Ethical and Safety Issues of Stem Cell-Based Therapy
Results obtained from completed and on-going clinical studies indicate huge therapeutic potential of stem cell-based therapy in the treatment of degenerative, autoimmune and genetic disorders. However, clinical application of stem cells raises numerous ethical and safety concerns. In this review, we...
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| Veröffentlicht in: | International journal of medical sciences 2018, Vol.15 (1), p.36-45 |
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| creator | Volarevic, Vladislav Markovic, Bojana Simovic Gazdic, Marina Volarevic, Ana Jovicic, Nemanja Arsenijevic, Nebojsa Armstrong, Lyle Djonov, Valentin Lako, Majlinda Stojkovic, Miodrag |
| description | Results obtained from completed and on-going clinical studies indicate huge therapeutic potential of stem cell-based therapy in the treatment of degenerative, autoimmune and genetic disorders. However, clinical application of stem cells raises numerous ethical and safety concerns. In this review, we provide an overview of the most important ethical issues in stem cell therapy, as a contribution to the controversial debate about their clinical usage in regenerative and transplantation medicine. We describe ethical challenges regarding human embryonic stem cell (hESC) research, emphasizing that ethical dilemma involving the destruction of a human embryo is a major factor that may have limited the development of hESC-based clinical therapies. With previous derivation of induced pluripotent stem cells (iPSCs) this problem has been overcome, however current perspectives regarding clinical translation of iPSCs still remain. Unlimited differentiation potential of iPSCs which can be used in human reproductive cloning, as a risk for generation of genetically engineered human embryos and human-animal chimeras, is major ethical issue, while undesired differentiation and malignant transformation are major safety issues. Although clinical application of mesenchymal stem cells (MSCs) has shown beneficial effects in the therapy of autoimmune and chronic inflammatory diseases, the ability to promote tumor growth and metastasis and overestimated therapeutic potential of MSCs still provide concerns for the field of regenerative medicine. This review offers stem cell scientists, clinicians and patient's useful information and could be used as a starting point for more in-depth analysis of ethical and safety issues related to clinical application of stem cells. |
| doi_str_mv | 10.7150/ijms.21666 |
| format | Article |
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However, clinical application of stem cells raises numerous ethical and safety concerns. In this review, we provide an overview of the most important ethical issues in stem cell therapy, as a contribution to the controversial debate about their clinical usage in regenerative and transplantation medicine. We describe ethical challenges regarding human embryonic stem cell (hESC) research, emphasizing that ethical dilemma involving the destruction of a human embryo is a major factor that may have limited the development of hESC-based clinical therapies. With previous derivation of induced pluripotent stem cells (iPSCs) this problem has been overcome, however current perspectives regarding clinical translation of iPSCs still remain. Unlimited differentiation potential of iPSCs which can be used in human reproductive cloning, as a risk for generation of genetically engineered human embryos and human-animal chimeras, is major ethical issue, while undesired differentiation and malignant transformation are major safety issues. Although clinical application of mesenchymal stem cells (MSCs) has shown beneficial effects in the therapy of autoimmune and chronic inflammatory diseases, the ability to promote tumor growth and metastasis and overestimated therapeutic potential of MSCs still provide concerns for the field of regenerative medicine. 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However, clinical application of stem cells raises numerous ethical and safety concerns. In this review, we provide an overview of the most important ethical issues in stem cell therapy, as a contribution to the controversial debate about their clinical usage in regenerative and transplantation medicine. We describe ethical challenges regarding human embryonic stem cell (hESC) research, emphasizing that ethical dilemma involving the destruction of a human embryo is a major factor that may have limited the development of hESC-based clinical therapies. With previous derivation of induced pluripotent stem cells (iPSCs) this problem has been overcome, however current perspectives regarding clinical translation of iPSCs still remain. Unlimited differentiation potential of iPSCs which can be used in human reproductive cloning, as a risk for generation of genetically engineered human embryos and human-animal chimeras, is major ethical issue, while undesired differentiation and malignant transformation are major safety issues. Although clinical application of mesenchymal stem cells (MSCs) has shown beneficial effects in the therapy of autoimmune and chronic inflammatory diseases, the ability to promote tumor growth and metastasis and overestimated therapeutic potential of MSCs still provide concerns for the field of regenerative medicine. This review offers stem cell scientists, clinicians and patient's useful information and could be used as a starting point for more in-depth analysis of ethical and safety issues related to clinical application of stem cells.</description><subject>Animals</subject><subject>Biomedical Research - ethics</subject><subject>Biomedical Research - methods</subject><subject>Cell Culture Techniques - ethics</subject><subject>Cell Culture Techniques - methods</subject><subject>Cell Differentiation - genetics</subject><subject>Cell Transplantation - ethics</subject><subject>Cell Transplantation - methods</subject><subject>Chimera - genetics</subject><subject>Embryo, Mammalian - cytology</subject><subject>Genetic Engineering - adverse effects</subject><subject>Genetic Engineering - ethics</subject><subject>Genetic Engineering - methods</subject><subject>Genetic Therapy - adverse effects</subject><subject>Genetic Therapy - ethics</subject><subject>Genetic Therapy - methods</subject><subject>Human Embryonic Stem Cells - transplantation</subject><subject>Humans</subject><subject>Induced Pluripotent Stem Cells - transplantation</subject><subject>Mesenchymal Stem Cell Transplantation - adverse effects</subject><subject>Mesenchymal Stem Cell Transplantation - ethics</subject><subject>Regenerative Medicine - ethics</subject><subject>Regenerative Medicine - methods</subject><subject>Review</subject><issn>1449-1907</issn><issn>1449-1907</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkE1Lw0AQhhdRbK1e_AGSowips9mv7EXQUrVQ8NB6XibJrk3JR82mhf57U1tLPc3APLwz8xByS2GoqIDHfFn6YUSllGekTznXIdWgzk_6HrnyfgnAIqboJelFmjEGsewTPm4XeYpFgFUWzNDZdhtMvF9bH9QumLW2DEa2KMIX9DYL5gvb4Gp7TS4cFt7eHOqAfL6O56P3cPrxNhk9T8OUx6INOTAAl0ZZoqnKAKwViaTouBIYuVhzjpBlCaJGpcFqKWiSSLCOJsgRJRuQp33uap2UNktt1TZYmFWTl9hsTY25-T-p8oX5qjdGKCkUi7uA-0NAU393P7WmzH3a_YOVrdfeUB1rEfMdPCAPezRtau8b645rKJidZrPTbH41d_Dd6WFH9M8r-wF0KXj1</recordid><startdate>2018</startdate><enddate>2018</enddate><creator>Volarevic, Vladislav</creator><creator>Markovic, Bojana Simovic</creator><creator>Gazdic, Marina</creator><creator>Volarevic, Ana</creator><creator>Jovicic, Nemanja</creator><creator>Arsenijevic, Nebojsa</creator><creator>Armstrong, Lyle</creator><creator>Djonov, Valentin</creator><creator>Lako, Majlinda</creator><creator>Stojkovic, Miodrag</creator><general>Ivyspring International Publisher</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>2018</creationdate><title>Ethical and Safety Issues of Stem Cell-Based Therapy</title><author>Volarevic, Vladislav ; 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| subjects | Animals Biomedical Research - ethics Biomedical Research - methods Cell Culture Techniques - ethics Cell Culture Techniques - methods Cell Differentiation - genetics Cell Transplantation - ethics Cell Transplantation - methods Chimera - genetics Embryo, Mammalian - cytology Genetic Engineering - adverse effects Genetic Engineering - ethics Genetic Engineering - methods Genetic Therapy - adverse effects Genetic Therapy - ethics Genetic Therapy - methods Human Embryonic Stem Cells - transplantation Humans Induced Pluripotent Stem Cells - transplantation Mesenchymal Stem Cell Transplantation - adverse effects Mesenchymal Stem Cell Transplantation - ethics Regenerative Medicine - ethics Regenerative Medicine - methods Review |
| title | Ethical and Safety Issues of Stem Cell-Based Therapy |
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