Demonstration of an anti‐hyperalgesic effect of a novel pan‐Trk inhibitor PF‐06273340 in a battery of human evoked pain models

Aim Inhibitors of nerve growth factor (NGF) reduce pain in several chronic pain indications. NGF signals through tyrosine kinase receptors of the tropomyosin‐related kinase (Trk) family and the unrelated p75 receptor. PF‐06273340 is a small molecule inhibitor of Trks A, B and C that reduces pain in...

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Veröffentlicht in:	British journal of clinical pharmacology 2018-02, Vol.84 (2), p.301-309
Hauptverfasser:	Loudon, Peter, Siebenga, Pieter, Gorman, Donal, Gore, Katrina, Dua, Pinky, Amerongen, Guido, Hay, Justin L., Groeneveld, Geert Jan, Butt, Richard P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Analgesics - administration & dosage Analgesics - pharmacokinetics Analgesics - therapeutic use Cross-Over Studies Dose-Response Relationship, Drug Double-Blind Method Healthy Volunteers Humans Hyperalgesia - drug therapy Hyperalgesia - enzymology Male Membrane Glycoproteins - antagonists & inhibitors Middle Aged pain Pain Threshold - drug effects Pharmacodynamics phase I (drug development) Pyrimidines - administration & dosage Pyrimidines - pharmacokinetics Pyrimidines - therapeutic use Pyrroles - administration & dosage Pyrroles - pharmacokinetics Pyrroles - therapeutic use Receptor, trkA - antagonists & inhibitors Receptor, trkB - antagonists & inhibitors Receptor, trkC - antagonists & inhibitors Young Adult
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