Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer

Metastatic colorectal cancers (mCRCs) are clinically heterogeneous, but the genomic basis of this variability remains poorly understood. We performed prospective targeted sequencing of 1,134 CRCs. We identified splice alterations in intronic regions of APC and large in-frame deletions in CTNNB1, inc...

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Veröffentlicht in:	Cancer cell 2018-01, Vol.33 (1), p.125-136.e3
Hauptverfasser:	Yaeger, Rona, Chatila, Walid K., Lipsyc, Marla D., Hechtman, Jaclyn F., Cercek, Andrea, Sanchez-Vega, Francisco, Jayakumaran, Gowtham, Middha, Sumit, Zehir, Ahmet, Donoghue, Mark T.A., You, Daoqi, Viale, Agnes, Kemeny, Nancy, Segal, Neil H., Stadler, Zsofia K., Varghese, Anna M., Kundra, Ritika, Gao, Jianjiong, Syed, Aijazuddin, Hyman, David M., Vakiani, Efsevia, Rosen, Neal, Taylor, Barry S., Ladanyi, Marc, Berger, Michael F., Solit, David B., Shia, Jinru, Saltz, Leonard, Schultz, Nikolaus
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged APC Carcinogenesis - genetics Colonic Neoplasms - genetics colorectal cancer Colorectal Neoplasms - genetics CTNNB1 Female Genomics Humans integrative genomics analysis intronic alterations location Male Microsatellite Instability Middle Aged Mutation - genetics Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism prognosis Proto-Oncogene Proteins B-raf - genetics
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