Phosphorylated CCAAT/Enhancer Binding Protein β Contributes to Rat HIV-Related Neuropathic Pain: In Vitro and In Vivo Studies

Chronic pain is increasingly recognized as an important comorbidity of HIV-infected patients, however, the exact molecular mechanisms of HIV-related pain are still elusive. CCAAT/enhancer binding proteins (C/EBPs) are expressed in various tissues, including the CNS. C/EBPβ, one of the C/EBPs, is inv...

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Veröffentlicht in:	The Journal of neuroscience 2018-01, Vol.38 (3), p.555-574
Hauptverfasser:	Yi, Hyun, Liu, Shue, Kashiwagi, Yuta, Ikegami, Daigo, Huang, Wan, Kanda, Hirotsugu, Iida, Takafumi, Liu, Ching-Hang, Takahashi, Keiya, Lubarsky, David A, Hao, Shuanglin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acquired immune deficiency syndrome AIDS Animals Antisense RNA Biological activity CCAAT-Enhancer-Binding Protein-beta - metabolism CCAAT/enhancer-binding protein Central nervous system Chronic pain Chronic Pain - metabolism Chronic Pain - virology Cyclic AMP response element-binding protein Cyclic AMP Response Element-Binding Protein - metabolism Dorsal horn Glycoprotein gp120 Glycoproteins HIV HIV Envelope Protein gp120 - pharmacology HIV Infections - complications Human immunodeficiency virus In vivo methods and tests Male Mitochondria Molecular modelling Neuralgia Neuralgia - metabolism Neuralgia - virology Pain Pain perception Proteins Rats Rats, Sprague-Dawley Sciatic nerve Signal Transduction - drug effects Signal Transduction - physiology siRNA Spinal cord Spinal Cord Dorsal Horn - drug effects Spinal Cord Dorsal Horn - metabolism Superoxide Superoxides - metabolism Tempol Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-α
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