A novel non-canonical PIP-box mediates PARG interaction with PCNA

Poly(ADP-ribose) glycohydrolase (PARG) regulates cellular poly(ADP-ribose) (PAR) levels by rapidly cleaving glycosidic bonds between ADP-ribose units. PARG interacts with proliferating cell nuclear antigen (PCNA) and is strongly recruited to DNA damage sites in a PAR- and PCNA-dependent fashion. Her...

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Veröffentlicht in:	Nucleic acids research 2017-09, Vol.45 (16), p.9741-9759
Hauptverfasser:	Kaufmann, Tanja, Grishkovskaya, Irina, Polyansky, Anton A, Kostrhon, Sebastian, Kukolj, Eva, Olek, Karin M, Herbert, Sebastien, Beltzung, Etienne, Mechtler, Karl, Peterbauer, Thomas, Gotzmann, Josef, Zhang, Lijuan, Hartl, Markus, Zagrovic, Bojan, Elsayad, Kareem, Djinovic-Carugo, Kristina, Slade, Dea
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Calorimetry - methods Chromatin - metabolism Crystallography, X-Ray DNA Damage Fluorescence Resonance Energy Transfer Glycoside Hydrolases - chemistry Glycoside Hydrolases - genetics Glycoside Hydrolases - metabolism HeLa Cells Humans Immunoprecipitation Lasers Lysine - genetics Lysine - metabolism Molecular Dynamics Simulation Proliferating Cell Nuclear Antigen - chemistry Proliferating Cell Nuclear Antigen - metabolism Protein Conformation S Phase - genetics Static Electricity Structural Biology
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