An update on vinpocetine: New discoveries and clinical implications
Vinpocetine, a derivative of the alkaloid vincamine, has been clinically used in many countries for treatment of cerebrovascular disorders such as stroke and dementia for more than 30 years. Currently, vinpocetine is also available in the market as a dietary supplement to enhance cognition and memor...
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| Veröffentlicht in: | European journal of pharmacology 2018-01, Vol.819, p.30-34 |
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| container_title | European journal of pharmacology |
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| creator | Zhang, Yi-shuai Li, Jian-dong Yan, Chen |
| description | Vinpocetine, a derivative of the alkaloid vincamine, has been clinically used in many countries for treatment of cerebrovascular disorders such as stroke and dementia for more than 30 years. Currently, vinpocetine is also available in the market as a dietary supplement to enhance cognition and memory. Due to its excellent safety profile, increasing efforts have been put into exploring the novel therapeutic effects and mechanism of actions of vinpocetine in various cell types and disease models. Recent studies have revealed a number of novel functions of vinpocetine, including anti-inflammation, antagonizing injury-induced vascular remodeling and high-fat-diet-induced atherosclerosis, as well as attenuating pathological cardiac remodeling. These novel findings may facilitate the repositioning of vinpocetine for preventing or treating relevant disorders in humans. |
| doi_str_mv | 10.1016/j.ejphar.2017.11.041 |
| format | Article |
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These novel findings may facilitate the repositioning of vinpocetine for preventing or treating relevant disorders in humans.</description><subject>Animals</subject><subject>Cardiovascular</subject><subject>Heart Diseases - drug therapy</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Nervous System Diseases - drug therapy</subject><subject>Neurovascular</subject><subject>Vascular Diseases - drug therapy</subject><subject>Vinca Alkaloids - pharmacology</subject><subject>Vinca Alkaloids - therapeutic use</subject><subject>Vinpocetine</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9v1DAQxS0EokvhG1QoRy4JM4ntxD1Uqlblj1TBBc6WdzLbepW1Uzu7Fd--WbaUcuE0I83Me29-QpwhVAioP24q3oy3LlU1YFshViDxhVhg15oSWqxfigUAyrI2xpyINzlvAECZWr0WJ7XBrukavRDLy1Dsxt5NXMRQ7H0YI_HkA58X3_i-6H2muOfkORcu9AUNPnhyQ-G34zA3k48hvxWv1m7I_O6xnoqfn65-LL-U198_f11eXpckdTOVjXJr3SvdARoAaWCljFaksVs7rRx1JPtaEek5GitJUuEKWJPWHWopTXMqLo6642615Z44TMkNdkx-69IvG523_06Cv7U3cW9Vq3XTHQQ-PAqkeLfjPNnt_B8Pgwscd9miaaFusfntJY-rlGLOiddPNgj2wN9u7JG_PfC3iHbmP5-9fx7x6egP8L8_8Axq7znZTJ4Dce8T02T76P_v8ABibpiu</recordid><startdate>20180115</startdate><enddate>20180115</enddate><creator>Zhang, Yi-shuai</creator><creator>Li, Jian-dong</creator><creator>Yan, Chen</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180115</creationdate><title>An update on vinpocetine: New discoveries and clinical implications</title><author>Zhang, Yi-shuai ; Li, Jian-dong ; Yan, Chen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-35af6d56801900490b5965c618fa65ac8c4d25cc6838e54c451b0e6c668164493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>Cardiovascular</topic><topic>Heart Diseases - drug therapy</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Nervous System Diseases - drug therapy</topic><topic>Neurovascular</topic><topic>Vascular Diseases - drug therapy</topic><topic>Vinca Alkaloids - pharmacology</topic><topic>Vinca Alkaloids - therapeutic use</topic><topic>Vinpocetine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Yi-shuai</creatorcontrib><creatorcontrib>Li, Jian-dong</creatorcontrib><creatorcontrib>Yan, Chen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Yi-shuai</au><au>Li, Jian-dong</au><au>Yan, Chen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>An update on vinpocetine: New discoveries and clinical implications</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>2018-01-15</date><risdate>2018</risdate><volume>819</volume><spage>30</spage><epage>34</epage><pages>30-34</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>Vinpocetine, a derivative of the alkaloid vincamine, has been clinically used in many countries for treatment of cerebrovascular disorders such as stroke and dementia for more than 30 years. 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| ispartof | European journal of pharmacology, 2018-01, Vol.819, p.30-34 |
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| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5766389 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Cardiovascular Heart Diseases - drug therapy Humans Inflammation Nervous System Diseases - drug therapy Neurovascular Vascular Diseases - drug therapy Vinca Alkaloids - pharmacology Vinca Alkaloids - therapeutic use Vinpocetine |
| title | An update on vinpocetine: New discoveries and clinical implications |
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