Modulation of UVB-induced Carcinogenesis by Activation of Alternative DNA Repair Pathways

The molecular basis for ultraviolet (UV) light-induced nonmelanoma and melanoma skin cancers centers on cumulative genomic instability caused by inefficient DNA repair of dipyrimidine photoproducts. Inefficient DNA repair and subsequent translesion replication past these DNA lesions generate distinc...

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Veröffentlicht in:	Scientific reports 2018-01, Vol.8 (1), p.705-11, Article 705
Hauptverfasser:	Sha, Yan, Vartanian, Vladimir, Owen, Nichole, Mengden Koon, Stephanie J., Calkins, Marcus J., Thompson, Courtney S., Mirafzali, Zahra, Mir, Sara, Goldsmith, Lisa E., He, Huaping, Luo, Chun, Brown, Scott M., Doetsch, Paul W., Kaempf, Andy, Lim, Jeong Y., McCullough, Amanda K., Lloyd, R. Stephen
Format:	Artikel
Sprache:	eng
Schlagworte:	14/1 14/63 631/67/2195 64 64/60 692/4028/67/1813 82 82/16 82/51 82/80 82/83 Basal cell carcinoma Carcinogenesis Carcinoma Deoxyribonucleic acid DNA DNA biosynthesis DNA damage DNA repair Endonuclease Enzymes Genomic instability Hairless Humanities and Social Sciences Keratinocytes Liposomes Localization Melanoma multidisciplinary Pyrimidine dimer glycosylase Science Science (multidisciplinary) Skin cancer Squamous cell carcinoma Tat protein Ultraviolet radiation
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