Experimental infection of cattle with Mycobacterium tuberculosis isolates shows the attenuation of the human tubercle bacillus for cattle
The Mycobacterium tuberculosis complex (MTBC) is the collective term given to the group of bacteria that cause tuberculosis (TB) in mammals. It has been reported that M. tuberculosis H37Rv, a standard reference MTBC strain, is attenuated in cattle compared to Mycobacterium bovis . However, as M. tub...
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| Veröffentlicht in: | Scientific reports 2018-01, Vol.8 (1), p.894-13, Article 894 |
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| creator | Villarreal-Ramos, Bernardo Berg, Stefan Whelan, Adam Holbert, Sebastien Carreras, Florence Salguero, Francisco J. Khatri, Bhagwati L. Malone, Kerri Rue-Albrecht, Kevin Shaughnessy, Ronan Smyth, Alicia Ameni, Gobena Aseffa, Abraham Sarradin, Pierre Winter, Nathalie Vordermeier, Martin Gordon, Stephen V. |
| description | The
Mycobacterium tuberculosis
complex (MTBC) is the collective term given to the group of bacteria that cause tuberculosis (TB) in mammals. It has been reported that
M. tuberculosis
H37Rv, a standard reference MTBC strain, is attenuated in cattle compared to
Mycobacterium bovis
. However, as
M. tuberculosis
H37Rv was isolated in the early 1930s, and genetic variants are known to exist, we sought to revisit this question of attenuation of
M. tuberculosis
for cattle by performing a bovine experimental infection with a recent
M. tuberculosis
isolate. Here we report infection of cattle using
M. bovis
AF2122/97,
M. tuberculosis
H37Rv, and
M. tuberculosis
BTB1558, the latter isolated in 2008 during a TB surveillance project in Ethiopian cattle. We show that both
M. tuberculosis
strains caused reduced gross pathology and histopathology in cattle compared to
M. bovis
. Using
M. tuberculosis
H37Rv and
M. bovis
AF2122/97 as the extremes in terms of infection outcome, we used RNA-Seq analysis to explore differences in the peripheral response to infection as a route to identify biomarkers of progressive disease in contrast to a more quiescent, latent infection. Our work shows the attenuation of
M. tuberculosis
strains for cattle, and emphasizes the potential of the bovine model as a ‘One Health’ approach to inform human TB biomarker development and post-exposure vaccine development. |
| doi_str_mv | 10.1038/s41598-017-18575-5 |
| format | Article |
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Mycobacterium tuberculosis
complex (MTBC) is the collective term given to the group of bacteria that cause tuberculosis (TB) in mammals. It has been reported that
M. tuberculosis
H37Rv, a standard reference MTBC strain, is attenuated in cattle compared to
Mycobacterium bovis
. However, as
M. tuberculosis
H37Rv was isolated in the early 1930s, and genetic variants are known to exist, we sought to revisit this question of attenuation of
M. tuberculosis
for cattle by performing a bovine experimental infection with a recent
M. tuberculosis
isolate. Here we report infection of cattle using
M. bovis
AF2122/97,
M. tuberculosis
H37Rv, and
M. tuberculosis
BTB1558, the latter isolated in 2008 during a TB surveillance project in Ethiopian cattle. We show that both
M. tuberculosis
strains caused reduced gross pathology and histopathology in cattle compared to
M. bovis
. Using
M. tuberculosis
H37Rv and
M. bovis
AF2122/97 as the extremes in terms of infection outcome, we used RNA-Seq analysis to explore differences in the peripheral response to infection as a route to identify biomarkers of progressive disease in contrast to a more quiescent, latent infection. Our work shows the attenuation of
M. tuberculosis
strains for cattle, and emphasizes the potential of the bovine model as a ‘One Health’ approach to inform human TB biomarker development and post-exposure vaccine development.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-017-18575-5</identifier><identifier>PMID: 29343690</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13/21 ; 38/39 ; 38/91 ; 631/326/1320 ; 631/326/2521 ; 631/326/421 ; Animal biology ; Animals ; Bacillus - immunology ; Biomarkers - metabolism ; Bovidae ; Cattle ; Experimental infection ; Female ; Genetic diversity ; Genetic variance ; Histopathology ; Humanities and Social Sciences ; Humans ; Infections ; Latent infection ; Life Sciences ; Microbiology and Parasitology ; multidisciplinary ; Mycobacterium bovis - immunology ; Mycobacterium tuberculosis ; Mycobacterium tuberculosis - immunology ; Ribonucleic acid ; RNA ; Science ; Science (multidisciplinary) ; Strains (organisms) ; Tuberculosis ; Tuberculosis - immunology ; Tuberculosis - metabolism ; Tuberculosis - microbiology ; Tuberculosis, Bovine - immunology ; Tuberculosis, Bovine - metabolism ; Tuberculosis, Bovine - microbiology ; Vaccine development ; Veterinary medicine and animal Health</subject><ispartof>Scientific reports, 2018-01, Vol.8 (1), p.894-13, Article 894</ispartof><rights>The Author(s) 2018</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Attribution</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c615t-7344e7cb5239798067c29ca2be87eb593c0c574caa6a335a48bb4a1186fc4b013</citedby><cites>FETCH-LOGICAL-c615t-7344e7cb5239798067c29ca2be87eb593c0c574caa6a335a48bb4a1186fc4b013</cites><orcidid>0000-0002-8028-1150 ; 0000-0003-3899-3872 ; 0000-0001-7655-3144 ; 0000-0002-4833-5542 ; 0000-0003-0994-7834</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772528/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5772528/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27923,27924,41119,42188,51575,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29343690$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.inrae.fr/hal-02624695$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Villarreal-Ramos, Bernardo</creatorcontrib><creatorcontrib>Berg, Stefan</creatorcontrib><creatorcontrib>Whelan, Adam</creatorcontrib><creatorcontrib>Holbert, Sebastien</creatorcontrib><creatorcontrib>Carreras, Florence</creatorcontrib><creatorcontrib>Salguero, Francisco J.</creatorcontrib><creatorcontrib>Khatri, Bhagwati L.</creatorcontrib><creatorcontrib>Malone, Kerri</creatorcontrib><creatorcontrib>Rue-Albrecht, Kevin</creatorcontrib><creatorcontrib>Shaughnessy, Ronan</creatorcontrib><creatorcontrib>Smyth, Alicia</creatorcontrib><creatorcontrib>Ameni, Gobena</creatorcontrib><creatorcontrib>Aseffa, Abraham</creatorcontrib><creatorcontrib>Sarradin, Pierre</creatorcontrib><creatorcontrib>Winter, Nathalie</creatorcontrib><creatorcontrib>Vordermeier, Martin</creatorcontrib><creatorcontrib>Gordon, Stephen V.</creatorcontrib><title>Experimental infection of cattle with Mycobacterium tuberculosis isolates shows the attenuation of the human tubercle bacillus for cattle</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>The
Mycobacterium tuberculosis
complex (MTBC) is the collective term given to the group of bacteria that cause tuberculosis (TB) in mammals. It has been reported that
M. tuberculosis
H37Rv, a standard reference MTBC strain, is attenuated in cattle compared to
Mycobacterium bovis
. However, as
M. tuberculosis
H37Rv was isolated in the early 1930s, and genetic variants are known to exist, we sought to revisit this question of attenuation of
M. tuberculosis
for cattle by performing a bovine experimental infection with a recent
M. tuberculosis
isolate. Here we report infection of cattle using
M. bovis
AF2122/97,
M. tuberculosis
H37Rv, and
M. tuberculosis
BTB1558, the latter isolated in 2008 during a TB surveillance project in Ethiopian cattle. We show that both
M. tuberculosis
strains caused reduced gross pathology and histopathology in cattle compared to
M. bovis
. Using
M. tuberculosis
H37Rv and
M. bovis
AF2122/97 as the extremes in terms of infection outcome, we used RNA-Seq analysis to explore differences in the peripheral response to infection as a route to identify biomarkers of progressive disease in contrast to a more quiescent, latent infection. Our work shows the attenuation of
M. tuberculosis
strains for cattle, and emphasizes the potential of the bovine model as a ‘One Health’ approach to inform human TB biomarker development and post-exposure vaccine development.</description><subject>13/21</subject><subject>38/39</subject><subject>38/91</subject><subject>631/326/1320</subject><subject>631/326/2521</subject><subject>631/326/421</subject><subject>Animal biology</subject><subject>Animals</subject><subject>Bacillus - immunology</subject><subject>Biomarkers - metabolism</subject><subject>Bovidae</subject><subject>Cattle</subject><subject>Experimental infection</subject><subject>Female</subject><subject>Genetic diversity</subject><subject>Genetic variance</subject><subject>Histopathology</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Infections</subject><subject>Latent infection</subject><subject>Life Sciences</subject><subject>Microbiology and Parasitology</subject><subject>multidisciplinary</subject><subject>Mycobacterium bovis - immunology</subject><subject>Mycobacterium tuberculosis</subject><subject>Mycobacterium tuberculosis - immunology</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Strains (organisms)</subject><subject>Tuberculosis</subject><subject>Tuberculosis - immunology</subject><subject>Tuberculosis - metabolism</subject><subject>Tuberculosis - microbiology</subject><subject>Tuberculosis, Bovine - immunology</subject><subject>Tuberculosis, Bovine - metabolism</subject><subject>Tuberculosis, Bovine - microbiology</subject><subject>Vaccine development</subject><subject>Veterinary medicine and animal Health</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1UktrFTEUHkSxpfYPuJCAG12M5jlJNkIp1QpX3LTrkImZTkpmcs2jtT-h_7oZ57ZcC2aTcM73yDl8TfMWwU8IEvE5UcSkaCHiLRKMs5a9aA4xpKzFBOOXe--D5jila1gPw5Ii-bo5wJJQ0kl42Nyf_dna6CY7Z-2BmwdrsgszCAMwOmdvwa3LI_hxZ0KvTa7QMoFcehtN8SG5BFwKXmebQBrDbQJ5tKAS7Vz0o9BSGsuk5x2xilYt531JYAhxZ_SmeTVon-zx7j5qLr-eXZyet5uf376fnmxa0yGWW04otdz0DBPJpYAdN1gajXsruO2ZJAYaxqnRutOEME1F31ONkOgGQ3uIyFHzZdXdln6yv0ydPGqvtnUJOt6poJ36tzO7UV2FG8U4xwyLKvBxFRif0c5PNmqpQdxh2kl2s5h92JnF8LvYlNXkkrHe69mGkhSSQnYQwW6Bvn8GvQ4lznUVC0owhDlfUHhFmRhSinZ4-gGCagmGWoOhajDU32AoVknv9kd-ojzGoALICki1NV_ZuOf9f9kHEj_Gcg</recordid><startdate>20180117</startdate><enddate>20180117</enddate><creator>Villarreal-Ramos, Bernardo</creator><creator>Berg, Stefan</creator><creator>Whelan, Adam</creator><creator>Holbert, Sebastien</creator><creator>Carreras, Florence</creator><creator>Salguero, Francisco J.</creator><creator>Khatri, Bhagwati L.</creator><creator>Malone, Kerri</creator><creator>Rue-Albrecht, Kevin</creator><creator>Shaughnessy, Ronan</creator><creator>Smyth, Alicia</creator><creator>Ameni, Gobena</creator><creator>Aseffa, Abraham</creator><creator>Sarradin, Pierre</creator><creator>Winter, Nathalie</creator><creator>Vordermeier, Martin</creator><creator>Gordon, Stephen V.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8028-1150</orcidid><orcidid>https://orcid.org/0000-0003-3899-3872</orcidid><orcidid>https://orcid.org/0000-0001-7655-3144</orcidid><orcidid>https://orcid.org/0000-0002-4833-5542</orcidid><orcidid>https://orcid.org/0000-0003-0994-7834</orcidid></search><sort><creationdate>20180117</creationdate><title>Experimental infection of cattle with Mycobacterium tuberculosis isolates shows the attenuation of the human tubercle bacillus for cattle</title><author>Villarreal-Ramos, Bernardo ; Berg, Stefan ; Whelan, Adam ; Holbert, Sebastien ; Carreras, Florence ; Salguero, Francisco J. ; Khatri, Bhagwati L. ; Malone, Kerri ; Rue-Albrecht, Kevin ; Shaughnessy, Ronan ; Smyth, Alicia ; Ameni, Gobena ; Aseffa, Abraham ; Sarradin, Pierre ; Winter, Nathalie ; Vordermeier, Martin ; Gordon, Stephen V.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c615t-7344e7cb5239798067c29ca2be87eb593c0c574caa6a335a48bb4a1186fc4b013</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>13/21</topic><topic>38/39</topic><topic>38/91</topic><topic>631/326/1320</topic><topic>631/326/2521</topic><topic>631/326/421</topic><topic>Animal biology</topic><topic>Animals</topic><topic>Bacillus - 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Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Villarreal-Ramos, Bernardo</au><au>Berg, Stefan</au><au>Whelan, Adam</au><au>Holbert, Sebastien</au><au>Carreras, Florence</au><au>Salguero, Francisco J.</au><au>Khatri, Bhagwati L.</au><au>Malone, Kerri</au><au>Rue-Albrecht, Kevin</au><au>Shaughnessy, Ronan</au><au>Smyth, Alicia</au><au>Ameni, Gobena</au><au>Aseffa, Abraham</au><au>Sarradin, Pierre</au><au>Winter, Nathalie</au><au>Vordermeier, Martin</au><au>Gordon, Stephen V.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental infection of cattle with Mycobacterium tuberculosis isolates shows the attenuation of the human tubercle bacillus for cattle</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2018-01-17</date><risdate>2018</risdate><volume>8</volume><issue>1</issue><spage>894</spage><epage>13</epage><pages>894-13</pages><artnum>894</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>The
Mycobacterium tuberculosis
complex (MTBC) is the collective term given to the group of bacteria that cause tuberculosis (TB) in mammals. It has been reported that
M. tuberculosis
H37Rv, a standard reference MTBC strain, is attenuated in cattle compared to
Mycobacterium bovis
. However, as
M. tuberculosis
H37Rv was isolated in the early 1930s, and genetic variants are known to exist, we sought to revisit this question of attenuation of
M. tuberculosis
for cattle by performing a bovine experimental infection with a recent
M. tuberculosis
isolate. Here we report infection of cattle using
M. bovis
AF2122/97,
M. tuberculosis
H37Rv, and
M. tuberculosis
BTB1558, the latter isolated in 2008 during a TB surveillance project in Ethiopian cattle. We show that both
M. tuberculosis
strains caused reduced gross pathology and histopathology in cattle compared to
M. bovis
. Using
M. tuberculosis
H37Rv and
M. bovis
AF2122/97 as the extremes in terms of infection outcome, we used RNA-Seq analysis to explore differences in the peripheral response to infection as a route to identify biomarkers of progressive disease in contrast to a more quiescent, latent infection. Our work shows the attenuation of
M. tuberculosis
strains for cattle, and emphasizes the potential of the bovine model as a ‘One Health’ approach to inform human TB biomarker development and post-exposure vaccine development.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29343690</pmid><doi>10.1038/s41598-017-18575-5</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-8028-1150</orcidid><orcidid>https://orcid.org/0000-0003-3899-3872</orcidid><orcidid>https://orcid.org/0000-0001-7655-3144</orcidid><orcidid>https://orcid.org/0000-0002-4833-5542</orcidid><orcidid>https://orcid.org/0000-0003-0994-7834</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2018-01, Vol.8 (1), p.894-13, Article 894 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5772528 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Springer Nature OA Free Journals; Nature Free; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | 13/21 38/39 38/91 631/326/1320 631/326/2521 631/326/421 Animal biology Animals Bacillus - immunology Biomarkers - metabolism Bovidae Cattle Experimental infection Female Genetic diversity Genetic variance Histopathology Humanities and Social Sciences Humans Infections Latent infection Life Sciences Microbiology and Parasitology multidisciplinary Mycobacterium bovis - immunology Mycobacterium tuberculosis Mycobacterium tuberculosis - immunology Ribonucleic acid RNA Science Science (multidisciplinary) Strains (organisms) Tuberculosis Tuberculosis - immunology Tuberculosis - metabolism Tuberculosis - microbiology Tuberculosis, Bovine - immunology Tuberculosis, Bovine - metabolism Tuberculosis, Bovine - microbiology Vaccine development Veterinary medicine and animal Health |
| title | Experimental infection of cattle with Mycobacterium tuberculosis isolates shows the attenuation of the human tubercle bacillus for cattle |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-12T11%3A26%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Experimental%20infection%20of%20cattle%20with%20Mycobacterium%20tuberculosis%20isolates%20shows%20the%20attenuation%20of%20the%20human%20tubercle%20bacillus%20for%20cattle&rft.jtitle=Scientific%20reports&rft.au=Villarreal-Ramos,%20Bernardo&rft.date=2018-01-17&rft.volume=8&rft.issue=1&rft.spage=894&rft.epage=13&rft.pages=894-13&rft.artnum=894&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/s41598-017-18575-5&rft_dat=%3Cproquest_pubme%3E1989601061%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1988512771&rft_id=info:pmid/29343690&rfr_iscdi=true |