Microfluidic chest cavities reveal that transmural pressure controls the rate of lung development

Mechanical forces are increasingly recognized to regulate morphogenesis, but how this is accomplished in the context of the multiple tissue types present within a developing organ remains unclear. Here, we use bioengineered 'microfluidic chest cavities' to precisely control the mechanical...

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Veröffentlicht in:Development (Cambridge) 2017-12, Vol.144 (23), p.4328-4335
Hauptverfasser: Nelson, Celeste M, Gleghorn, Jason P, Pang, Mei-Fong, Jaslove, Jacob M, Goodwin, Katharine, Varner, Victor D, Miller, Erin, Radisky, Derek C, Stone, Howard A
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Sprache:eng
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