomy and Pathology/Oncology Animals Antineoplastic Agents, Alkylating - pharmacokinetics Antineoplastic Agents, Alkylating - toxicity Disease Models, Animal Electroretinography Fluorescein Angiography Infusions, Intra-Arterial Melphalan - pharmacokinetics Melphalan - toxicity Ophthalmic Artery - drug effects Rabbits Retina - metabolism Retinal Neoplasms - drug therapy Retinal Neoplasms - metabolism Retinal Neoplasms - pathology Retinoblastoma - drug therapy Retinoblastoma - metabolism Retinoblastoma - pathology Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Tissue Distribution Treatment Outcome Vitreous Body - metabolism
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