Mechanistic Model‐Informed Proarrhythmic Risk Assessment of Drugs: Review of the “CiPA” Initiative and Design of a Prospective Clinical Validation Study

The Comprehensive in vitro Proarrhythmia Assay (CiPA) initiative is developing and validating a mechanistic‐based assessment of the proarrhythmic risk of drugs. CiPA proposes to assess a drug's effect on multiple ion channels and integrate the effects in a computer model of the human cardiomyoc...

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Veröffentlicht in:	Clinical pharmacology and therapeutics 2018-01, Vol.103 (1), p.54-66
Hauptverfasser:	Vicente, Jose, Zusterzeel, Robbert, Johannesen, Lars, Mason, Jay, Sager, Philip, Patel, Vikram, Matta, Murali K., Li, Zhihua, Liu, Jiang, Garnett, Christine, Stockbridge, Norman, Zineh, Issam, Strauss, David G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Arrhythmias, Cardiac - chemically induced Arrhythmias, Cardiac - diagnosis Arrhythmias, Cardiac - prevention & control Clinical Studies as Topic - methods Clinical Studies as Topic - standards Computer Simulation Drug Evaluation, Preclinical - methods Drug Evaluation, Preclinical - standards Electrocardiography - methods Humans Risk Assessment - methods State of the Art Validation Studies as Topic
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