Pathophysiology, clinical presentation, and treatment of coma and acute kidney injury complicating falciparum malaria

PURPOSE OF REVIEWCerebral impairment and acute kidney injury (AKI) are independent predictors of mortality in both adults and children with severe falciparum malaria. In this review, we present recent advances in understanding the pathophysiology, clinical features, and management of these complicat...

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Veröffentlicht in:	Current opinion in infectious diseases 2018-02, Vol.31 (1), p.69-77
Hauptverfasser:	Plewes, Katherine, Turner, Gareth D.H, Dondorp, Arjen M
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - administration & dosage Acute Kidney Injury - pathology Acute Kidney Injury - physiopathology Acute Kidney Injury - therapy Animals Anti-Inflammatory Agents - administration & dosage Antioxidants - administration & dosage Brain - diagnostic imaging Brain - pathology CNS INFECTIONS: Edited by Matthijs C. Brouwer Coma - pathology Coma - physiopathology Coma - therapy Dexamethasone - administration & dosage Disease Models, Animal Humans Kidney - pathology Malaria, Falciparum - complications Mannitol - administration & dosage Oxidative Stress Treatment Outcome
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