A Study of Microalbuminuria (MAU) and Advanced Glycation End Products (AGEs) Levels in Diabetic and Hypertensive Subjects
The prevalence of non-communicable diseases like diabetes mellitus (DM) and hypertension (HTN) is growing worldwide. Both lead to nephropathy if not controlled effectively. Microalbuminuria (MAU) is recognized as an early predictor for nephropathy. Additionally, the timely detection of advanced glyc...
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| Veröffentlicht in: | Indian journal of clinical biochemistry 2018-01, Vol.33 (1), p.81-85 |
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| creator | Gawandi, S. Gangawane, S. Chakrabarti, A. Kedare, S. Bantwal, K. Wadhe, V. Kulkarni, A. Kulkarni, S. Rajan, M. G. R. |
| description | The prevalence of non-communicable diseases like diabetes mellitus (DM) and hypertension (HTN) is growing worldwide. Both lead to nephropathy if not controlled effectively. Microalbuminuria (MAU) is recognized as an early predictor for nephropathy. Additionally, the timely detection of advanced glycation end products (AGEs) is also considered to be an important prognostic factor for diabetic nephropathies. Hence, screening for the early detection of MAU and AGEs would be an useful and relatively inexpensive laboratory test for early clinical diagnosis for the incidence of nephropathy in these diseases. This study was conducted in DM, HTN and pregnancy induced hypertensive (PIH) subjects. MAU and N
ε
-Carboxymethyllysine (CML) levels were estimated by in-house RIA kits in the patient groups and controls, while the total AGEs level in serum was determined by ELISA. The levels of MAU, CML and AGE-BSA were observed to be significantly higher in DM, HTN and PIH subjects compared to controls (
p
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| doi_str_mv | 10.1007/s12291-017-0638-5 |
| format | Article |
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ε
-Carboxymethyllysine (CML) levels were estimated by in-house RIA kits in the patient groups and controls, while the total AGEs level in serum was determined by ELISA. The levels of MAU, CML and AGE-BSA were observed to be significantly higher in DM, HTN and PIH subjects compared to controls (
p
< 0.001). Increased serum CML and AGEs levels in DM, HTN and PIH subjects indicated ongoing glycemic damage and their susceptibility to develop renal complications.</description><identifier>ISSN: 0970-1915</identifier><identifier>EISSN: 0974-0422</identifier><identifier>DOI: 10.1007/s12291-017-0638-5</identifier><identifier>PMID: 29371774</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Advanced glycosylation end products ; Biochemistry ; Biomedical and Life Sciences ; Chemistry/Food Science ; Diabetes ; Diabetes mellitus ; Diabetic nephropathy ; Enzyme-linked immunosorbent assay ; Glycosylation ; Hypertension ; Kidneys ; Life Sciences ; Microbiology ; Nephropathy ; Original ; Original Article ; Pathology ; Pregnancy complications</subject><ispartof>Indian journal of clinical biochemistry, 2018-01, Vol.33 (1), p.81-85</ispartof><rights>Association of Clinical Biochemists of India 2017</rights><rights>Indian Journal of Clinical Biochemistry is a copyright of Springer, (2017). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-c9ff6e220bfe982b3f81839057f01febef255318d0da8324756afd7618287acb3</citedby><cites>FETCH-LOGICAL-c470t-c9ff6e220bfe982b3f81839057f01febef255318d0da8324756afd7618287acb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766458/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5766458/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,41488,42557,51319,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29371774$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gawandi, S.</creatorcontrib><creatorcontrib>Gangawane, S.</creatorcontrib><creatorcontrib>Chakrabarti, A.</creatorcontrib><creatorcontrib>Kedare, S.</creatorcontrib><creatorcontrib>Bantwal, K.</creatorcontrib><creatorcontrib>Wadhe, V.</creatorcontrib><creatorcontrib>Kulkarni, A.</creatorcontrib><creatorcontrib>Kulkarni, S.</creatorcontrib><creatorcontrib>Rajan, M. G. R.</creatorcontrib><title>A Study of Microalbuminuria (MAU) and Advanced Glycation End Products (AGEs) Levels in Diabetic and Hypertensive Subjects</title><title>Indian journal of clinical biochemistry</title><addtitle>Ind J Clin Biochem</addtitle><addtitle>Indian J Clin Biochem</addtitle><description>The prevalence of non-communicable diseases like diabetes mellitus (DM) and hypertension (HTN) is growing worldwide. Both lead to nephropathy if not controlled effectively. Microalbuminuria (MAU) is recognized as an early predictor for nephropathy. Additionally, the timely detection of advanced glycation end products (AGEs) is also considered to be an important prognostic factor for diabetic nephropathies. Hence, screening for the early detection of MAU and AGEs would be an useful and relatively inexpensive laboratory test for early clinical diagnosis for the incidence of nephropathy in these diseases. This study was conducted in DM, HTN and pregnancy induced hypertensive (PIH) subjects. MAU and N
ε
-Carboxymethyllysine (CML) levels were estimated by in-house RIA kits in the patient groups and controls, while the total AGEs level in serum was determined by ELISA. The levels of MAU, CML and AGE-BSA were observed to be significantly higher in DM, HTN and PIH subjects compared to controls (
p
< 0.001). Increased serum CML and AGEs levels in DM, HTN and PIH subjects indicated ongoing glycemic damage and their susceptibility to develop renal complications.</description><subject>Advanced glycosylation end products</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Chemistry/Food Science</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetic nephropathy</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Glycosylation</subject><subject>Hypertension</subject><subject>Kidneys</subject><subject>Life Sciences</subject><subject>Microbiology</subject><subject>Nephropathy</subject><subject>Original</subject><subject>Original Article</subject><subject>Pathology</subject><subject>Pregnancy complications</subject><issn>0970-1915</issn><issn>0974-0422</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kUFv1DAQhSMEoqXwA7ggS1y2h8DYcWL7ghSVZYu0FUilZ8tJxsWrrLPYyUr597i7bdUicbLl-d6bGb8se0_hEwUQnyNlTNEcqMihKmRevshOQQmeA2fs5eEOOVW0PMnexLgBKDhw-jo7YaoQVAh-ms01uR6nbiaDJVeuDYPpm2nr_BScIYur-uacGN-Rutsb32JHVv3cmtENnizT888wdFM7RrKoV8t4Tta4xz4S58lXZxocXXtQX847DCP66PZIrqdmg0nzNntlTR_x3f15lt18W_66uMzXP1bfL-p13nIBY94qaytkDBqLSrKmsJLKQkEpLFCLDVpWlgWVHXRGFoyLsjK2ExWVTArTNsVZ9uXou5uaLXYt-jGYXu-C25ow68E4_bzi3W99O-x1KaqKlzIZLO4NwvBnwjjqrYst9r3xOExRU6UYgKw4JPTjP-hmmIJP6x0ooXhVqETRI5W-O8aA9nEYCvouWH0MVqdg9V2wukyaD0-3eFQ8JJkAdgRiKvlbDE9a_9f1L-g6rfc</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Gawandi, S.</creator><creator>Gangawane, S.</creator><creator>Chakrabarti, A.</creator><creator>Kedare, S.</creator><creator>Bantwal, K.</creator><creator>Wadhe, V.</creator><creator>Kulkarni, A.</creator><creator>Kulkarni, S.</creator><creator>Rajan, M. G. R.</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>04Q</scope><scope>04W</scope><scope>3V.</scope><scope>7XB</scope><scope>88A</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180101</creationdate><title>A Study of Microalbuminuria (MAU) and Advanced Glycation End Products (AGEs) Levels in Diabetic and Hypertensive Subjects</title><author>Gawandi, S. ; Gangawane, S. ; Chakrabarti, A. ; Kedare, S. ; Bantwal, K. ; Wadhe, V. ; Kulkarni, A. ; Kulkarni, S. ; Rajan, M. G. R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-c9ff6e220bfe982b3f81839057f01febef255318d0da8324756afd7618287acb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Advanced glycosylation end products</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Chemistry/Food Science</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetic nephropathy</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Glycosylation</topic><topic>Hypertension</topic><topic>Kidneys</topic><topic>Life Sciences</topic><topic>Microbiology</topic><topic>Nephropathy</topic><topic>Original</topic><topic>Original Article</topic><topic>Pathology</topic><topic>Pregnancy complications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gawandi, S.</creatorcontrib><creatorcontrib>Gangawane, S.</creatorcontrib><creatorcontrib>Chakrabarti, A.</creatorcontrib><creatorcontrib>Kedare, S.</creatorcontrib><creatorcontrib>Bantwal, K.</creatorcontrib><creatorcontrib>Wadhe, V.</creatorcontrib><creatorcontrib>Kulkarni, A.</creatorcontrib><creatorcontrib>Kulkarni, S.</creatorcontrib><creatorcontrib>Rajan, M. 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R.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>India Database</collection><collection>India Database: Science & Technology</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Indian journal of clinical biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gawandi, S.</au><au>Gangawane, S.</au><au>Chakrabarti, A.</au><au>Kedare, S.</au><au>Bantwal, K.</au><au>Wadhe, V.</au><au>Kulkarni, A.</au><au>Kulkarni, S.</au><au>Rajan, M. G. R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Study of Microalbuminuria (MAU) and Advanced Glycation End Products (AGEs) Levels in Diabetic and Hypertensive Subjects</atitle><jtitle>Indian journal of clinical biochemistry</jtitle><stitle>Ind J Clin Biochem</stitle><addtitle>Indian J Clin Biochem</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>33</volume><issue>1</issue><spage>81</spage><epage>85</epage><pages>81-85</pages><issn>0970-1915</issn><eissn>0974-0422</eissn><abstract>The prevalence of non-communicable diseases like diabetes mellitus (DM) and hypertension (HTN) is growing worldwide. Both lead to nephropathy if not controlled effectively. Microalbuminuria (MAU) is recognized as an early predictor for nephropathy. Additionally, the timely detection of advanced glycation end products (AGEs) is also considered to be an important prognostic factor for diabetic nephropathies. Hence, screening for the early detection of MAU and AGEs would be an useful and relatively inexpensive laboratory test for early clinical diagnosis for the incidence of nephropathy in these diseases. This study was conducted in DM, HTN and pregnancy induced hypertensive (PIH) subjects. MAU and N
ε
-Carboxymethyllysine (CML) levels were estimated by in-house RIA kits in the patient groups and controls, while the total AGEs level in serum was determined by ELISA. The levels of MAU, CML and AGE-BSA were observed to be significantly higher in DM, HTN and PIH subjects compared to controls (
p
< 0.001). Increased serum CML and AGEs levels in DM, HTN and PIH subjects indicated ongoing glycemic damage and their susceptibility to develop renal complications.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>29371774</pmid><doi>10.1007/s12291-017-0638-5</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Advanced glycosylation end products Biochemistry Biomedical and Life Sciences Chemistry/Food Science Diabetes Diabetes mellitus Diabetic nephropathy Enzyme-linked immunosorbent assay Glycosylation Hypertension Kidneys Life Sciences Microbiology Nephropathy Original Original Article Pathology Pregnancy complications |
| title | A Study of Microalbuminuria (MAU) and Advanced Glycation End Products (AGEs) Levels in Diabetic and Hypertensive Subjects |
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