Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global β-Amyloid Burden

IMPORTANCE: The ability to explore associations between reports of subjective cognitive decline (SCD) and biomarkers of early Alzheimer disease (AD) pathophysiologic processes (accumulation of neocortical β-amyloid [Aβ] and tau) provides an important opportunity to understand the basis of SCD and AD...

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Veröffentlicht in:	JAMA neurology 2017-12, Vol.74 (12), p.1455-1463
Hauptverfasser:	Buckley, Rachel F, Hanseeuw, Bernard, Schultz, Aaron P, Vannini, Patrizia, Aghjayan, Sarah L, Properzi, Michael J, Jackson, Jonathan D, Mormino, Elizabeth C, Rentz, Dorene M, Sperling, Reisa A, Johnson, Keith A, Amariglio, Rebecca E
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Amyloid beta-Peptides - metabolism Brain - diagnostic imaging Brain - metabolism Carbolines Cognitive Dysfunction - diagnostic imaging Cognitive Dysfunction - metabolism Cross-Sectional Studies Diagnostic Self Evaluation Entorhinal Cortex - diagnostic imaging Entorhinal Cortex - metabolism Female Frontal Lobe - diagnostic imaging Frontal Lobe - metabolism Humans Male Middle Aged Neocortex - diagnostic imaging Neocortex - metabolism Parietal Lobe - diagnostic imaging Parietal Lobe - metabolism Phenanthrolines Positron-Emission Tomography Radiopharmaceuticals Surveys and Questionnaires tau Proteins - metabolism Tauopathies - diagnostic imaging Tauopathies - metabolism Temporal Lobe - diagnostic imaging Temporal Lobe - metabolism
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