Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection
To investigate possible effects of polymorphisms in the 3' UTR region of the locus on susceptibility to hepatitis B virus (HBV) infection and progression of liver diseases among clinically classified Vietnamese patients. Four SNPs (rs13242262A/T, rs77416878C/T, rs10488630A/G, and rs2280714T/C)...
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| Veröffentlicht in: | World journal of gastroenterology : WJG 2018-01, Vol.24 (2), p.248-256 |
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| container_title | World journal of gastroenterology : WJG |
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| creator | Sy, Bui Tien Hoan, Nghiem Xuan Tong, Hoang Van Meyer, Christian G Toan, Nguyen Linh Song, Le Huu Bock, Claus-Thomas Velavan, Thirumalaisamy P |
| description | To investigate possible effects of
polymorphisms in the 3' UTR region of the
locus on susceptibility to hepatitis B virus (HBV) infection and progression of liver diseases among clinically classified Vietnamese patients.
Four
SNPs (rs13242262A/T, rs77416878C/T, rs10488630A/G, and rs2280714T/C) were genotyped in clinically classified HBV patients [chronic hepatitis B (CHB).
= 99; liver cirrhosis (LC),
= 131; hepatocellular carcinoma (HCC),
= 149] and in 242 healthy controls by direct sequencing and TaqMan real-time PCR assays.
Comparing patients and controls, no significant association was observed for the four
variants. However, the alleles
and
contributed to an increased risk of liver cirrhosis (LC
CHB: OR = 1.5, 95%CI: 1.1-2.3, adjusted
= 0.04; LC
CHB: OR = 1.7, 95%CI: 1.1-2.6, adjusted
= 0.019). Haplotype
constructed from 4 SNPs was observed frequently in LC compared to CHB patients (OR = 2.1, 95%CI: 1.2-3.3, adjusted
= 0.008). Haplotype
occurred rather among CHB patients than in the other HBV patient groups (LC
CHB: OR = 0.4, 95%CI: 0.2-0.8, adjusted
= 0.03; HCC
CHB: OR = 0.3, 95%CI: 0.15-0.7, adjusted
= 0.003). The
haplotype was also associated with increased levels of ALT, AST and bilirubin.
Our study shows that
variants may contribute as a host factor in determining the pathogenesis in chronic HBV infections. |
| doi_str_mv | 10.3748/wjg.v24.i2.248 |
| format | Article |
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polymorphisms in the 3' UTR region of the
locus on susceptibility to hepatitis B virus (HBV) infection and progression of liver diseases among clinically classified Vietnamese patients.
Four
SNPs (rs13242262A/T, rs77416878C/T, rs10488630A/G, and rs2280714T/C) were genotyped in clinically classified HBV patients [chronic hepatitis B (CHB).
= 99; liver cirrhosis (LC),
= 131; hepatocellular carcinoma (HCC),
= 149] and in 242 healthy controls by direct sequencing and TaqMan real-time PCR assays.
Comparing patients and controls, no significant association was observed for the four
variants. However, the alleles
and
contributed to an increased risk of liver cirrhosis (LC
CHB: OR = 1.5, 95%CI: 1.1-2.3, adjusted
= 0.04; LC
CHB: OR = 1.7, 95%CI: 1.1-2.6, adjusted
= 0.019). Haplotype
constructed from 4 SNPs was observed frequently in LC compared to CHB patients (OR = 2.1, 95%CI: 1.2-3.3, adjusted
= 0.008). Haplotype
occurred rather among CHB patients than in the other HBV patient groups (LC
CHB: OR = 0.4, 95%CI: 0.2-0.8, adjusted
= 0.03; HCC
CHB: OR = 0.3, 95%CI: 0.15-0.7, adjusted
= 0.003). The
haplotype was also associated with increased levels of ALT, AST and bilirubin.
Our study shows that
variants may contribute as a host factor in determining the pathogenesis in chronic HBV infections.</description><identifier>ISSN: 1007-9327</identifier><identifier>EISSN: 2219-2840</identifier><identifier>DOI: 10.3748/wjg.v24.i2.248</identifier><identifier>PMID: 29375210</identifier><language>eng</language><publisher>United States: Baishideng Publishing Group Inc</publisher><subject>3' Untranslated Regions ; Adolescent ; Adult ; Aged ; Carcinoma, Hepatocellular - diagnosis ; Carcinoma, Hepatocellular - genetics ; Carcinoma, Hepatocellular - virology ; Case Control Study ; Case-Control Studies ; Disease Progression ; Female ; Gene Frequency ; Genetic Association Studies ; Genetic Predisposition to Disease ; Haplotypes ; Hepatitis B, Chronic - diagnosis ; Hepatitis B, Chronic - genetics ; Hepatitis B, Chronic - virology ; Humans ; Interferon Regulatory Factors - genetics ; Liver Cirrhosis - diagnosis ; Liver Cirrhosis - genetics ; Liver Cirrhosis - virology ; Liver Neoplasms - diagnosis ; Liver Neoplasms - genetics ; Liver Neoplasms - virology ; Logistic Models ; Male ; Middle Aged ; Odds Ratio ; Phenotype ; Polymorphism, Single Nucleotide ; Risk Factors ; Vietnam ; Young Adult</subject><ispartof>World journal of gastroenterology : WJG, 2018-01, Vol.24 (2), p.248-256</ispartof><rights>The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-43b7d929c8f3bca2220a67fabb979224bc25484289bfbed935b548fb3b12e9a3</citedby><cites>FETCH-LOGICAL-c390t-43b7d929c8f3bca2220a67fabb979224bc25484289bfbed935b548fb3b12e9a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768943/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5768943/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29375210$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sy, Bui Tien</creatorcontrib><creatorcontrib>Hoan, Nghiem Xuan</creatorcontrib><creatorcontrib>Tong, Hoang Van</creatorcontrib><creatorcontrib>Meyer, Christian G</creatorcontrib><creatorcontrib>Toan, Nguyen Linh</creatorcontrib><creatorcontrib>Song, Le Huu</creatorcontrib><creatorcontrib>Bock, Claus-Thomas</creatorcontrib><creatorcontrib>Velavan, Thirumalaisamy P</creatorcontrib><title>Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection</title><title>World journal of gastroenterology : WJG</title><addtitle>World J Gastroenterol</addtitle><description>To investigate possible effects of
polymorphisms in the 3' UTR region of the
locus on susceptibility to hepatitis B virus (HBV) infection and progression of liver diseases among clinically classified Vietnamese patients.
Four
SNPs (rs13242262A/T, rs77416878C/T, rs10488630A/G, and rs2280714T/C) were genotyped in clinically classified HBV patients [chronic hepatitis B (CHB).
= 99; liver cirrhosis (LC),
= 131; hepatocellular carcinoma (HCC),
= 149] and in 242 healthy controls by direct sequencing and TaqMan real-time PCR assays.
Comparing patients and controls, no significant association was observed for the four
variants. However, the alleles
and
contributed to an increased risk of liver cirrhosis (LC
CHB: OR = 1.5, 95%CI: 1.1-2.3, adjusted
= 0.04; LC
CHB: OR = 1.7, 95%CI: 1.1-2.6, adjusted
= 0.019). Haplotype
constructed from 4 SNPs was observed frequently in LC compared to CHB patients (OR = 2.1, 95%CI: 1.2-3.3, adjusted
= 0.008). Haplotype
occurred rather among CHB patients than in the other HBV patient groups (LC
CHB: OR = 0.4, 95%CI: 0.2-0.8, adjusted
= 0.03; HCC
CHB: OR = 0.3, 95%CI: 0.15-0.7, adjusted
= 0.003). The
haplotype was also associated with increased levels of ALT, AST and bilirubin.
Our study shows that
variants may contribute as a host factor in determining the pathogenesis in chronic HBV infections.</description><subject>3' Untranslated Regions</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Carcinoma, Hepatocellular - diagnosis</subject><subject>Carcinoma, Hepatocellular - genetics</subject><subject>Carcinoma, Hepatocellular - virology</subject><subject>Case Control Study</subject><subject>Case-Control Studies</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Gene Frequency</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Haplotypes</subject><subject>Hepatitis B, Chronic - diagnosis</subject><subject>Hepatitis B, Chronic - genetics</subject><subject>Hepatitis B, Chronic - virology</subject><subject>Humans</subject><subject>Interferon Regulatory Factors - genetics</subject><subject>Liver Cirrhosis - diagnosis</subject><subject>Liver Cirrhosis - genetics</subject><subject>Liver Cirrhosis - virology</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Liver Neoplasms - genetics</subject><subject>Liver Neoplasms - virology</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Phenotype</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Risk Factors</subject><subject>Vietnam</subject><subject>Young Adult</subject><issn>1007-9327</issn><issn>2219-2840</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1rGzEQhkVpqZ001x6Ljr3sRhpps6tLoTX5gkAvuauSPLJl1itXkh3y76MQx7SnYZh3nhl4CPnKWSt6OVw-bVbtAWQboAU5fCBzAK4aGCT7SOacsb5RAvoZOct5wxgI0cFnMgMl-g44m5M_tzhhCY4eTApmKplGT8NUMHlMcaIJV_vRlJieqTeuVtpRk3N0wRRc0qdQ1tSta7Ii1rgzJZSQ6a-K8OhKiNMX8smbMePFsZ6Tx5vrx8Vd8_D79n7x86FxQrHSSGH7pQLlBi-sMwDAzFXvjbWqVwDSOujkIGFQ1ltcKtHZ2nsrLAdURpyTH2_Y3d5ucelwKsmMepfC1qRnHU3Q_0-msNareNBdfzUoKSrg-xGQ4t895qK3ITscRzNh3GfNlRKMC8lZjbZvUZdizgn96Qxn-tWKrlZ0taID6GqlLnz797lT_F2DeAEzZYyC</recordid><startdate>20180114</startdate><enddate>20180114</enddate><creator>Sy, Bui Tien</creator><creator>Hoan, Nghiem Xuan</creator><creator>Tong, Hoang Van</creator><creator>Meyer, Christian G</creator><creator>Toan, Nguyen Linh</creator><creator>Song, Le Huu</creator><creator>Bock, Claus-Thomas</creator><creator>Velavan, Thirumalaisamy P</creator><general>Baishideng Publishing Group Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180114</creationdate><title>Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection</title><author>Sy, Bui Tien ; Hoan, Nghiem Xuan ; Tong, Hoang Van ; Meyer, Christian G ; Toan, Nguyen Linh ; Song, Le Huu ; Bock, Claus-Thomas ; Velavan, Thirumalaisamy P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-43b7d929c8f3bca2220a67fabb979224bc25484289bfbed935b548fb3b12e9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>3' Untranslated Regions</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Carcinoma, Hepatocellular - diagnosis</topic><topic>Carcinoma, Hepatocellular - genetics</topic><topic>Carcinoma, Hepatocellular - virology</topic><topic>Case Control Study</topic><topic>Case-Control Studies</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Gene Frequency</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Haplotypes</topic><topic>Hepatitis B, Chronic - diagnosis</topic><topic>Hepatitis B, Chronic - genetics</topic><topic>Hepatitis B, Chronic - virology</topic><topic>Humans</topic><topic>Interferon Regulatory Factors - genetics</topic><topic>Liver Cirrhosis - diagnosis</topic><topic>Liver Cirrhosis - genetics</topic><topic>Liver Cirrhosis - virology</topic><topic>Liver Neoplasms - diagnosis</topic><topic>Liver Neoplasms - genetics</topic><topic>Liver Neoplasms - virology</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Phenotype</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Risk Factors</topic><topic>Vietnam</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Sy, Bui Tien</creatorcontrib><creatorcontrib>Hoan, Nghiem Xuan</creatorcontrib><creatorcontrib>Tong, Hoang Van</creatorcontrib><creatorcontrib>Meyer, Christian G</creatorcontrib><creatorcontrib>Toan, Nguyen Linh</creatorcontrib><creatorcontrib>Song, Le Huu</creatorcontrib><creatorcontrib>Bock, Claus-Thomas</creatorcontrib><creatorcontrib>Velavan, Thirumalaisamy P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>World journal of gastroenterology : WJG</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sy, Bui Tien</au><au>Hoan, Nghiem Xuan</au><au>Tong, Hoang Van</au><au>Meyer, Christian G</au><au>Toan, Nguyen Linh</au><au>Song, Le Huu</au><au>Bock, Claus-Thomas</au><au>Velavan, Thirumalaisamy P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection</atitle><jtitle>World journal of gastroenterology : WJG</jtitle><addtitle>World J Gastroenterol</addtitle><date>2018-01-14</date><risdate>2018</risdate><volume>24</volume><issue>2</issue><spage>248</spage><epage>256</epage><pages>248-256</pages><issn>1007-9327</issn><eissn>2219-2840</eissn><abstract>To investigate possible effects of
polymorphisms in the 3' UTR region of the
locus on susceptibility to hepatitis B virus (HBV) infection and progression of liver diseases among clinically classified Vietnamese patients.
Four
SNPs (rs13242262A/T, rs77416878C/T, rs10488630A/G, and rs2280714T/C) were genotyped in clinically classified HBV patients [chronic hepatitis B (CHB).
= 99; liver cirrhosis (LC),
= 131; hepatocellular carcinoma (HCC),
= 149] and in 242 healthy controls by direct sequencing and TaqMan real-time PCR assays.
Comparing patients and controls, no significant association was observed for the four
variants. However, the alleles
and
contributed to an increased risk of liver cirrhosis (LC
CHB: OR = 1.5, 95%CI: 1.1-2.3, adjusted
= 0.04; LC
CHB: OR = 1.7, 95%CI: 1.1-2.6, adjusted
= 0.019). Haplotype
constructed from 4 SNPs was observed frequently in LC compared to CHB patients (OR = 2.1, 95%CI: 1.2-3.3, adjusted
= 0.008). Haplotype
occurred rather among CHB patients than in the other HBV patient groups (LC
CHB: OR = 0.4, 95%CI: 0.2-0.8, adjusted
= 0.03; HCC
CHB: OR = 0.3, 95%CI: 0.15-0.7, adjusted
= 0.003). The
haplotype was also associated with increased levels of ALT, AST and bilirubin.
Our study shows that
variants may contribute as a host factor in determining the pathogenesis in chronic HBV infections.</abstract><cop>United States</cop><pub>Baishideng Publishing Group Inc</pub><pmid>29375210</pmid><doi>10.3748/wjg.v24.i2.248</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1007-9327 |
| ispartof | World journal of gastroenterology : WJG, 2018-01, Vol.24 (2), p.248-256 |
| issn | 1007-9327 2219-2840 |
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| source | MEDLINE; Baishideng "World Journal of" online journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | 3' Untranslated Regions Adolescent Adult Aged Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - virology Case Control Study Case-Control Studies Disease Progression Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Haplotypes Hepatitis B, Chronic - diagnosis Hepatitis B, Chronic - genetics Hepatitis B, Chronic - virology Humans Interferon Regulatory Factors - genetics Liver Cirrhosis - diagnosis Liver Cirrhosis - genetics Liver Cirrhosis - virology Liver Neoplasms - diagnosis Liver Neoplasms - genetics Liver Neoplasms - virology Logistic Models Male Middle Aged Odds Ratio Phenotype Polymorphism, Single Nucleotide Risk Factors Vietnam Young Adult |
| title | Genetic variants of interferon regulatory factor 5 associated with chronic hepatitis B infection |
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