ICG-001 Exerts Potent Anticancer Activity Against Uveal Melanoma Cells

Uveal melanoma (UM) is uniformly refractory to all available systemic chemotherapies, thus creating an urgent need for novel therapeutics. In this study, we investigated the sensitivity of UM cells to ICG-001, a small molecule reported to suppress the Wnt/β-catenin-mediated transcriptional program....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Investigative ophthalmology & visual science 2018-01, Vol.59 (1), p.132-143
Hauptverfasser:	Kaochar, Salma, Dong, Jianrong, Torres, Marie, Rajapakshe, Kimal, Nikolos, Fotis, Davis, Christel M, Ehli, Erik A, Coarfa, Cristian, Mitsiades, Nicholas, Poulaki, Vasiliki
Format:	Artikel
Sprache:	eng
Schlagworte:	Anatomy and Pathology/Oncology Animals Apoptosis - drug effects Bridged Bicyclo Compounds, Heterocyclic - pharmacology Cell Cycle Cell Line, Tumor Cell Proliferation Genes, Neoplasm - genetics Melanoma - drug therapy Melanoma - genetics Melanoma - metabolism Mice, Nude Neoplasms, Experimental Pyrimidinones - pharmacology Uveal Neoplasms - drug therapy Uveal Neoplasms - genetics Uveal Neoplasms - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!