Epigallocatechin gallate (EGCG) reduces the intensity of pancreatic amyloid fibrils in human islet amyloid polypeptide (hIAPP) transgenic mice

The formation of amyloid fibrils by human islet amyloid polypeptide protein (hIAPP) has been implicated in pancreas dysfunction and diabetes. However, efficient treatment options to reduce amyloid fibrils in vivo are still lacking. Therefore, we tested the effect of epigallocatechin gallate (EGCG) o...

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Veröffentlicht in:	Scientific reports 2018-01, Vol.8 (1), p.1116-12, Article 1116
Hauptverfasser:	Franko, Andras, Rodriguez Camargo, Diana C., Böddrich, Annett, Garg, Divita, Rodriguez Camargo, Andres, Rathkolb, Birgit, Janik, Dirk, Aichler, Michaela, Feuchtinger, Annette, Neff, Frauke, Fuchs, Helmut, Wanker, Erich E., Reif, Bernd, Häring, Hans-Ulrich, Peter, Andreas, Hrabě de Angelis, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	119/118 13 13/1 13/51 14/3 140/131 631/45/56 631/57/2269 64/60 692/163/2743/137/1417 692/4017 Amylin Amyloid - chemistry Amyloid - metabolism Amyloidosis - metabolism Amyloidosis - pathology Animals Biomarkers Catechin - analogs & derivatives Catechin - chemistry Catechin - metabolism Catechin - pharmacology Data processing Diabetes Diabetes mellitus Epigallocatechin gallate Fibrillogenesis Humanities and Social Sciences Humans Islet Amyloid Polypeptide - genetics Islet Amyloid Polypeptide - metabolism Mice Mice, Transgenic Models, Molecular Molecular Conformation Molecular structure multidisciplinary Neuroprotective Agents - chemistry Neuroprotective Agents - metabolism Neuroprotective Agents - pharmacology Pancreas Pancreas - metabolism Pancreas - pathology Pancreas - ultrastructure Polypeptides Protein Binding Rodents Science Science (multidisciplinary) Transgenic mice
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