The relationship between coronary slow flow phenomenon and urotensin-II: A prospective and controlled study
The underlying mechanism of coronary slow flow (CSF) has not yet been clarified, although many studies have been conducted to understand its pathophysiology. In this study, we investigated the role of a very potent vasoconstrictor, urotensin-II (UII), in the pathophysiology of CSF. This prospective...
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| Veröffentlicht in: | Anatolian journal of cardiology 2015-06, Vol.15 (6), p.475-479 |
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| creator | Zengin, Halit Erbay, Ali Rıza Okuyucu, Ali Alaçam, Hasan Yüksel, Serkan Meriç, Murat Soylu, Korhan Gedikli, Ömer Murat, Naci Gülel, Okan Demircan, Sabri Akın, Filiz Yılmaz, Özcan Şahin, Mahmut |
| description | The underlying mechanism of coronary slow flow (CSF) has not yet been clarified, although many studies have been conducted to understand its pathophysiology. In this study, we investigated the role of a very potent vasoconstrictor, urotensin-II (UII), in the pathophysiology of CSF. This prospective and controlled investigation aimed to evaluate the association between CSF and serum levels of UII.
Our study included 32 patients with slow flow in any coronary artery and 32 patients with normal coronary arteries. Coronary flow was calculated using the Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC) method, and CSF was defined as TFC ≥39 for the left anterior descending artery, TFC ≥27 for the circumflex coronary artery, and TFC ≥24 for the right coronary artery. UII levels in blood samples obtained from both groups were measured by enzyme-linked immunosorbent assay (ELISA) method.
UII levels were significantly higher in the CSF group than in the control group [122 pg/mL (71-831), 95 pg/mL (21-635), respectively; p |
| doi_str_mv | 10.5152/akd.2014.5481 |
| format | Article |
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Our study included 32 patients with slow flow in any coronary artery and 32 patients with normal coronary arteries. Coronary flow was calculated using the Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC) method, and CSF was defined as TFC ≥39 for the left anterior descending artery, TFC ≥27 for the circumflex coronary artery, and TFC ≥24 for the right coronary artery. UII levels in blood samples obtained from both groups were measured by enzyme-linked immunosorbent assay (ELISA) method.
UII levels were significantly higher in the CSF group than in the control group [122 pg/mL (71-831), 95 pg/mL (21-635), respectively; p<0.001]. High-density lipoprotein (HDL) levels were lower in the CSF group, and leukocyte counts were significantly higher. A positive correlation between UII and mean TFC (r=0.524, p=0.002) was found in the CSF group. The multivariate logistic regression analysis determined that UII, HDL, and cigarette smoking were independent indicators in predicting CSF (OR=1.010, 95% confidence interval 1.002-1014, p=0.019; OR=0.927, 95% confidence interval 0.869-0.988, p=0.019; OR=5.755, 95% confidence interval 1.272-26.041, p=0.021, respectively).
Serum UII levels were found to be significantly higher in the CSF group, suggesting that UII may be one of the underlying factors in the pathogenesis of CSF.</description><identifier>ISSN: 2149-2263</identifier><identifier>EISSN: 2149-2271</identifier><identifier>DOI: 10.5152/akd.2014.5481</identifier><identifier>PMID: 25430414</identifier><language>eng</language><publisher>Turkey: Kare Publishing</publisher><subject>Biomarkers - blood ; Blood Flow Velocity ; Case-Control Studies ; Coronary Circulation ; Coronary Vessels ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Myocardial Ischemia - blood ; Myocardial Ischemia - diagnostic imaging ; Myocardial Ischemia - physiopathology ; Original Investigation ; Prospective Studies ; Radiography ; Urotensins - blood</subject><ispartof>Anatolian journal of cardiology, 2015-06, Vol.15 (6), p.475-479</ispartof><rights>Copyright Aves Yayincilik Ltd. STI. Jun 2015</rights><rights>Copyright © 2015 Turkish Society of Cardiology 2015</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-dee0e90002cdbdb2c1695257f9b9be8fafe1b839fecb73895f8c3da63661756e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779140/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5779140/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25430414$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zengin, Halit</creatorcontrib><creatorcontrib>Erbay, Ali Rıza</creatorcontrib><creatorcontrib>Okuyucu, Ali</creatorcontrib><creatorcontrib>Alaçam, Hasan</creatorcontrib><creatorcontrib>Yüksel, Serkan</creatorcontrib><creatorcontrib>Meriç, Murat</creatorcontrib><creatorcontrib>Soylu, Korhan</creatorcontrib><creatorcontrib>Gedikli, Ömer</creatorcontrib><creatorcontrib>Murat, Naci</creatorcontrib><creatorcontrib>Gülel, Okan</creatorcontrib><creatorcontrib>Demircan, Sabri</creatorcontrib><creatorcontrib>Akın, Filiz</creatorcontrib><creatorcontrib>Yılmaz, Özcan</creatorcontrib><creatorcontrib>Şahin, Mahmut</creatorcontrib><title>The relationship between coronary slow flow phenomenon and urotensin-II: A prospective and controlled study</title><title>Anatolian journal of cardiology</title><addtitle>Anatol J Cardiol</addtitle><description>The underlying mechanism of coronary slow flow (CSF) has not yet been clarified, although many studies have been conducted to understand its pathophysiology. In this study, we investigated the role of a very potent vasoconstrictor, urotensin-II (UII), in the pathophysiology of CSF. This prospective and controlled investigation aimed to evaluate the association between CSF and serum levels of UII.
Our study included 32 patients with slow flow in any coronary artery and 32 patients with normal coronary arteries. Coronary flow was calculated using the Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC) method, and CSF was defined as TFC ≥39 for the left anterior descending artery, TFC ≥27 for the circumflex coronary artery, and TFC ≥24 for the right coronary artery. UII levels in blood samples obtained from both groups were measured by enzyme-linked immunosorbent assay (ELISA) method.
UII levels were significantly higher in the CSF group than in the control group [122 pg/mL (71-831), 95 pg/mL (21-635), respectively; p<0.001]. High-density lipoprotein (HDL) levels were lower in the CSF group, and leukocyte counts were significantly higher. A positive correlation between UII and mean TFC (r=0.524, p=0.002) was found in the CSF group. The multivariate logistic regression analysis determined that UII, HDL, and cigarette smoking were independent indicators in predicting CSF (OR=1.010, 95% confidence interval 1.002-1014, p=0.019; OR=0.927, 95% confidence interval 0.869-0.988, p=0.019; OR=5.755, 95% confidence interval 1.272-26.041, p=0.021, respectively).
Serum UII levels were found to be significantly higher in the CSF group, suggesting that UII may be one of the underlying factors in the pathogenesis of CSF.</description><subject>Biomarkers - blood</subject><subject>Blood Flow Velocity</subject><subject>Case-Control Studies</subject><subject>Coronary Circulation</subject><subject>Coronary Vessels</subject><subject>Female</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Ischemia - blood</subject><subject>Myocardial Ischemia - diagnostic imaging</subject><subject>Myocardial Ischemia - physiopathology</subject><subject>Original Investigation</subject><subject>Prospective Studies</subject><subject>Radiography</subject><subject>Urotensins - blood</subject><issn>2149-2263</issn><issn>2149-2271</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkUFrFTEUhYMottQu3UrAjZt55iaTzMSFUIrVB4Vu6jpkkju-aeclYzLT0n9vpq0P7SLJhftxOCeHkPfANhIk_2xv_YYzqDeybuEVOeZQ64rzBl4fZiWOyGnON4wxaEQLoN6SIy5rwWqoj8nt9Q5pwtHOQwx5N0y0w_keMVAXUww2PdA8xnvar9e0wxD35QRqg6dLijOGPIRqu_1Cz-iUYp7QzcMdPu5dDHOK44ie5nnxD-_Im96OGU-f3xPy8-Lb9fmP6vLq-_b87LJydSvnyiMy1MUvd77zHXegtOSy6XWnO2x72yN0rdA9uq4k0rJvnfBWCaWgkQrFCfn6pDst3R69w2LDjmZKw77kMdEO5v9NGHbmV7wzsmk01KwIfHoWSPH3gnk2-yE7HEcbMC7ZgGobIYqnFf34Ar2JSwolXqE0MGASVKGqJ8qVL8oJ-4MZYGZt0pQmzdqkWZss_Id_Exzov72JP-cAnBg</recordid><startdate>20150601</startdate><enddate>20150601</enddate><creator>Zengin, Halit</creator><creator>Erbay, Ali Rıza</creator><creator>Okuyucu, Ali</creator><creator>Alaçam, Hasan</creator><creator>Yüksel, Serkan</creator><creator>Meriç, Murat</creator><creator>Soylu, Korhan</creator><creator>Gedikli, Ömer</creator><creator>Murat, Naci</creator><creator>Gülel, Okan</creator><creator>Demircan, Sabri</creator><creator>Akın, Filiz</creator><creator>Yılmaz, Özcan</creator><creator>Şahin, Mahmut</creator><general>Kare Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>EDSIH</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PADUT</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20150601</creationdate><title>The relationship between coronary slow flow phenomenon and urotensin-II: A prospective and controlled study</title><author>Zengin, Halit ; 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In this study, we investigated the role of a very potent vasoconstrictor, urotensin-II (UII), in the pathophysiology of CSF. This prospective and controlled investigation aimed to evaluate the association between CSF and serum levels of UII.
Our study included 32 patients with slow flow in any coronary artery and 32 patients with normal coronary arteries. Coronary flow was calculated using the Thrombolysis in Myocardial Infarction (TIMI) frame count (TFC) method, and CSF was defined as TFC ≥39 for the left anterior descending artery, TFC ≥27 for the circumflex coronary artery, and TFC ≥24 for the right coronary artery. UII levels in blood samples obtained from both groups were measured by enzyme-linked immunosorbent assay (ELISA) method.
UII levels were significantly higher in the CSF group than in the control group [122 pg/mL (71-831), 95 pg/mL (21-635), respectively; p<0.001]. High-density lipoprotein (HDL) levels were lower in the CSF group, and leukocyte counts were significantly higher. A positive correlation between UII and mean TFC (r=0.524, p=0.002) was found in the CSF group. The multivariate logistic regression analysis determined that UII, HDL, and cigarette smoking were independent indicators in predicting CSF (OR=1.010, 95% confidence interval 1.002-1014, p=0.019; OR=0.927, 95% confidence interval 0.869-0.988, p=0.019; OR=5.755, 95% confidence interval 1.272-26.041, p=0.021, respectively).
Serum UII levels were found to be significantly higher in the CSF group, suggesting that UII may be one of the underlying factors in the pathogenesis of CSF.</abstract><cop>Turkey</cop><pub>Kare Publishing</pub><pmid>25430414</pmid><doi>10.5152/akd.2014.5481</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biomarkers - blood Blood Flow Velocity Case-Control Studies Coronary Circulation Coronary Vessels Female Humans Logistic Models Male Middle Aged Myocardial Ischemia - blood Myocardial Ischemia - diagnostic imaging Myocardial Ischemia - physiopathology Original Investigation Prospective Studies Radiography Urotensins - blood |
| title | The relationship between coronary slow flow phenomenon and urotensin-II: A prospective and controlled study |
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