Loss of PRP4K drives anoikis resistance in part by dysregulation of epidermal growth factor receptor endosomal trafficking

Anoikis acts as a critical barrier to metastasis by inducing cell death upon cancer cell detachment from the extracellular matrix (ECM), thereby preventing tumor cell dissemination to secondary sites. The induction of anoikis requires the lysosomal-mediated downregulation of epidermal growth factor...

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Veröffentlicht in:	Oncogene 2018-01, Vol.37 (2), p.174-184
Hauptverfasser:	Corkery, D P, Clarke, L E, Gebremeskel, S, Salsman, J, Pinder, J, Le Page, C, Meunier, L, Xu, Z, Mes-Masson, A-M, Berman, J N, Johnston, B, Dellaire, G
Format:	Artikel
Sprache:	eng
Schlagworte:	13/95 14/19 42/41 631/67/1517/1709 631/80/82/23 631/80/86/2368 692/53 82/51 96/106 Animals Anoikis Anoikis - genetics Apoptosis Biomarkers, Tumor - deficiency Biomarkers, Tumor - genetics Breast cancer Breast Neoplasms - pathology Cancer cells Cell Biology Cell death Cell Line, Tumor Cell Nucleus - metabolism Down-Regulation Endosomes - metabolism Epidermal growth factor Epidermal Growth Factor - metabolism Epidermal growth factor receptors Epithelial Cells - cytology Epithelial Cells - pathology Extracellular matrix Female Growth factor receptors Homeostasis Human Genetics Humans Internal Medicine Localization Lung cancer Lung Neoplasms - pathology Medicine Medicine & Public Health Metastases Metastasis Mice Mice, Inbred C57BL mRNA Neoplasm Invasiveness - pathology Oncology Original original-article Ovarian cancer Ovarian Neoplasms - pathology Protein transport Protein-Serine-Threonine Kinases - deficiency Protein-Serine-Threonine Kinases - genetics Receptor, Epidermal Growth Factor - metabolism Ribonucleoprotein, U4-U6 Small Nuclear - deficiency Ribonucleoprotein, U4-U6 Small Nuclear - genetics RNA, Small Interfering - metabolism Signal Transduction - genetics Splicing factors TrkB receptors Vimentin Xenograft Model Antitumor Assays Xenografts Zebrafish
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