Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle performance
SRP-35 is a short-chain dehydrogenase/reductase belonging to the DHRS7C dehydrogenase/ reductase family 7. Here we show that its over-expression in mouse skeletal muscles induces enhanced muscle performance in vivo , which is not related to alterations in excitation-contraction coupling but rather l...
Gespeichert in:
| Veröffentlicht in: | Scientific reports 2018-01, Vol.8 (1), p.636-14, Article 636 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 14 |
|---|---|
| container_issue | 1 |
| container_start_page | 636 |
| container_title | Scientific reports |
| container_volume | 8 |
| creator | Ruiz, Alexis Dror, Erez Handschin, Christoph Furrer, Regula Perez-Schindler, Joaquin Bachmann, Christoph Treves, Susan Zorzato, Francesco |
| description | SRP-35 is a short-chain dehydrogenase/reductase belonging to the DHRS7C dehydrogenase/ reductase family 7. Here we show that its over-expression in mouse skeletal muscles induces enhanced muscle performance
in vivo
, which is not related to alterations in excitation-contraction coupling but rather linked to enhanced glucose metabolism. Over-expression of SRP-35 causes increased phosphorylation of Akt
S473
, triggering plasmalemmal targeting of GLUT4 and higher glucose uptake into muscles. SRP-35 signaling involves RARα and RARγ (non-genomic effect), PI3K and mTORC2. We also demonstrate that all-trans retinoic acid, a downstream product of the enzymatic activity of SRP-35, mimics the effect of SRP-35 in skeletal muscle, inducing a synergistic effect with insulin on AKT
S473
phosphorylation. These results indicate that SRP-35 affects skeletal muscle metabolism and may represent an important target for the treatment of metabolic diseases. |
| doi_str_mv | 10.1038/s41598-017-18844-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5766524</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1986974494</sourcerecordid><originalsourceid>FETCH-LOGICAL-c414t-c62019836a6cafe2a7a4dc7b2c4a23b5633e8e085d35214fd6b75c196a9d6daf3</originalsourceid><addsrcrecordid>eNp1kd1q3DAQhU1paEKaF-hFEfQmhbrRv62bQtn-JBDYskmvhSyPd53K0kayl-Yx-sbVZpOwKVQ3EprvnJnhFMUbgj8SzOqzxIlQdYlJVZK65rxkL4ojirkoKaP05d77sDhJ6QbnI6jiRL0qDqliDAssjoo_8w3EEn6vI6TUB49ChwyKMPY-ONTC6q6NYQneJECnV4sfTJx9OV9cVbP3qPco_QIHo3FomJJ1gIwd-40ZIaHher6Y0Q8I_Mp4mz-WbrIhmwyZb4Lr04CMbx-Fa4hdiMMWfV0cdMYlOHm4j4uf375ez87Ly_n3i9nny9JywsfSSoqJqpk00poOqKkMb23VUMsNZY2QjEENuBYtE5TwrpVNJSxR0qhWtqZjx8Wnne96agZoLfgxGqfXsR9MvNPB9Pp5xfcrvQwbLSopBeXZ4PTBIIbbCdKohz5ZcM54CFPSeTolaip4ldF3_6A3YYo-r7elpKo4V1tDuqNsDClF6J6GIVhvQ9e70HUOXd-HrlkWvd1f40nyGHEG2A5IueSXEPd6_9_2L37GuV0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1986974494</pqid></control><display><type>article</type><title>Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle performance</title><source>Nature Open Access</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><source>Springer Nature OA Free Journals</source><creator>Ruiz, Alexis ; Dror, Erez ; Handschin, Christoph ; Furrer, Regula ; Perez-Schindler, Joaquin ; Bachmann, Christoph ; Treves, Susan ; Zorzato, Francesco</creator><creatorcontrib>Ruiz, Alexis ; Dror, Erez ; Handschin, Christoph ; Furrer, Regula ; Perez-Schindler, Joaquin ; Bachmann, Christoph ; Treves, Susan ; Zorzato, Francesco</creatorcontrib><description>SRP-35 is a short-chain dehydrogenase/reductase belonging to the DHRS7C dehydrogenase/ reductase family 7. Here we show that its over-expression in mouse skeletal muscles induces enhanced muscle performance
in vivo
, which is not related to alterations in excitation-contraction coupling but rather linked to enhanced glucose metabolism. Over-expression of SRP-35 causes increased phosphorylation of Akt
S473
, triggering plasmalemmal targeting of GLUT4 and higher glucose uptake into muscles. SRP-35 signaling involves RARα and RARγ (non-genomic effect), PI3K and mTORC2. We also demonstrate that all-trans retinoic acid, a downstream product of the enzymatic activity of SRP-35, mimics the effect of SRP-35 in skeletal muscle, inducing a synergistic effect with insulin on AKT
S473
phosphorylation. These results indicate that SRP-35 affects skeletal muscle metabolism and may represent an important target for the treatment of metabolic diseases.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-017-18844-3</identifier><identifier>PMID: 29330505</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>1-Phosphatidylinositol 3-kinase ; 13 ; 631/443/319/1557 ; 631/45 ; 64 ; 64/110 ; 82 ; 82/1 ; 96 ; Animals ; Contraction ; Dehydrogenase ; Dehydrogenases ; Enzymatic activity ; Excitation-contraction coupling ; Gene Expression ; Glucose ; Glucose - metabolism ; Glucose Transporter Type 4 - metabolism ; Humanities and Social Sciences ; Insulin ; Male ; MAP Kinase Signaling System ; Mechanistic Target of Rapamycin Complex 2 - metabolism ; Metabolic disorders ; Metabolism ; Mice ; Mice, Transgenic ; multidisciplinary ; Muscle, Skeletal - physiology ; Muscles ; Musculoskeletal system ; Overexpression ; Oxidoreductases - genetics ; Oxidoreductases - metabolism ; Phosphorylation ; Receptors, Retinoic Acid ; Reductase ; Retinoic acid ; Retinoic Acid Receptor alpha - metabolism ; Retinol dehydrogenase ; Science ; Science (multidisciplinary) ; Skeletal muscle ; Synergistic effect ; Vitamin A</subject><ispartof>Scientific reports, 2018-01, Vol.8 (1), p.636-14, Article 636</ispartof><rights>The Author(s) 2018</rights><rights>2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c414t-c62019836a6cafe2a7a4dc7b2c4a23b5633e8e085d35214fd6b75c196a9d6daf3</cites><orcidid>0000-0003-0603-1097</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766524/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766524/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29330505$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ruiz, Alexis</creatorcontrib><creatorcontrib>Dror, Erez</creatorcontrib><creatorcontrib>Handschin, Christoph</creatorcontrib><creatorcontrib>Furrer, Regula</creatorcontrib><creatorcontrib>Perez-Schindler, Joaquin</creatorcontrib><creatorcontrib>Bachmann, Christoph</creatorcontrib><creatorcontrib>Treves, Susan</creatorcontrib><creatorcontrib>Zorzato, Francesco</creatorcontrib><title>Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle performance</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>SRP-35 is a short-chain dehydrogenase/reductase belonging to the DHRS7C dehydrogenase/ reductase family 7. Here we show that its over-expression in mouse skeletal muscles induces enhanced muscle performance
in vivo
, which is not related to alterations in excitation-contraction coupling but rather linked to enhanced glucose metabolism. Over-expression of SRP-35 causes increased phosphorylation of Akt
S473
, triggering plasmalemmal targeting of GLUT4 and higher glucose uptake into muscles. SRP-35 signaling involves RARα and RARγ (non-genomic effect), PI3K and mTORC2. We also demonstrate that all-trans retinoic acid, a downstream product of the enzymatic activity of SRP-35, mimics the effect of SRP-35 in skeletal muscle, inducing a synergistic effect with insulin on AKT
S473
phosphorylation. These results indicate that SRP-35 affects skeletal muscle metabolism and may represent an important target for the treatment of metabolic diseases.</description><subject>1-Phosphatidylinositol 3-kinase</subject><subject>13</subject><subject>631/443/319/1557</subject><subject>631/45</subject><subject>64</subject><subject>64/110</subject><subject>82</subject><subject>82/1</subject><subject>96</subject><subject>Animals</subject><subject>Contraction</subject><subject>Dehydrogenase</subject><subject>Dehydrogenases</subject><subject>Enzymatic activity</subject><subject>Excitation-contraction coupling</subject><subject>Gene Expression</subject><subject>Glucose</subject><subject>Glucose - metabolism</subject><subject>Glucose Transporter Type 4 - metabolism</subject><subject>Humanities and Social Sciences</subject><subject>Insulin</subject><subject>Male</subject><subject>MAP Kinase Signaling System</subject><subject>Mechanistic Target of Rapamycin Complex 2 - metabolism</subject><subject>Metabolic disorders</subject><subject>Metabolism</subject><subject>Mice</subject><subject>Mice, Transgenic</subject><subject>multidisciplinary</subject><subject>Muscle, Skeletal - physiology</subject><subject>Muscles</subject><subject>Musculoskeletal system</subject><subject>Overexpression</subject><subject>Oxidoreductases - genetics</subject><subject>Oxidoreductases - metabolism</subject><subject>Phosphorylation</subject><subject>Receptors, Retinoic Acid</subject><subject>Reductase</subject><subject>Retinoic acid</subject><subject>Retinoic Acid Receptor alpha - metabolism</subject><subject>Retinol dehydrogenase</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Skeletal muscle</subject><subject>Synergistic effect</subject><subject>Vitamin A</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kd1q3DAQhU1paEKaF-hFEfQmhbrRv62bQtn-JBDYskmvhSyPd53K0kayl-Yx-sbVZpOwKVQ3EprvnJnhFMUbgj8SzOqzxIlQdYlJVZK65rxkL4ojirkoKaP05d77sDhJ6QbnI6jiRL0qDqliDAssjoo_8w3EEn6vI6TUB49ChwyKMPY-ONTC6q6NYQneJECnV4sfTJx9OV9cVbP3qPco_QIHo3FomJJ1gIwd-40ZIaHher6Y0Q8I_Mp4mz-WbrIhmwyZb4Lr04CMbx-Fa4hdiMMWfV0cdMYlOHm4j4uf375ez87Ly_n3i9nny9JywsfSSoqJqpk00poOqKkMb23VUMsNZY2QjEENuBYtE5TwrpVNJSxR0qhWtqZjx8Wnne96agZoLfgxGqfXsR9MvNPB9Pp5xfcrvQwbLSopBeXZ4PTBIIbbCdKohz5ZcM54CFPSeTolaip4ldF3_6A3YYo-r7elpKo4V1tDuqNsDClF6J6GIVhvQ9e70HUOXd-HrlkWvd1f40nyGHEG2A5IueSXEPd6_9_2L37GuV0</recordid><startdate>20180112</startdate><enddate>20180112</enddate><creator>Ruiz, Alexis</creator><creator>Dror, Erez</creator><creator>Handschin, Christoph</creator><creator>Furrer, Regula</creator><creator>Perez-Schindler, Joaquin</creator><creator>Bachmann, Christoph</creator><creator>Treves, Susan</creator><creator>Zorzato, Francesco</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0603-1097</orcidid></search><sort><creationdate>20180112</creationdate><title>Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle performance</title><author>Ruiz, Alexis ; Dror, Erez ; Handschin, Christoph ; Furrer, Regula ; Perez-Schindler, Joaquin ; Bachmann, Christoph ; Treves, Susan ; Zorzato, Francesco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-c62019836a6cafe2a7a4dc7b2c4a23b5633e8e085d35214fd6b75c196a9d6daf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>1-Phosphatidylinositol 3-kinase</topic><topic>13</topic><topic>631/443/319/1557</topic><topic>631/45</topic><topic>64</topic><topic>64/110</topic><topic>82</topic><topic>82/1</topic><topic>96</topic><topic>Animals</topic><topic>Contraction</topic><topic>Dehydrogenase</topic><topic>Dehydrogenases</topic><topic>Enzymatic activity</topic><topic>Excitation-contraction coupling</topic><topic>Gene Expression</topic><topic>Glucose</topic><topic>Glucose - metabolism</topic><topic>Glucose Transporter Type 4 - metabolism</topic><topic>Humanities and Social Sciences</topic><topic>Insulin</topic><topic>Male</topic><topic>MAP Kinase Signaling System</topic><topic>Mechanistic Target of Rapamycin Complex 2 - metabolism</topic><topic>Metabolic disorders</topic><topic>Metabolism</topic><topic>Mice</topic><topic>Mice, Transgenic</topic><topic>multidisciplinary</topic><topic>Muscle, Skeletal - physiology</topic><topic>Muscles</topic><topic>Musculoskeletal system</topic><topic>Overexpression</topic><topic>Oxidoreductases - genetics</topic><topic>Oxidoreductases - metabolism</topic><topic>Phosphorylation</topic><topic>Receptors, Retinoic Acid</topic><topic>Reductase</topic><topic>Retinoic acid</topic><topic>Retinoic Acid Receptor alpha - metabolism</topic><topic>Retinol dehydrogenase</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Skeletal muscle</topic><topic>Synergistic effect</topic><topic>Vitamin A</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ruiz, Alexis</creatorcontrib><creatorcontrib>Dror, Erez</creatorcontrib><creatorcontrib>Handschin, Christoph</creatorcontrib><creatorcontrib>Furrer, Regula</creatorcontrib><creatorcontrib>Perez-Schindler, Joaquin</creatorcontrib><creatorcontrib>Bachmann, Christoph</creatorcontrib><creatorcontrib>Treves, Susan</creatorcontrib><creatorcontrib>Zorzato, Francesco</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ruiz, Alexis</au><au>Dror, Erez</au><au>Handschin, Christoph</au><au>Furrer, Regula</au><au>Perez-Schindler, Joaquin</au><au>Bachmann, Christoph</au><au>Treves, Susan</au><au>Zorzato, Francesco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle performance</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2018-01-12</date><risdate>2018</risdate><volume>8</volume><issue>1</issue><spage>636</spage><epage>14</epage><pages>636-14</pages><artnum>636</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>SRP-35 is a short-chain dehydrogenase/reductase belonging to the DHRS7C dehydrogenase/ reductase family 7. Here we show that its over-expression in mouse skeletal muscles induces enhanced muscle performance
in vivo
, which is not related to alterations in excitation-contraction coupling but rather linked to enhanced glucose metabolism. Over-expression of SRP-35 causes increased phosphorylation of Akt
S473
, triggering plasmalemmal targeting of GLUT4 and higher glucose uptake into muscles. SRP-35 signaling involves RARα and RARγ (non-genomic effect), PI3K and mTORC2. We also demonstrate that all-trans retinoic acid, a downstream product of the enzymatic activity of SRP-35, mimics the effect of SRP-35 in skeletal muscle, inducing a synergistic effect with insulin on AKT
S473
phosphorylation. These results indicate that SRP-35 affects skeletal muscle metabolism and may represent an important target for the treatment of metabolic diseases.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29330505</pmid><doi>10.1038/s41598-017-18844-3</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-0603-1097</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2045-2322 |
| ispartof | Scientific reports, 2018-01, Vol.8 (1), p.636-14, Article 636 |
| issn | 2045-2322 2045-2322 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5766524 |
| source | Nature Open Access; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry; Springer Nature OA Free Journals |
| subjects | 1-Phosphatidylinositol 3-kinase 13 631/443/319/1557 631/45 64 64/110 82 82/1 96 Animals Contraction Dehydrogenase Dehydrogenases Enzymatic activity Excitation-contraction coupling Gene Expression Glucose Glucose - metabolism Glucose Transporter Type 4 - metabolism Humanities and Social Sciences Insulin Male MAP Kinase Signaling System Mechanistic Target of Rapamycin Complex 2 - metabolism Metabolic disorders Metabolism Mice Mice, Transgenic multidisciplinary Muscle, Skeletal - physiology Muscles Musculoskeletal system Overexpression Oxidoreductases - genetics Oxidoreductases - metabolism Phosphorylation Receptors, Retinoic Acid Reductase Retinoic acid Retinoic Acid Receptor alpha - metabolism Retinol dehydrogenase Science Science (multidisciplinary) Skeletal muscle Synergistic effect Vitamin A |
| title | Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle performance |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-15T04%3A09%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Over-expression%20of%20a%20retinol%20dehydrogenase%20(SRP35/DHRS7C)%20in%20skeletal%20muscle%20activates%20mTORC2,%20enhances%20glucose%20metabolism%20and%20muscle%20performance&rft.jtitle=Scientific%20reports&rft.au=Ruiz,%20Alexis&rft.date=2018-01-12&rft.volume=8&rft.issue=1&rft.spage=636&rft.epage=14&rft.pages=636-14&rft.artnum=636&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/s41598-017-18844-3&rft_dat=%3Cproquest_pubme%3E1986974494%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1986974494&rft_id=info:pmid/29330505&rfr_iscdi=true |