Pharmacologic modeling of primary mitochondrial respiratory chain dysfunction in zebrafish

Mitochondrial respiratory chain (RC) disease is a heterogeneous and highly morbid group of energy deficiency disorders for which no proven effective therapies exist. Robust vertebrate animal models of primary RC dysfunction are needed to explore the effects of variation in RC disease subtypes, tissu...

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Veröffentlicht in:	Neurochemistry international 2018-07, Vol.117, p.23-34
Hauptverfasser:	Byrnes, James, Ganetzky, Rebecca, Lightfoot, Richard, Tzeng, Michael, Nakamaru-Ogiso, Eiko, Seiler, Christoph, Falk, Marni J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chloramphenicol (PubChem CID: 5959) Complex I Complex IV Complex V D. rerio Electron Transport Chain Complex Proteins - antagonists & inhibitors Electron Transport Chain Complex Proteins - metabolism Enzyme Inhibitors - pharmacology Insecticides - pharmacology Mitochondria - drug effects Mitochondria - metabolism Mitochondrial translation Mitotracker green FM (PubChem CID: 59705974) Oligomycin (PubChem CID: 16760598) Probucol (PubChem CID: 4912) Rotenone (PubChem CID: 6758) Rotenone - pharmacology Sodium azide (PubChem CID: 33557) Sodium Azide - pharmacology TMRE (PubChem CID: 2762682) Zebrafish
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