Neurocognitive Dysfunction in Hematopoietic Cell Transplant Recipients: Expert Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Complications and Quality of Life Working Party of the European Society for Blood and Marrow Transplantation
•Understanding neurocognitive dysfunction of HCT is evolving.•Standardization of how to define and assess neurocognitive dysfunction is needed.•Future neurocognitive dysfunction research is needed among diverse HCT populations.•HCT neurocognitive dysfunction assessment and treatment are not well elu...
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| Veröffentlicht in: | Biology of blood and marrow transplantation 2018-02, Vol.24 (2), p.228-241 |
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| creator | Kelly, Debra Lynch Buchbinder, David Duarte, Rafael F. Auletta, Jeffrey J. Bhatt, Neel Byrne, Michael DeFilipp, Zachariah Gabriel, Melissa Mahindra, Anuj Norkin, Maxim Schoemans, Helene Shah, Ami J. Ahmed, Ibrahim Atsuta, Yoshiko Basak, Grzegorz W. Beattie, Sara Bhella, Sita Bredeson, Christopher Bunin, Nancy Dalal, Jignesh Daly, Andrew Gajewski, James Gale, Robert Peter Galvin, John Hamadani, Mehdi Hayashi, Robert J. Adekola, Kehinde Law, Jason Lee, Catherine J. Liesveld, Jane Malone, Adriana K. Nagler, Arnon Naik, Seema Nishihori, Taiga Parsons, Susan K. Scherwath, Angela Schofield, Hannah-Lise Soiffer, Robert Szer, Jeff Twist, Ida Warwick, Anne Wirk, Baldeep M. Yi, Jean Battiwalla, Minoo Flowers, Mary E. Savani, Bipin Shaw, Bronwen E. |
| description | •Understanding neurocognitive dysfunction of HCT is evolving.•Standardization of how to define and assess neurocognitive dysfunction is needed.•Future neurocognitive dysfunction research is needed among diverse HCT populations.•HCT neurocognitive dysfunction assessment and treatment are not well elucidated.•More research is needed to accurately characterize neurocognitive dysfunction.
Hematopoietic cell transplantation (HCT) is a potentially curative treatment for children and adults with malignant and nonmalignant diseases. Despite increasing survival rates, long-term morbidity after HCT is substantial. Neurocognitive dysfunction is a serious cause of morbidity, yet little is known about neurocognitive dysfunction after HCT. To address this gap, collaborative efforts of the Center for International Blood and Marrow Transplant Research and the European Society for Blood and Marrow Transplantation undertook an expert review of neurocognitive dysfunction after HCT. In this review we define what constitutes neurocognitive dysfunction, characterize its risk factors and sequelae, describe tools and methods to assess neurocognitive function in HCT recipients, and discuss possible interventions for HCT patients with this condition. This review aims to help clinicians understand the scope of this health-related problem, highlight its impact on well-being of survivors, and help determine factors that may improve identification of patients at risk for declines in cognitive functioning after HCT. In particular, we review strategies for preventing and treating neurocognitive dysfunction in HCT patients. Finally, we highlight the need for well-designed studies to develop and test interventions aimed at preventing and improving neurocognitive dysfunction and its sequelae after HCT. |
| doi_str_mv | 10.1016/j.bbmt.2017.09.004 |
| format | Article |
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Hematopoietic cell transplantation (HCT) is a potentially curative treatment for children and adults with malignant and nonmalignant diseases. Despite increasing survival rates, long-term morbidity after HCT is substantial. Neurocognitive dysfunction is a serious cause of morbidity, yet little is known about neurocognitive dysfunction after HCT. To address this gap, collaborative efforts of the Center for International Blood and Marrow Transplant Research and the European Society for Blood and Marrow Transplantation undertook an expert review of neurocognitive dysfunction after HCT. In this review we define what constitutes neurocognitive dysfunction, characterize its risk factors and sequelae, describe tools and methods to assess neurocognitive function in HCT recipients, and discuss possible interventions for HCT patients with this condition. This review aims to help clinicians understand the scope of this health-related problem, highlight its impact on well-being of survivors, and help determine factors that may improve identification of patients at risk for declines in cognitive functioning after HCT. In particular, we review strategies for preventing and treating neurocognitive dysfunction in HCT patients. Finally, we highlight the need for well-designed studies to develop and test interventions aimed at preventing and improving neurocognitive dysfunction and its sequelae after HCT.</description><identifier>ISSN: 1083-8791</identifier><identifier>EISSN: 1523-6536</identifier><identifier>DOI: 10.1016/j.bbmt.2017.09.004</identifier><identifier>PMID: 28939455</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Biomarkers ; Bone marrow transplantation ; Cognition ; Cognitive function ; Hematology oncology ; Hematopoietic cell transplantation ; Hematopoietic Stem Cell Transplantation - adverse effects ; Humans ; Neurocognitive Disorders - diagnosis ; Neurocognitive Disorders - etiology ; Neurocognitive Disorders - prevention & control ; Neurocognitive Disorders - therapy ; Neurocognitive dysfunction ; Prevalence ; Risk Factors</subject><ispartof>Biology of blood and marrow transplantation, 2018-02, Vol.24 (2), p.228-241</ispartof><rights>2017 The American Society for Blood and Marrow Transplantation</rights><rights>Copyright © 2017 The American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-8fb5113b78349d9ffba36fe0456d48dcf94ee8ff90cb69852cc2a168fc000a3f3</citedby><cites>FETCH-LOGICAL-c521t-8fb5113b78349d9ffba36fe0456d48dcf94ee8ff90cb69852cc2a168fc000a3f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.bbmt.2017.09.004$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28939455$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kelly, Debra Lynch</creatorcontrib><creatorcontrib>Buchbinder, David</creatorcontrib><creatorcontrib>Duarte, Rafael F.</creatorcontrib><creatorcontrib>Auletta, Jeffrey J.</creatorcontrib><creatorcontrib>Bhatt, Neel</creatorcontrib><creatorcontrib>Byrne, Michael</creatorcontrib><creatorcontrib>DeFilipp, Zachariah</creatorcontrib><creatorcontrib>Gabriel, Melissa</creatorcontrib><creatorcontrib>Mahindra, Anuj</creatorcontrib><creatorcontrib>Norkin, Maxim</creatorcontrib><creatorcontrib>Schoemans, Helene</creatorcontrib><creatorcontrib>Shah, Ami J.</creatorcontrib><creatorcontrib>Ahmed, Ibrahim</creatorcontrib><creatorcontrib>Atsuta, Yoshiko</creatorcontrib><creatorcontrib>Basak, Grzegorz W.</creatorcontrib><creatorcontrib>Beattie, Sara</creatorcontrib><creatorcontrib>Bhella, Sita</creatorcontrib><creatorcontrib>Bredeson, Christopher</creatorcontrib><creatorcontrib>Bunin, Nancy</creatorcontrib><creatorcontrib>Dalal, Jignesh</creatorcontrib><creatorcontrib>Daly, Andrew</creatorcontrib><creatorcontrib>Gajewski, James</creatorcontrib><creatorcontrib>Gale, Robert Peter</creatorcontrib><creatorcontrib>Galvin, John</creatorcontrib><creatorcontrib>Hamadani, Mehdi</creatorcontrib><creatorcontrib>Hayashi, Robert J.</creatorcontrib><creatorcontrib>Adekola, Kehinde</creatorcontrib><creatorcontrib>Law, Jason</creatorcontrib><creatorcontrib>Lee, Catherine J.</creatorcontrib><creatorcontrib>Liesveld, Jane</creatorcontrib><creatorcontrib>Malone, Adriana K.</creatorcontrib><creatorcontrib>Nagler, Arnon</creatorcontrib><creatorcontrib>Naik, Seema</creatorcontrib><creatorcontrib>Nishihori, Taiga</creatorcontrib><creatorcontrib>Parsons, Susan K.</creatorcontrib><creatorcontrib>Scherwath, Angela</creatorcontrib><creatorcontrib>Schofield, Hannah-Lise</creatorcontrib><creatorcontrib>Soiffer, Robert</creatorcontrib><creatorcontrib>Szer, Jeff</creatorcontrib><creatorcontrib>Twist, Ida</creatorcontrib><creatorcontrib>Warwick, Anne</creatorcontrib><creatorcontrib>Wirk, Baldeep M.</creatorcontrib><creatorcontrib>Yi, Jean</creatorcontrib><creatorcontrib>Battiwalla, Minoo</creatorcontrib><creatorcontrib>Flowers, Mary E.</creatorcontrib><creatorcontrib>Savani, Bipin</creatorcontrib><creatorcontrib>Shaw, Bronwen E.</creatorcontrib><title>Neurocognitive Dysfunction in Hematopoietic Cell Transplant Recipients: Expert Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Complications and Quality of Life Working Party of the European Society for Blood and Marrow Transplantation</title><title>Biology of blood and marrow transplantation</title><addtitle>Biol Blood Marrow Transplant</addtitle><description>•Understanding neurocognitive dysfunction of HCT is evolving.•Standardization of how to define and assess neurocognitive dysfunction is needed.•Future neurocognitive dysfunction research is needed among diverse HCT populations.•HCT neurocognitive dysfunction assessment and treatment are not well elucidated.•More research is needed to accurately characterize neurocognitive dysfunction.
Hematopoietic cell transplantation (HCT) is a potentially curative treatment for children and adults with malignant and nonmalignant diseases. Despite increasing survival rates, long-term morbidity after HCT is substantial. Neurocognitive dysfunction is a serious cause of morbidity, yet little is known about neurocognitive dysfunction after HCT. To address this gap, collaborative efforts of the Center for International Blood and Marrow Transplant Research and the European Society for Blood and Marrow Transplantation undertook an expert review of neurocognitive dysfunction after HCT. In this review we define what constitutes neurocognitive dysfunction, characterize its risk factors and sequelae, describe tools and methods to assess neurocognitive function in HCT recipients, and discuss possible interventions for HCT patients with this condition. This review aims to help clinicians understand the scope of this health-related problem, highlight its impact on well-being of survivors, and help determine factors that may improve identification of patients at risk for declines in cognitive functioning after HCT. In particular, we review strategies for preventing and treating neurocognitive dysfunction in HCT patients. Finally, we highlight the need for well-designed studies to develop and test interventions aimed at preventing and improving neurocognitive dysfunction and its sequelae after HCT.</description><subject>Biomarkers</subject><subject>Bone marrow transplantation</subject><subject>Cognition</subject><subject>Cognitive function</subject><subject>Hematology oncology</subject><subject>Hematopoietic cell transplantation</subject><subject>Hematopoietic Stem Cell Transplantation - adverse effects</subject><subject>Humans</subject><subject>Neurocognitive Disorders - diagnosis</subject><subject>Neurocognitive Disorders - etiology</subject><subject>Neurocognitive Disorders - prevention & control</subject><subject>Neurocognitive Disorders - therapy</subject><subject>Neurocognitive dysfunction</subject><subject>Prevalence</subject><subject>Risk 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Mary E.</au><au>Savani, Bipin</au><au>Shaw, Bronwen E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurocognitive Dysfunction in Hematopoietic Cell Transplant Recipients: Expert Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Complications and Quality of Life Working Party of the European Society for Blood and Marrow Transplantation</atitle><jtitle>Biology of blood and marrow transplantation</jtitle><addtitle>Biol Blood Marrow Transplant</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>24</volume><issue>2</issue><spage>228</spage><epage>241</epage><pages>228-241</pages><issn>1083-8791</issn><eissn>1523-6536</eissn><abstract>•Understanding neurocognitive dysfunction of HCT is evolving.•Standardization of how to define and assess neurocognitive dysfunction is needed.•Future neurocognitive dysfunction research is needed among diverse HCT populations.•HCT neurocognitive dysfunction assessment and treatment are not well elucidated.•More research is needed to accurately characterize neurocognitive dysfunction.
Hematopoietic cell transplantation (HCT) is a potentially curative treatment for children and adults with malignant and nonmalignant diseases. Despite increasing survival rates, long-term morbidity after HCT is substantial. Neurocognitive dysfunction is a serious cause of morbidity, yet little is known about neurocognitive dysfunction after HCT. To address this gap, collaborative efforts of the Center for International Blood and Marrow Transplant Research and the European Society for Blood and Marrow Transplantation undertook an expert review of neurocognitive dysfunction after HCT. In this review we define what constitutes neurocognitive dysfunction, characterize its risk factors and sequelae, describe tools and methods to assess neurocognitive function in HCT recipients, and discuss possible interventions for HCT patients with this condition. This review aims to help clinicians understand the scope of this health-related problem, highlight its impact on well-being of survivors, and help determine factors that may improve identification of patients at risk for declines in cognitive functioning after HCT. In particular, we review strategies for preventing and treating neurocognitive dysfunction in HCT patients. Finally, we highlight the need for well-designed studies to develop and test interventions aimed at preventing and improving neurocognitive dysfunction and its sequelae after HCT.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28939455</pmid><doi>10.1016/j.bbmt.2017.09.004</doi><tpages>14</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1083-8791 |
| ispartof | Biology of blood and marrow transplantation, 2018-02, Vol.24 (2), p.228-241 |
| issn | 1083-8791 1523-6536 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5768142 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present); Alma/SFX Local Collection |
| subjects | Biomarkers Bone marrow transplantation Cognition Cognitive function Hematology oncology Hematopoietic cell transplantation Hematopoietic Stem Cell Transplantation - adverse effects Humans Neurocognitive Disorders - diagnosis Neurocognitive Disorders - etiology Neurocognitive Disorders - prevention & control Neurocognitive Disorders - therapy Neurocognitive dysfunction Prevalence Risk Factors |
| title | Neurocognitive Dysfunction in Hematopoietic Cell Transplant Recipients: Expert Review from the Late Effects and Quality of Life Working Committee of the Center for International Blood and Marrow Transplant Research and Complications and Quality of Life Working Party of the European Society for Blood and Marrow Transplantation |
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