Hippocampus-dependent memory and allele-specific gene expression in adult offspring of alcohol-consuming dams after neonatal treatment with thyroxin or metformin

Fetal alcohol spectrum disorder (FASD), the result of fetal alcohol exposure (FAE), affects 2–11% of children worldwide, with no effective treatments. Hippocampus-based learning and memory deficits are key symptoms of FASD. Our previous studies show hypothyroxinemia and hyperglycemia of the alcohol-...

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Veröffentlicht in:	Molecular psychiatry 2018-07, Vol.23 (7), p.1643-1651
Hauptverfasser:	Tunc-Ozcan, E, Wert, S L, Lim, P H, Ferreira, A, Redei, E E
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Alcohols Alleles Antidiabetics Behavioral Sciences Biological Psychology Brain Care and treatment Children Cognitive ability Cognitive disorders Dams Diabetes therapy DNA DNA methyltransferase DNMT1 protein Dosage and administration Drinking (Alcoholic beverages) Enzymes Fetal alcohol syndrome Gene expression Genes Genetic research Hippocampus Hormones Hyperglycemia Hypoglycemic agents Imprinting Insulin Insulin-like growth factor II Iodide peroxidase Learning Medical research Medicine Medicine & Public Health Memory Metformin Methyltransferases Neonates Neurodevelopmental disorders Neurosciences Newborn infants Offspring Pharmacotherapy Pregnancy Pregnant women Psychiatry Substance abuse treatment Thyroid Thyroid gland Thyroid hormones Thyroxine Transferases
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