Paracrine Effects of the Pluripotent Stem Cell-Derived Cardiac Myocytes Salvage the Injured Myocardium

RATIONALE:Cardiac myocytes derived from pluripotent stem cells have demonstrated the potential to mitigate damage of the infarcted myocardium and improve left ventricular ejection fraction (LVEF). However, the mechanism underlying the functional benefit is unclear. OBJECTIVE:To evaluate whether the...

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Veröffentlicht in:	Circulation research 2017-09, Vol.121 (6), p.e22-e36
Hauptverfasser:	Tachibana, Atsushi, Santoso, Michelle R, Mahmoudi, Morteza, Shukla, Praveen, Wang, Lei, Bennett, Mihoko, Goldstone, Andrew B, Wang, Mouer, Fukushi, Masahiro, Ebert, Antje D, Woo, Y Joseph, Rulifson, Eric, Yang, Phillip C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioluminescence Cardiomyocytes Cell Line Cells, Cultured Coronary artery Cytokines Cytokines - genetics Cytokines - metabolism Embryo cells Embryonic Stem Cells - cytology Embryonic Stem Cells - metabolism Embryonic Stem Cells - transplantation Embryos Gene expression Heart diseases Humans Immunohistochemistry Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Induced Pluripotent Stem Cells - transplantation Magnetic resonance imaging Manganese Mice Myocardial Infarction - therapy Myocardium Myocytes Myocytes, Cardiac - cytology Myocytes, Cardiac - metabolism Myocytes, Cardiac - transplantation NMR Nuclear magnetic resonance Paracrine Communication Paracrine signalling Phenotypes Pluripotency Secretions Stem cell transplantation Stem Cell Transplantation - methods Stem cells Ventricle
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