Episode-like pulse testosterone supplementation induces tumor senescence and growth arrest down-modulating androgen receptor through modulation of p-ERK1/2, pARser81 and CDK1 signaling: biological implications for men treated with testosterone replacement therapy

Despite the growing body of knowledge showing that testosterone (T) may not significantly affect tumor progression in hypogonadal patients treated for prostate cancer (Pca), the use of this hormone in this population still remains controversial. The effects of continuous or pulsed T stimulation were...

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Veröffentlicht in:	Oncotarget 2017-12, Vol.8 (69), p.113792-113806
Hauptverfasser:	Gravina, Giovanni Luca, Marampon, Francesco, Sanità, Patrizia, Festuccia, Claudio, Forcella, Chiara, Scarsella, Luca, Jitariuc, Anna, Vetuschi, Antonella, Sferra, Roberta, Colapietro, Alessandro, Carosa, Eleonora, Dolci, Susanna, Lenzi, Andrea, Jannini, Emmanuele A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Research Paper
Online-Zugang:	Volltext
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