Closure of Varicella-Zoster Virus–Containing Vaccines Pregnancy Registry — United States, 2013
Vaccines that contain live attenuated varicella-zoster virus (VZV) (Varivax, ProQuad, and Zostavax [all products of Merck & Co., Inc.]) are contraindicated during pregnancy. To monitor the pregnancy outcomes of women inadvertently vaccinated with VZV-containing vaccines immediately before or dur...
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description | Vaccines that contain live attenuated varicella-zoster virus (VZV) (Varivax, ProQuad, and Zostavax [all products of Merck & Co., Inc.]) are contraindicated during pregnancy. To monitor the pregnancy outcomes of women inadvertently vaccinated with VZV-containing vaccines immediately before or during pregnancy, Merck and CDC established the Merck/CDC Pregnancy Registry for VZV-Containing Vaccines in 1995. This report updates previously published summaries of registry data, provides the rationale for the closure of the registry, and describes plans for continued monitoring of the safety of these vaccines when inadvertently administered to pregnant women or immediately before pregnancy. From inception of the registry in 1995 through March 2012, no cases of congenital varicella syndrome and no increased prevalence of other birth defects have been detected among women vaccinated within 3 months before or during pregnancy. Although a small risk for congenital varicella syndrome cannot be ruled out, the number of exposures being registered each year (approximately two varicella-susceptible women exposed during the high-risk period for congenital varicella syndrome) is now too low to improve on the current estimate of the risk. |
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To monitor the pregnancy outcomes of women inadvertently vaccinated with VZV-containing vaccines immediately before or during pregnancy, Merck and CDC established the Merck/CDC Pregnancy Registry for VZV-Containing Vaccines in 1995. This report updates previously published summaries of registry data, provides the rationale for the closure of the registry, and describes plans for continued monitoring of the safety of these vaccines when inadvertently administered to pregnant women or immediately before pregnancy. From inception of the registry in 1995 through March 2012, no cases of congenital varicella syndrome and no increased prevalence of other birth defects have been detected among women vaccinated within 3 months before or during pregnancy. Although a small risk for congenital varicella syndrome cannot be ruled out, the number of exposures being registered each year (approximately two varicella-susceptible women exposed during the high-risk period for congenital varicella syndrome) is now too low to improve on the current estimate of the risk.</description><identifier>ISSN: 0149-2195</identifier><identifier>EISSN: 1545-861X</identifier><identifier>PMID: 25144545</identifier><language>eng</language><publisher>United States: Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention (CDC), U.S. Department of Health and Human Services</publisher><subject>Chickenpox ; Chickenpox vaccine ; Female ; Herpes viruses ; Herpes zoster ; Herpes Zoster - prevention & control ; Herpes zoster vaccine ; Herpes Zoster Vaccine - administration & dosage ; Herpes Zoster Vaccine - adverse effects ; Herpesvirus 3, Human - immunology ; Humans ; Immunization ; Maternal & child health ; Medication administration ; Pharmaceutical industry ; Pregnancy ; Pregnancy Outcome ; Pregnant women ; Registries ; Safety ; Shingles (Disease) ; United States ; Vaccination ; Vaccines ; Varicella zoster encephalitis ; Varicella-zoster virus ; Virus diseases ; Virus diseases in pregnancy</subject><ispartof>MMWR. Morbidity and mortality weekly report, 2014-08, Vol.63 (33), p.732-733</ispartof><rights>COPYRIGHT 2014 U.S. Government Printing Office</rights><rights>Copyright U.S. Center for Disease Control Aug 22, 2014</rights><rights>2014</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/24855305$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/24855305$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25144545$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marin, Mona</creatorcontrib><creatorcontrib>Willis, English D.</creatorcontrib><creatorcontrib>Marko, Ann</creatorcontrib><creatorcontrib>Rasmussen, Sonja A.</creatorcontrib><creatorcontrib>Bialek, Stephanie R.</creatorcontrib><creatorcontrib>Dana, Adrian</creatorcontrib><creatorcontrib>Centers for Disease Control and Prevention (CDC)</creatorcontrib><title>Closure of Varicella-Zoster Virus–Containing Vaccines Pregnancy Registry — United States, 2013</title><title>MMWR. Morbidity and mortality weekly report</title><addtitle>MMWR Morb Mortal Wkly Rep</addtitle><description>Vaccines that contain live attenuated varicella-zoster virus (VZV) (Varivax, ProQuad, and Zostavax [all products of Merck & Co., Inc.]) are contraindicated during pregnancy. To monitor the pregnancy outcomes of women inadvertently vaccinated with VZV-containing vaccines immediately before or during pregnancy, Merck and CDC established the Merck/CDC Pregnancy Registry for VZV-Containing Vaccines in 1995. This report updates previously published summaries of registry data, provides the rationale for the closure of the registry, and describes plans for continued monitoring of the safety of these vaccines when inadvertently administered to pregnant women or immediately before pregnancy. From inception of the registry in 1995 through March 2012, no cases of congenital varicella syndrome and no increased prevalence of other birth defects have been detected among women vaccinated within 3 months before or during pregnancy. Although a small risk for congenital varicella syndrome cannot be ruled out, the number of exposures being registered each year (approximately two varicella-susceptible women exposed during the high-risk period for congenital varicella syndrome) is now too low to improve on the current estimate of the risk.</description><subject>Chickenpox</subject><subject>Chickenpox vaccine</subject><subject>Female</subject><subject>Herpes viruses</subject><subject>Herpes zoster</subject><subject>Herpes Zoster - prevention & control</subject><subject>Herpes zoster vaccine</subject><subject>Herpes Zoster Vaccine - administration & dosage</subject><subject>Herpes Zoster Vaccine - adverse effects</subject><subject>Herpesvirus 3, Human - immunology</subject><subject>Humans</subject><subject>Immunization</subject><subject>Maternal & child health</subject><subject>Medication administration</subject><subject>Pharmaceutical industry</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Pregnant women</subject><subject>Registries</subject><subject>Safety</subject><subject>Shingles (Disease)</subject><subject>United States</subject><subject>Vaccination</subject><subject>Vaccines</subject><subject>Varicella zoster encephalitis</subject><subject>Varicella-zoster virus</subject><subject>Virus diseases</subject><subject>Virus diseases in pregnancy</subject><issn>0149-2195</issn><issn>1545-861X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0t1qFDEUAOChKO1a-whKUBAvHMnvTOZGKIt_UFDsD8WbkM2cmU2ZTdYkI-xd30GfsE9i1q1tVza5COR8OSc5ZK-YEMFFKSty-aiYYMKbkpJGHBRPYrzC68HwfnFABeE8w0kxmw4-jgGQ79CFDtbAMOjyu48JArqwYYw317-m3iVtnXV9NsZYBxF9DdA77cwKfYPexhRW6Ob6Nzp3NkGLTpNOEN8gigl7Wjzu9BDh6HY9LM4_vD-bfipPvnz8PD0-KXsueSqNFkBIW0lWdzM54zVo03JCmZaat6yVRFPd5AfIujVUYE5wRWiHG8opFaJmh8W7Td7lOFtAa8CloAe1DHahw0p5bdV2xNm56v1PJeq64UzkBC9uEwT_Y4SYVIClDykqkvNjLnPpjF7_hxY2_u2aAz-uaZWfgGnNMn25ob0eQFnX-VzWrLk6ZpIIKStWZVXuUD04yHf0Djqbt7f82x0-zxYW1uw88OrBgTnoIc2jH8ZkvYvb8PnDBt517t9vyeDZBlzF5MN9nEshGBbsDySzxDc</recordid><startdate>20140822</startdate><enddate>20140822</enddate><creator>Marin, Mona</creator><creator>Willis, English D.</creator><creator>Marko, Ann</creator><creator>Rasmussen, Sonja A.</creator><creator>Bialek, Stephanie R.</creator><creator>Dana, Adrian</creator><general>Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention (CDC), U.S. Department of Health and Human Services</general><general>U.S. Government Printing Office</general><general>U.S. Center for Disease Control</general><general>U.S. Centers for Disease Control</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7U9</scope><scope>H94</scope><scope>0-V</scope><scope>3V.</scope><scope>4T-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>88F</scope><scope>88J</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M1Q</scope><scope>M2O</scope><scope>M2R</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>S0X</scope><scope>5PM</scope></search><sort><creationdate>20140822</creationdate><title>Closure of Varicella-Zoster Virus–Containing Vaccines Pregnancy Registry — United States, 2013</title><author>Marin, Mona ; 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Morbidity and mortality weekly report</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marin, Mona</au><au>Willis, English D.</au><au>Marko, Ann</au><au>Rasmussen, Sonja A.</au><au>Bialek, Stephanie R.</au><au>Dana, Adrian</au><aucorp>Centers for Disease Control and Prevention (CDC)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Closure of Varicella-Zoster Virus–Containing Vaccines Pregnancy Registry — United States, 2013</atitle><jtitle>MMWR. 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From inception of the registry in 1995 through March 2012, no cases of congenital varicella syndrome and no increased prevalence of other birth defects have been detected among women vaccinated within 3 months before or during pregnancy. Although a small risk for congenital varicella syndrome cannot be ruled out, the number of exposures being registered each year (approximately two varicella-susceptible women exposed during the high-risk period for congenital varicella syndrome) is now too low to improve on the current estimate of the risk.</abstract><cop>United States</cop><pub>Center for Surveillance, Epidemiology, and Laboratory Services, Centers for Disease Control and Prevention (CDC), U.S. Department of Health and Human Services</pub><pmid>25144545</pmid><tpages>2</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Chickenpox Chickenpox vaccine Female Herpes viruses Herpes zoster Herpes Zoster - prevention & control Herpes zoster vaccine Herpes Zoster Vaccine - administration & dosage Herpes Zoster Vaccine - adverse effects Herpesvirus 3, Human - immunology Humans Immunization Maternal & child health Medication administration Pharmaceutical industry Pregnancy Pregnancy Outcome Pregnant women Registries Safety Shingles (Disease) United States Vaccination Vaccines Varicella zoster encephalitis Varicella-zoster virus Virus diseases Virus diseases in pregnancy |
title | Closure of Varicella-Zoster Virus–Containing Vaccines Pregnancy Registry — United States, 2013 |
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