MicroRNA-302a suppresses influenza A virus–stimulated interferon regulatory factor-5 expression and cytokine storm induction

During influenza A virus (IAV) infection, cytokine storms play a vital and critical role in clinical outcomes. We have previously reported that microRNA (miR)-302c regulates IAV-induced IFN expression by targeting the 3′-UTR of nuclear factor κB (NF-κB)–inducing kinase. In the current study, we foun...

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Veröffentlicht in:	The Journal of biological chemistry 2017-12, Vol.292 (52), p.21291-21303
Hauptverfasser:	Chen, Xueyuan, Zhou, Li, Peng, Nanfang, Yu, Haisheng, Li, Mengqi, Cao, Zhongying, Lin, Yong, Wang, Xueyu, Li, Qian, Wang, Jun, She, Yinglong, Zhu, Chengliang, Lu, Mengji, Zhu, Ying, Liu, Shi
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Animals cytokine induction cytokine storm Disease Models, Animal Dogs Down-Regulation HEK293 Cells Host-Pathogen Interactions Humans Immune Evasion Influenza A Virus, H1N1 Subtype - genetics Influenza A Virus, H1N1 Subtype - immunology Influenza A Virus, H1N1 Subtype - metabolism Influenza A Virus, H1N1 Subtype - physiology influenza virus Influenza, Human - genetics Influenza, Human - immunology Influenza, Human - metabolism Influenza, Human - virology interferon regulatory factor (IRF) Interferon Regulatory Factors - biosynthesis Interferon Regulatory Factors - genetics Interferon Regulatory Factors - immunology Interferon Regulatory Factors - metabolism Madin Darby Canine Kidney Cells Mice Mice, Inbred C57BL microRNA (miRNA) MicroRNAs - genetics MicroRNAs - immunology MicroRNAs - metabolism NF-kappa B - immunology NF-kappa B - metabolism Orthomyxoviridae Infections - genetics Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - metabolism Orthomyxoviridae Infections - virology Signal Transduction signaling Virus Replication
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