Sustained MAPK/ERK Activation in Adult Schwann Cells Impairs Nerve Repair

The MAPK/ERK pathway has a critical role in PNS development. It is required for Schwann cell (SC) differentiation and myelination; sustained embryonic MAPK/ERK activation in SCs enhances myelin growth overcoming signals that normally end myelination. Excess activation of this pathway can be maladapt...

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Veröffentlicht in:	The Journal of neuroscience 2018-01, Vol.38 (3), p.679-690
Hauptverfasser:	Cervellini, Ilaria, Galino, Jorge, Zhu, Ning, Allen, Shannen, Birchmeier, Carmen, Bennett, David L
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation Animals Axons Demyelination Embryos Enzyme Activation - physiology Extracellular signal-regulated kinase Extracellular Signal-Regulated MAP Kinases - metabolism Female Injuries Male MAP kinase Metabolic pathways Mice Mice, Transgenic Mutants Myelin Myelin Sheath Myelination Nerve Crush Nerve Regeneration - physiology Peripheral Nerve Injuries - metabolism Recovery of function Regeneration Reinnervation Repair Schwann cells Schwann Cells - metabolism Sciatic Nerve - injuries Sciatic Nerve - metabolism Skin
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