Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potential
Diabetic kidney disease, a leading cause of end-stage renal disease, has become a serious public health problem worldwide and lacks effective therapies. Autophagy is a highly conserved lysosomal degradation pathway that removes protein aggregates and damaged organelles to maintain cellular homeostas...
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| Veröffentlicht in: | Cellular and molecular life sciences : CMLS 2018-02, Vol.75 (4), p.669-688 |
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| creator | Yang, Danyi Livingston, Man J. Liu, Zhiwen Dong, Guie Zhang, Ming Chen, Jian-Kang Dong, Zheng |
| description | Diabetic kidney disease, a leading cause of end-stage renal disease, has become a serious public health problem worldwide and lacks effective therapies. Autophagy is a highly conserved lysosomal degradation pathway that removes protein aggregates and damaged organelles to maintain cellular homeostasis. As important stress-responsive machinery, autophagy is involved in the pathogenesis of various diseases. Emerging evidence has suggested that dysregulated autophagy may contribute to both glomerular and tubulointerstitial pathologies in kidneys under diabetic conditions. This review summarizes the recent findings regarding the role of autophagy in the pathogenesis of diabetic kidney disease and highlights the regulation of autophagy by the nutrient-sensing pathways and intracellular stress signaling in this disease. The advances in our understanding of autophagy in diabetic kidney disease will facilitate the discovery of a new therapeutic target for the prevention and treatment of this life-threatening diabetes complication. |
| doi_str_mv | 10.1007/s00018-017-2639-1 |
| format | Article |
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Autophagy is a highly conserved lysosomal degradation pathway that removes protein aggregates and damaged organelles to maintain cellular homeostasis. As important stress-responsive machinery, autophagy is involved in the pathogenesis of various diseases. Emerging evidence has suggested that dysregulated autophagy may contribute to both glomerular and tubulointerstitial pathologies in kidneys under diabetic conditions. This review summarizes the recent findings regarding the role of autophagy in the pathogenesis of diabetic kidney disease and highlights the regulation of autophagy by the nutrient-sensing pathways and intracellular stress signaling in this disease. The advances in our understanding of autophagy in diabetic kidney disease will facilitate the discovery of a new therapeutic target for the prevention and treatment of this life-threatening diabetes complication.</description><identifier>ISSN: 1420-682X</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-017-2639-1</identifier><identifier>PMID: 28871310</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Animals ; Autophagy ; Autophagy - physiology ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Diabetes ; Diabetes mellitus ; Diabetic Nephropathies - metabolism ; Diabetic Nephropathies - pathology ; Diabetic Nephropathies - physiopathology ; Diabetic Nephropathies - therapy ; Diabetic nephropathy ; End-stage renal disease ; Homeostasis ; Homeostasis - physiology ; Humans ; Intracellular signalling ; Kidney - metabolism ; Kidney - physiology ; Kidney diseases ; Kidneys ; Life Sciences ; Lysosomes ; Machinery and equipment ; Organelles ; Pathogenesis ; Phagocytosis ; Podocytes - metabolism ; Podocytes - physiology ; Public health ; Review ; Signal Transduction - physiology ; Therapies, Investigational - methods ; Therapies, Investigational - trends</subject><ispartof>Cellular and molecular life sciences : CMLS, 2018-02, Vol.75 (4), p.669-688</ispartof><rights>Springer International Publishing AG 2017</rights><rights>Cellular and Molecular Life Sciences is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c536t-7da36e9d846163fd900f1a9bb0ffb1e2117291bf938e9910d67e8e40248230733</citedby><cites>FETCH-LOGICAL-c536t-7da36e9d846163fd900f1a9bb0ffb1e2117291bf938e9910d67e8e40248230733</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771948/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771948/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,729,782,786,887,27931,27932,41495,42564,51326,53798,53800</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28871310$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Danyi</creatorcontrib><creatorcontrib>Livingston, Man J.</creatorcontrib><creatorcontrib>Liu, Zhiwen</creatorcontrib><creatorcontrib>Dong, Guie</creatorcontrib><creatorcontrib>Zhang, Ming</creatorcontrib><creatorcontrib>Chen, Jian-Kang</creatorcontrib><creatorcontrib>Dong, Zheng</creatorcontrib><title>Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potential</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>Diabetic kidney disease, a leading cause of end-stage renal disease, has become a serious public health problem worldwide and lacks effective therapies. Autophagy is a highly conserved lysosomal degradation pathway that removes protein aggregates and damaged organelles to maintain cellular homeostasis. As important stress-responsive machinery, autophagy is involved in the pathogenesis of various diseases. Emerging evidence has suggested that dysregulated autophagy may contribute to both glomerular and tubulointerstitial pathologies in kidneys under diabetic conditions. This review summarizes the recent findings regarding the role of autophagy in the pathogenesis of diabetic kidney disease and highlights the regulation of autophagy by the nutrient-sensing pathways and intracellular stress signaling in this disease. The advances in our understanding of autophagy in diabetic kidney disease will facilitate the discovery of a new therapeutic target for the prevention and treatment of this life-threatening diabetes complication.</description><subject>Animals</subject><subject>Autophagy</subject><subject>Autophagy - physiology</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetic Nephropathies - metabolism</subject><subject>Diabetic Nephropathies - pathology</subject><subject>Diabetic Nephropathies - physiopathology</subject><subject>Diabetic Nephropathies - therapy</subject><subject>Diabetic nephropathy</subject><subject>End-stage renal disease</subject><subject>Homeostasis</subject><subject>Homeostasis - physiology</subject><subject>Humans</subject><subject>Intracellular signalling</subject><subject>Kidney - metabolism</subject><subject>Kidney - physiology</subject><subject>Kidney diseases</subject><subject>Kidneys</subject><subject>Life Sciences</subject><subject>Lysosomes</subject><subject>Machinery and equipment</subject><subject>Organelles</subject><subject>Pathogenesis</subject><subject>Phagocytosis</subject><subject>Podocytes - metabolism</subject><subject>Podocytes - physiology</subject><subject>Public health</subject><subject>Review</subject><subject>Signal Transduction - physiology</subject><subject>Therapies, Investigational - methods</subject><subject>Therapies, Investigational - trends</subject><issn>1420-682X</issn><issn>1420-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kU1r3DAQhkVpaJJtf0AvxdBLD3Gjkbz66KEQQr8gkEsLvRQh22OvUq3lSnJh_3217DakhZw0Yp73nRleQl4CfQuUystEKQVVU5A1E1zX8IScQcNoramEp8daKPb9lJyndFfgtWLiGTllSkngQM_Ij6slh3ljx13lpqp3tsXsuuqn6yfclX9Cm_BdFXFcvM0uTBfVbPMm-DC6zvoqBo-VnfoqbzDaGZe9eg4Zp-ysf05OBusTvji-K_Lt44ev15_rm9tPX66vbupuzUWuZW-5QN2rRoDgQ68pHcDqtqXD0AIyAMk0tIPmCrUG2guJChvKGsU4lZyvyPuD77y0W-y7Mj1ab-botjbuTLDO_NuZ3MaM4bdZSwm6UcXgzdEghl8Lpmy2LnXovZ0wLMmA5msFTJb1VuT1f-hdWOJUziuUZlILwVih4EB1MaQUcbhfBqjZh2cO4ZkSntmHZ6BoXj284l7xN60CsAOQSmsaMT4Y_ajrH4_4paI</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Yang, Danyi</creator><creator>Livingston, Man J.</creator><creator>Liu, Zhiwen</creator><creator>Dong, Guie</creator><creator>Zhang, Ming</creator><creator>Chen, Jian-Kang</creator><creator>Dong, Zheng</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180201</creationdate><title>Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potential</title><author>Yang, Danyi ; Livingston, Man J. ; Liu, Zhiwen ; Dong, Guie ; Zhang, Ming ; Chen, Jian-Kang ; Dong, Zheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c536t-7da36e9d846163fd900f1a9bb0ffb1e2117291bf938e9910d67e8e40248230733</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Autophagy</topic><topic>Autophagy - physiology</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetic Nephropathies - metabolism</topic><topic>Diabetic Nephropathies - pathology</topic><topic>Diabetic Nephropathies - physiopathology</topic><topic>Diabetic Nephropathies - therapy</topic><topic>Diabetic nephropathy</topic><topic>End-stage renal disease</topic><topic>Homeostasis</topic><topic>Homeostasis - physiology</topic><topic>Humans</topic><topic>Intracellular signalling</topic><topic>Kidney - metabolism</topic><topic>Kidney - physiology</topic><topic>Kidney diseases</topic><topic>Kidneys</topic><topic>Life Sciences</topic><topic>Lysosomes</topic><topic>Machinery and equipment</topic><topic>Organelles</topic><topic>Pathogenesis</topic><topic>Phagocytosis</topic><topic>Podocytes - metabolism</topic><topic>Podocytes - physiology</topic><topic>Public health</topic><topic>Review</topic><topic>Signal Transduction - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cellular and molecular life sciences : CMLS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Danyi</au><au>Livingston, Man J.</au><au>Liu, Zhiwen</au><au>Dong, Guie</au><au>Zhang, Ming</au><au>Chen, Jian-Kang</au><au>Dong, Zheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potential</atitle><jtitle>Cellular and molecular life sciences : CMLS</jtitle><stitle>Cell. Mol. Life Sci</stitle><addtitle>Cell Mol Life Sci</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>75</volume><issue>4</issue><spage>669</spage><epage>688</epage><pages>669-688</pages><issn>1420-682X</issn><eissn>1420-9071</eissn><abstract>Diabetic kidney disease, a leading cause of end-stage renal disease, has become a serious public health problem worldwide and lacks effective therapies. Autophagy is a highly conserved lysosomal degradation pathway that removes protein aggregates and damaged organelles to maintain cellular homeostasis. As important stress-responsive machinery, autophagy is involved in the pathogenesis of various diseases. Emerging evidence has suggested that dysregulated autophagy may contribute to both glomerular and tubulointerstitial pathologies in kidneys under diabetic conditions. This review summarizes the recent findings regarding the role of autophagy in the pathogenesis of diabetic kidney disease and highlights the regulation of autophagy by the nutrient-sensing pathways and intracellular stress signaling in this disease. The advances in our understanding of autophagy in diabetic kidney disease will facilitate the discovery of a new therapeutic target for the prevention and treatment of this life-threatening diabetes complication.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>28871310</pmid><doi>10.1007/s00018-017-2639-1</doi><tpages>20</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Autophagy Autophagy - physiology Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Diabetes Diabetes mellitus Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology Diabetic Nephropathies - physiopathology Diabetic Nephropathies - therapy Diabetic nephropathy End-stage renal disease Homeostasis Homeostasis - physiology Humans Intracellular signalling Kidney - metabolism Kidney - physiology Kidney diseases Kidneys Life Sciences Lysosomes Machinery and equipment Organelles Pathogenesis Phagocytosis Podocytes - metabolism Podocytes - physiology Public health Review Signal Transduction - physiology Therapies, Investigational - methods Therapies, Investigational - trends |
| title | Autophagy in diabetic kidney disease: regulation, pathological role and therapeutic potential |
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