Thermodynamic Coupling Function Analysis of Allosteric Mechanisms in the Human Dopamine Transporter

Allostery plays a crucial role in the mechanism of neurotransmitter-sodium symporters, such as the human dopamine transporter. To investigate the molecular mechanism that couples the transport-associated inward release of the Na+ ion from the Na2 site to intracellular gating, we applied a combinatio...

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Veröffentlicht in:	Biophysical journal 2018-01, Vol.114 (1), p.10-14
Hauptverfasser:	LeVine, Michael V., Cuendet, Michel A., Razavi, Asghar M., Khelashvili, George, Weinstein, Harel
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric properties Allosteric Regulation Animals Biophysical Letter Biophysics Coupling (molecular) Dopamine Dopamine D4 receptors Dopamine Plasma Membrane Transport Proteins - chemistry Dopamine Plasma Membrane Transport Proteins - metabolism Dopamine transporter Function analysis Gating Humans Ions Markov analysis Markov chains Models, Molecular Molecular dynamics Mutation Neurological diseases Protein Conformation Sodium Sodium - metabolism Thermodynamic coupling Thermodynamics Trajectory analysis
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