Bacteriophages targeting intestinal epithelial cells: a potential novel form of immunotherapy
In addition to their established role as a physical barrier to invading pathogens and other harmful agents, intestinal epithelial cells (IEC) are actively involved in local immune reactions. In the past years, evidence has accumulated suggesting the role of IEC in the immunopathology of intestinal i...
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| Veröffentlicht in: | Cellular and molecular life sciences : CMLS 2018-02, Vol.75 (4), p.589-595 |
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| creator | Górski, Andrzej Jończyk-Matysiak, Ewa Łusiak-Szelachowska, Marzanna Międzybrodzki, Ryszard Weber-Dąbrowska, Beata Borysowski, Jan |
| description | In addition to their established role as a physical barrier to invading pathogens and other harmful agents, intestinal epithelial cells (IEC) are actively involved in local immune reactions. In the past years, evidence has accumulated suggesting the role of IEC in the immunopathology of intestinal inflammatory disorders (IBD). Recent advances in research on bacteriophages strongly suggest that—in addition to their established antibacterial activity—they have immunomodulating properties that are potentially useful in the clinic. We suggest that these immunomodulating phage activities targeting IEC may open novel treatment perspectives in disorders of the alimentary tract, particularly IBD. |
| doi_str_mv | 10.1007/s00018-017-2715-6 |
| format | Article |
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In the past years, evidence has accumulated suggesting the role of IEC in the immunopathology of intestinal inflammatory disorders (IBD). Recent advances in research on bacteriophages strongly suggest that—in addition to their established antibacterial activity—they have immunomodulating properties that are potentially useful in the clinic. We suggest that these immunomodulating phage activities targeting IEC may open novel treatment perspectives in disorders of the alimentary tract, particularly IBD.</description><identifier>ISSN: 1420-682X</identifier><identifier>ISSN: 1420-9071</identifier><identifier>EISSN: 1420-9071</identifier><identifier>DOI: 10.1007/s00018-017-2715-6</identifier><identifier>PMID: 29164271</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Animals ; Antibacterial activity ; bacteriophages ; Bacteriophages - physiology ; Barriers ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Cell Biology ; Disorders ; Epithelial cells ; Epithelial Cells - immunology ; Epithelial Cells - pathology ; Gastrointestinal tract ; Humans ; immune response ; Immunomodulation - physiology ; immunomodulators ; immunopathology ; Immunotherapy ; Immunotherapy - methods ; Inflammatory Bowel Diseases - pathology ; Inflammatory Bowel Diseases - therapy ; Inflammatory diseases ; intestinal mucosa ; Intestinal Mucosa - immunology ; Intestinal Mucosa - pathology ; Intestine ; Intestines - immunology ; Intestines - pathology ; Life Sciences ; pathogens ; Phages ; Visions and Reflections</subject><ispartof>Cellular and molecular life sciences : CMLS, 2018-02, Vol.75 (4), p.589-595</ispartof><rights>The Author(s) 2017</rights><rights>Cellular and Molecular Life Sciences is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c503t-872185b99ad31541188cb74a73634e4dde623018045210de97164178509b3cec3</citedby><cites>FETCH-LOGICAL-c503t-872185b99ad31541188cb74a73634e4dde623018045210de97164178509b3cec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769817/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5769817/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,41464,42533,51294,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29164271$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Górski, Andrzej</creatorcontrib><creatorcontrib>Jończyk-Matysiak, Ewa</creatorcontrib><creatorcontrib>Łusiak-Szelachowska, Marzanna</creatorcontrib><creatorcontrib>Międzybrodzki, Ryszard</creatorcontrib><creatorcontrib>Weber-Dąbrowska, Beata</creatorcontrib><creatorcontrib>Borysowski, Jan</creatorcontrib><title>Bacteriophages targeting intestinal epithelial cells: a potential novel form of immunotherapy</title><title>Cellular and molecular life sciences : CMLS</title><addtitle>Cell. Mol. Life Sci</addtitle><addtitle>Cell Mol Life Sci</addtitle><description>In addition to their established role as a physical barrier to invading pathogens and other harmful agents, intestinal epithelial cells (IEC) are actively involved in local immune reactions. In the past years, evidence has accumulated suggesting the role of IEC in the immunopathology of intestinal inflammatory disorders (IBD). Recent advances in research on bacteriophages strongly suggest that—in addition to their established antibacterial activity—they have immunomodulating properties that are potentially useful in the clinic. We suggest that these immunomodulating phage activities targeting IEC may open novel treatment perspectives in disorders of the alimentary tract, particularly IBD.</description><subject>Animals</subject><subject>Antibacterial activity</subject><subject>bacteriophages</subject><subject>Bacteriophages - physiology</subject><subject>Barriers</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell Biology</subject><subject>Disorders</subject><subject>Epithelial cells</subject><subject>Epithelial Cells - immunology</subject><subject>Epithelial Cells - pathology</subject><subject>Gastrointestinal tract</subject><subject>Humans</subject><subject>immune response</subject><subject>Immunomodulation - physiology</subject><subject>immunomodulators</subject><subject>immunopathology</subject><subject>Immunotherapy</subject><subject>Immunotherapy - methods</subject><subject>Inflammatory Bowel Diseases - pathology</subject><subject>Inflammatory Bowel Diseases - therapy</subject><subject>Inflammatory diseases</subject><subject>intestinal mucosa</subject><subject>Intestinal Mucosa - immunology</subject><subject>Intestinal Mucosa - pathology</subject><subject>Intestine</subject><subject>Intestines - immunology</subject><subject>Intestines - pathology</subject><subject>Life Sciences</subject><subject>pathogens</subject><subject>Phages</subject><subject>Visions and 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targeting intestinal epithelial cells: a potential novel form of immunotherapy</title><author>Górski, Andrzej ; Jończyk-Matysiak, Ewa ; Łusiak-Szelachowska, Marzanna ; Międzybrodzki, Ryszard ; Weber-Dąbrowska, Beata ; Borysowski, Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c503t-872185b99ad31541188cb74a73634e4dde623018045210de97164178509b3cec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Antibacterial activity</topic><topic>bacteriophages</topic><topic>Bacteriophages - physiology</topic><topic>Barriers</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Cell Biology</topic><topic>Disorders</topic><topic>Epithelial cells</topic><topic>Epithelial Cells - immunology</topic><topic>Epithelial Cells - pathology</topic><topic>Gastrointestinal 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Mol. Life Sci</stitle><addtitle>Cell Mol Life Sci</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>75</volume><issue>4</issue><spage>589</spage><epage>595</epage><pages>589-595</pages><issn>1420-682X</issn><issn>1420-9071</issn><eissn>1420-9071</eissn><abstract>In addition to their established role as a physical barrier to invading pathogens and other harmful agents, intestinal epithelial cells (IEC) are actively involved in local immune reactions. In the past years, evidence has accumulated suggesting the role of IEC in the immunopathology of intestinal inflammatory disorders (IBD). Recent advances in research on bacteriophages strongly suggest that—in addition to their established antibacterial activity—they have immunomodulating properties that are potentially useful in the clinic. We suggest that these immunomodulating phage activities targeting IEC may open novel treatment perspectives in disorders of the alimentary tract, particularly IBD.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>29164271</pmid><doi>10.1007/s00018-017-2715-6</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antibacterial activity bacteriophages Bacteriophages - physiology Barriers Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Disorders Epithelial cells Epithelial Cells - immunology Epithelial Cells - pathology Gastrointestinal tract Humans immune response Immunomodulation - physiology immunomodulators immunopathology Immunotherapy Immunotherapy - methods Inflammatory Bowel Diseases - pathology Inflammatory Bowel Diseases - therapy Inflammatory diseases intestinal mucosa Intestinal Mucosa - immunology Intestinal Mucosa - pathology Intestine Intestines - immunology Intestines - pathology Life Sciences pathogens Phages Visions and Reflections |
| title | Bacteriophages targeting intestinal epithelial cells: a potential novel form of immunotherapy |
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