Mixed signature of activation and dysfunction allows human decidual CD8⁺ T cells to provide both tolerance and immunity

Understanding how decidual CD8⁺ T cell (CD8⁺ dT) cytotoxicity is regulated and how these cells integrate the competing needs for maternal–fetal tolerance and immunity to infection is an important research and clinical goal. Gene-expression analysis of effector-memory CD8⁺ dT demonstrated a mixed tra...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2018-01, Vol.115 (2), p.385-390
Hauptverfasser:	van der Zwan, Anita, Bi, Kevin, Norwitz, Errol R., Crespo, Ângela C., Claas, Frans H. J., Strominger, Jack L., Tilburgs, Tamara
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Biological Sciences CD8 antigen Cell activation Complications CTLA-4 protein Cytotoxicity Decidua Endopeptidase Etiology Fetuses Gene expression Immunity Immunological tolerance Infections Inflammation Lymphocytes Lymphocytes T PD-1 protein Perforin Placenta Pregnancy Pregnancy complications T cell receptors Toxicity Transcription Tumor necrosis factor-α γ-Interferon
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