Epidemiology and clinical characteristics of human coronaviruses OC43, 229E, NL63, and HKU1: a study of hospitalized children with acute respiratory tract infection in Guangzhou, China
Human coronaviruses (HCoV) OC43, 229E, NL63, and HKU1 are common respiratory viruses which cause various respiratory diseases, including pneumonia. There is a paucity of evidence on the epidemiology and clinical manifestations of these four HCoV strains worldwide. We collected 11,399 throat swabs fr...
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| Veröffentlicht in: | European journal of clinical microbiology & infectious diseases 2018-02, Vol.37 (2), p.363-369 |
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| creator | Zeng, Zhi-Qi Chen, De-Hui Tan, Wei-Ping Qiu, Shu-Yan Xu, Duo Liang, Huan-Xi Chen, Mei-Xin Li, Xiao Lin, Zheng-Shi Liu, Wen-Kuan Zhou, Rong |
| description | Human coronaviruses (HCoV) OC43, 229E, NL63, and HKU1 are common respiratory viruses which cause various respiratory diseases, including pneumonia. There is a paucity of evidence on the epidemiology and clinical manifestations of these four HCoV strains worldwide. We collected 11,399 throat swabs from hospitalized children with acute respiratory tract infection from July 2009 to June 2016 in Guangzhou, China. These were tested for four strains of HCoV infection using real-time polymerase chain reaction (PCR). HCoV-positive patients were then tested for 11 other respiratory pathogens. 4.3% (489/11399) of patients were positive for HCoV, of which 3.0% were positive for OC43 (346/11399), 0.6% for 229E (65/11399), 0.5% for NL63 (60/11399), and 0.3% for HKU1 (38/11399). Patients aged 7–12 months had the highest prevalence of HCoV and OC43 when compared with other age groups (
p
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| doi_str_mv | 10.1007/s10096-017-3144-z |
| format | Article |
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p
< 0.001). The peak seasons of infection varied depending on the HCoV strain. Patients infected with a single strain of HCoV infection were less likely to present fever (≥ 38 °C) (
p
= 0.014) and more likely to present pulmonary rales (
p
= 0.043) than those co-infected with more than one HCoV strain or other respiratory pathogens. There were also significant differences in the prevalence of certain symptoms, including coughing (
p
= 0.032), pneumonia (
p
= 0.026), and abnormal pulmonary rales (
p
= 0.002) according to the strain of HCoV detected. This retrospective study of the prevalence of four HCoV strains and clinical signs among a large population of pediatric patients in a subtropical region of China provides further insight into the epidemiology and clinical features of HCoV.</description><identifier>ISSN: 0934-9723</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-017-3144-z</identifier><identifier>PMID: 29214503</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Biomedical and Life Sciences ; Biomedicine ; Children ; Coronaviridae ; Coronaviruses ; Epidemiology ; Fever ; Infections ; Internal Medicine ; Medical Microbiology ; Original ; Original Article ; Pathogens ; Patients ; Pneumonia ; Polymerase chain reaction ; Respiratory diseases ; Respiratory tract ; Respiratory tract diseases ; Respiratory tract infection</subject><ispartof>European journal of clinical microbiology & infectious diseases, 2018-02, Vol.37 (2), p.363-369</ispartof><rights>The Author(s) 2017</rights><rights>European Journal of Clinical Microbiology & Infectious Diseases is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-b060e5445b284363058fda70143da01d00754f90d82eb4cf54bb86ac2267e7933</citedby><cites>FETCH-LOGICAL-c470t-b060e5445b284363058fda70143da01d00754f90d82eb4cf54bb86ac2267e7933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10096-017-3144-z$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10096-017-3144-z$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29214503$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zeng, Zhi-Qi</creatorcontrib><creatorcontrib>Chen, De-Hui</creatorcontrib><creatorcontrib>Tan, Wei-Ping</creatorcontrib><creatorcontrib>Qiu, Shu-Yan</creatorcontrib><creatorcontrib>Xu, Duo</creatorcontrib><creatorcontrib>Liang, Huan-Xi</creatorcontrib><creatorcontrib>Chen, Mei-Xin</creatorcontrib><creatorcontrib>Li, Xiao</creatorcontrib><creatorcontrib>Lin, Zheng-Shi</creatorcontrib><creatorcontrib>Liu, Wen-Kuan</creatorcontrib><creatorcontrib>Zhou, Rong</creatorcontrib><title>Epidemiology and clinical characteristics of human coronaviruses OC43, 229E, NL63, and HKU1: a study of hospitalized children with acute respiratory tract infection in Guangzhou, China</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>Human coronaviruses (HCoV) OC43, 229E, NL63, and HKU1 are common respiratory viruses which cause various respiratory diseases, including pneumonia. There is a paucity of evidence on the epidemiology and clinical manifestations of these four HCoV strains worldwide. We collected 11,399 throat swabs from hospitalized children with acute respiratory tract infection from July 2009 to June 2016 in Guangzhou, China. These were tested for four strains of HCoV infection using real-time polymerase chain reaction (PCR). HCoV-positive patients were then tested for 11 other respiratory pathogens. 4.3% (489/11399) of patients were positive for HCoV, of which 3.0% were positive for OC43 (346/11399), 0.6% for 229E (65/11399), 0.5% for NL63 (60/11399), and 0.3% for HKU1 (38/11399). Patients aged 7–12 months had the highest prevalence of HCoV and OC43 when compared with other age groups (
p
< 0.001). The peak seasons of infection varied depending on the HCoV strain. Patients infected with a single strain of HCoV infection were less likely to present fever (≥ 38 °C) (
p
= 0.014) and more likely to present pulmonary rales (
p
= 0.043) than those co-infected with more than one HCoV strain or other respiratory pathogens. There were also significant differences in the prevalence of certain symptoms, including coughing (
p
= 0.032), pneumonia (
p
= 0.026), and abnormal pulmonary rales (
p
= 0.002) according to the strain of HCoV detected. This retrospective study of the prevalence of four HCoV strains and clinical signs among a large population of pediatric patients in a subtropical region of China provides further insight into the epidemiology and clinical features of HCoV.</description><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Children</subject><subject>Coronaviridae</subject><subject>Coronaviruses</subject><subject>Epidemiology</subject><subject>Fever</subject><subject>Infections</subject><subject>Internal Medicine</subject><subject>Medical Microbiology</subject><subject>Original</subject><subject>Original Article</subject><subject>Pathogens</subject><subject>Patients</subject><subject>Pneumonia</subject><subject>Polymerase chain reaction</subject><subject>Respiratory diseases</subject><subject>Respiratory tract</subject><subject>Respiratory tract diseases</subject><subject>Respiratory tract 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B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180201</creationdate><title>Epidemiology and clinical characteristics of human coronaviruses OC43, 229E, NL63, and HKU1: a study of hospitalized children with acute respiratory tract infection in Guangzhou, China</title><author>Zeng, Zhi-Qi ; Chen, De-Hui ; Tan, Wei-Ping ; Qiu, Shu-Yan ; Xu, Duo ; Liang, Huan-Xi ; Chen, Mei-Xin ; Li, Xiao ; Lin, Zheng-Shi ; Liu, Wen-Kuan ; Zhou, Rong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-b060e5445b284363058fda70143da01d00754f90d82eb4cf54bb86ac2267e7933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Children</topic><topic>Coronaviridae</topic><topic>Coronaviruses</topic><topic>Epidemiology</topic><topic>Fever</topic><topic>Infections</topic><topic>Internal Medicine</topic><topic>Medical Microbiology</topic><topic>Original</topic><topic>Original Article</topic><topic>Pathogens</topic><topic>Patients</topic><topic>Pneumonia</topic><topic>Polymerase chain 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Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of clinical microbiology & infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zeng, Zhi-Qi</au><au>Chen, De-Hui</au><au>Tan, Wei-Ping</au><au>Qiu, Shu-Yan</au><au>Xu, Duo</au><au>Liang, Huan-Xi</au><au>Chen, Mei-Xin</au><au>Li, Xiao</au><au>Lin, Zheng-Shi</au><au>Liu, Wen-Kuan</au><au>Zhou, Rong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epidemiology and clinical characteristics of human coronaviruses OC43, 229E, NL63, and HKU1: a study of hospitalized children with acute respiratory tract infection in Guangzhou, China</atitle><jtitle>European journal of clinical microbiology & infectious diseases</jtitle><stitle>Eur J Clin Microbiol Infect Dis</stitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>37</volume><issue>2</issue><spage>363</spage><epage>369</epage><pages>363-369</pages><issn>0934-9723</issn><eissn>1435-4373</eissn><abstract>Human coronaviruses (HCoV) OC43, 229E, NL63, and HKU1 are common respiratory viruses which cause various respiratory diseases, including pneumonia. There is a paucity of evidence on the epidemiology and clinical manifestations of these four HCoV strains worldwide. We collected 11,399 throat swabs from hospitalized children with acute respiratory tract infection from July 2009 to June 2016 in Guangzhou, China. These were tested for four strains of HCoV infection using real-time polymerase chain reaction (PCR). HCoV-positive patients were then tested for 11 other respiratory pathogens. 4.3% (489/11399) of patients were positive for HCoV, of which 3.0% were positive for OC43 (346/11399), 0.6% for 229E (65/11399), 0.5% for NL63 (60/11399), and 0.3% for HKU1 (38/11399). Patients aged 7–12 months had the highest prevalence of HCoV and OC43 when compared with other age groups (
p
< 0.001). The peak seasons of infection varied depending on the HCoV strain. Patients infected with a single strain of HCoV infection were less likely to present fever (≥ 38 °C) (
p
= 0.014) and more likely to present pulmonary rales (
p
= 0.043) than those co-infected with more than one HCoV strain or other respiratory pathogens. There were also significant differences in the prevalence of certain symptoms, including coughing (
p
= 0.032), pneumonia (
p
= 0.026), and abnormal pulmonary rales (
p
= 0.002) according to the strain of HCoV detected. This retrospective study of the prevalence of four HCoV strains and clinical signs among a large population of pediatric patients in a subtropical region of China provides further insight into the epidemiology and clinical features of HCoV.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>29214503</pmid><doi>10.1007/s10096-017-3144-z</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | European journal of clinical microbiology & infectious diseases, 2018-02, Vol.37 (2), p.363-369 |
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| language | eng |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Biomedical and Life Sciences Biomedicine Children Coronaviridae Coronaviruses Epidemiology Fever Infections Internal Medicine Medical Microbiology Original Original Article Pathogens Patients Pneumonia Polymerase chain reaction Respiratory diseases Respiratory tract Respiratory tract diseases Respiratory tract infection |
| title | Epidemiology and clinical characteristics of human coronaviruses OC43, 229E, NL63, and HKU1: a study of hospitalized children with acute respiratory tract infection in Guangzhou, China |
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