Model for Porosity Changes Occurring during Ultrasound-Enhanced Transcorneal Drug Delivery
Abstract Ultrasound-enhanced drug delivery through the cornea has considerable therapeutic potential. However, our understanding of how ultrasound enhances drug transport is poor, as is our ability to predict the increased level of transport for given ultrasound parameters. Described here is a compu...
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| Veröffentlicht in: | Ultrasound in medicine & biology 2017-06, Vol.43 (6), p.1223-1236 |
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| container_title | Ultrasound in medicine & biology |
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| creator | Hariharan, Prasanna Nabili, Marjan Guan, Allan Zderic, Vesna Myers, Matthew |
| description | Abstract Ultrasound-enhanced drug delivery through the cornea has considerable therapeutic potential. However, our understanding of how ultrasound enhances drug transport is poor, as is our ability to predict the increased level of transport for given ultrasound parameters. Described here is a computational model for quantifying changes in corneal porosity during ultrasound exposure. The model is calibrated through experiments involving sodium fluorescein transport through rabbit cornea. Validation was performed using nylon filters, for which the properties are known. It was found that exposure to 800-kHz ultrasound at an intensity 2 W/cm2 for 5 min increased the porosity of the epithelium by a factor of 5. The model can be useful for determining the extent to which ultrasound enhances the amount of drug transported through biological barriers, and the time at which a therapeutic dose is achieved at a given location, for different drugs and exposure strategies. |
| doi_str_mv | 10.1016/j.ultrasmedbio.2017.01.013 |
| format | Article |
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However, our understanding of how ultrasound enhances drug transport is poor, as is our ability to predict the increased level of transport for given ultrasound parameters. Described here is a computational model for quantifying changes in corneal porosity during ultrasound exposure. The model is calibrated through experiments involving sodium fluorescein transport through rabbit cornea. Validation was performed using nylon filters, for which the properties are known. It was found that exposure to 800-kHz ultrasound at an intensity 2 W/cm2 for 5 min increased the porosity of the epithelium by a factor of 5. 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However, our understanding of how ultrasound enhances drug transport is poor, as is our ability to predict the increased level of transport for given ultrasound parameters. Described here is a computational model for quantifying changes in corneal porosity during ultrasound exposure. The model is calibrated through experiments involving sodium fluorescein transport through rabbit cornea. Validation was performed using nylon filters, for which the properties are known. It was found that exposure to 800-kHz ultrasound at an intensity 2 W/cm2 for 5 min increased the porosity of the epithelium by a factor of 5. The model can be useful for determining the extent to which ultrasound enhances the amount of drug transported through biological barriers, and the time at which a therapeutic dose is achieved at a given location, for different drugs and exposure strategies.</description><subject>Administration, Ophthalmic</subject><subject>Computer Simulation</subject><subject>Cornea - chemistry</subject><subject>Cornea - radiation effects</subject><subject>Diffusion</subject><subject>Drug delivery</subject><subject>Electroporation - methods</subject><subject>High-Energy Shock Waves</subject><subject>Humans</subject><subject>Models, Biological</subject><subject>Ocular</subject><subject>Pharmaceutical Preparations - administration & dosage</subject><subject>Pharmaceutical Preparations - chemistry</subject><subject>Porosity - radiation effects</subject><subject>Porous medium model</subject><subject>Radiation Dosage</subject><subject>Radiology</subject><subject>Sonication - methods</subject><subject>Ultrasound</subject><issn>0301-5629</issn><issn>1879-291X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUsFu1DAQtRCILoVfQBEnLtmO7SSOOVRCu4UiFRWJVkJcLMeZbL147dberLR_j9MtVeGENPIc5vm90XtDyDsKcwq0OVnPR7eNOm2w72yYM6BiDjQXf0ZmtBWyZJL-eE5mwIGWdcPkEXmV0hoARMPFS3LEWs5rKeWM_PwaenTFEGLxLcSQ7HZfLG60X2EqLo0ZY7R-VfTjfbu-lw2j78szn0EG--Iqap9MiB61K5ZxXBVLdHaHcf-avBi0S_jmoR-T609nV4vz8uLy85fFx4vS1BXblp2uB85p1UjWGqzoUAP0AqREMzQaBdTQ1cK0nawo9IYJjd0gtehwEG3FGD8mpwfe27HLlhj0eUunbqPd6LhXQVv198TbG7UKO1WLpq0qngnePxDEcDdi2qqNTQad0x7DmBRtW8qaOr8Z-uEANdmrFHF4lKGgpnDUWj0NR03hKKC5Jp23Txd9_PonjQxYHgCY7dpZjCoZi5PNNqLZqj7Y_9M5_YfGOOut0e4X7jGtwxh9DkRRlZgC9X06k-lKqOAAVFb8N5miv04</recordid><startdate>20170601</startdate><enddate>20170601</enddate><creator>Hariharan, Prasanna</creator><creator>Nabili, Marjan</creator><creator>Guan, Allan</creator><creator>Zderic, Vesna</creator><creator>Myers, Matthew</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170601</creationdate><title>Model for Porosity Changes Occurring during Ultrasound-Enhanced Transcorneal Drug Delivery</title><author>Hariharan, Prasanna ; Nabili, Marjan ; Guan, Allan ; Zderic, Vesna ; Myers, Matthew</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-ba5f33146928ce41f500d7099ecf6ae7050b57c8b9410dc27aebf9a7bef784223</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Administration, Ophthalmic</topic><topic>Computer Simulation</topic><topic>Cornea - chemistry</topic><topic>Cornea - radiation effects</topic><topic>Diffusion</topic><topic>Drug delivery</topic><topic>Electroporation - methods</topic><topic>High-Energy Shock Waves</topic><topic>Humans</topic><topic>Models, Biological</topic><topic>Ocular</topic><topic>Pharmaceutical Preparations - administration & dosage</topic><topic>Pharmaceutical Preparations - chemistry</topic><topic>Porosity - radiation effects</topic><topic>Porous medium model</topic><topic>Radiation Dosage</topic><topic>Radiology</topic><topic>Sonication - methods</topic><topic>Ultrasound</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hariharan, Prasanna</creatorcontrib><creatorcontrib>Nabili, Marjan</creatorcontrib><creatorcontrib>Guan, Allan</creatorcontrib><creatorcontrib>Zderic, Vesna</creatorcontrib><creatorcontrib>Myers, Matthew</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Ultrasound in medicine & biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hariharan, Prasanna</au><au>Nabili, Marjan</au><au>Guan, Allan</au><au>Zderic, Vesna</au><au>Myers, Matthew</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Model for Porosity Changes Occurring during Ultrasound-Enhanced Transcorneal Drug Delivery</atitle><jtitle>Ultrasound in medicine & biology</jtitle><addtitle>Ultrasound Med Biol</addtitle><date>2017-06-01</date><risdate>2017</risdate><volume>43</volume><issue>6</issue><spage>1223</spage><epage>1236</epage><pages>1223-1236</pages><issn>0301-5629</issn><eissn>1879-291X</eissn><abstract>Abstract Ultrasound-enhanced drug delivery through the cornea has considerable therapeutic potential. 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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Administration, Ophthalmic Computer Simulation Cornea - chemistry Cornea - radiation effects Diffusion Drug delivery Electroporation - methods High-Energy Shock Waves Humans Models, Biological Ocular Pharmaceutical Preparations - administration & dosage Pharmaceutical Preparations - chemistry Porosity - radiation effects Porous medium model Radiation Dosage Radiology Sonication - methods Ultrasound |
| title | Model for Porosity Changes Occurring during Ultrasound-Enhanced Transcorneal Drug Delivery |
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