A novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO

Bacteria produce chemical signals (pheromones) to coordinate behaviors across a population in a process termed quorum sensing (QS). QS systems comprising peptide pheromones and their corresponding Rgg receptors are widespread among Firmicutes and may be useful targets for manipulating microbial beha...

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Veröffentlicht in:	The Journal of biological chemistry 2018-01, Vol.293 (3), p.931-940
Hauptverfasser:	Pérez Morales, Tiara G., Ratia, Kiira, Wang, Duo-Sheng, Gogos, Artemis, Driver, Tom G., Federle, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	antivirulence Bacterial Proteins - metabolism Endopeptidases - metabolism Gene Expression Regulation, Bacterial gene regulation gram-positive bacteria Gram-Positive Bacteria - metabolism Microbiology neprilysin Neprilysin - metabolism peptidase pheromone Pheromones - metabolism quorum quenching quorum sensing Quorum Sensing - physiology Signal Transduction - genetics Signal Transduction - physiology Streptococcus pyogenes - genetics Streptococcus pyogenes - metabolism
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