GM-CSF promotes chronic disability in EAE by altering the composition of CNS myeloid cells, but is dispensable for disease induction

Granulocyte-macrophage colony-stimulating factor (GM-CSF) has been portrayed as a critical cytokine in the pathogenesis of experimental autoimmune encephalomyelitis (EAE) and, ostensibly, in multiple sclerosis. C57BL/6 mice deficient in GM-CSF are resistant to EAE induced by immunization with the 35...

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Veröffentlicht in:	The Journal of immunology (1950) 2017-12, Vol.200 (3), p.966-973
Hauptverfasser:	Duncker, Patrick C., Stoolman, Joshua S., Huber, Amanda K., Segal, Benjamin M.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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