Generation and Characterization of Alloantigen-Specific Regulatory T Cells For Clinical Transplant Tolerance

Donor-specific CD4 + CD127 − CD25 + FOXP3 + regulatory T cells (AgTregs) have the potential to induce clinical transplant tolerance; however, their expansion ex vivo remains challenging. We optimized a novel expansion protocol to stimulate donor-specific Tregs using soluble 4-trimer CD40 ligand (CD4...

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Veröffentlicht in:	Scientific reports 2018-01, Vol.8 (1), p.1136-14, Article 1136
Hauptverfasser:	Mathew, James M., Voss, Jessica H., McEwen, Scott T., Konieczna, Iwona, Chakraborty, Arjun, Huang, Xuemei, He, Jie, Gallon, Lorenzo, Kornbluth, Richard S., Leventhal, Joseph R.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 13/31 631/250/1854/2812 692/308/575 Antigen-presenting cells Antigen-Presenting Cells - immunology Antigen-Presenting Cells - metabolism Autografts B-Lymphocytes - immunology B-Lymphocytes - metabolism Biomarkers CD25 antigen CD28 antigen CD3 antigen CD4 antigen CD40 antigen CD40L protein Contamination Demethylation Forkhead Transcription Factors - metabolism Foxp3 protein Humanities and Social Sciences Humans Immunological tolerance Immunoregulation Interleukin 2 Isoantigens - immunology Lymphocyte Activation - immunology Lymphocyte Culture Test, Mixed Lymphocytes B Lymphocytes T Methylation multidisciplinary Organ Transplantation Rapamycin Receptors, Antigen, T-Cell Science Science (multidisciplinary) T cell receptors T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - metabolism Transplantation Immunology Transplantation Tolerance - immunology
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