Issues with the Specificity of Immunological Reagents for NLRP3: Implications for Age-related Macular Degeneration

Contradictory data have been presented regarding the implication of the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome in age-related macular degeneration (AMD), the leading cause of vision loss in the Western world. Recognizing that antibody specificity may explain this discre...

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Veröffentlicht in:	Scientific reports 2018-01, Vol.8 (1), p.461-461, Article 461
Hauptverfasser:	Kosmidou, Cassandra, Efstathiou, Nikolaos E., Hoang, Mien V., Notomi, Shoji, Konstantinou, Eleni K., Hirano, Masayuki, Takahashi, Kosuke, Maidana, Daniel E., Tsoka, Pavlina, Young, Lucy, Gragoudas, Evangelos S., Olsen, Timothy W., Morizane, Yuki, Miller, Joan W., Vavvas, Demetrios G.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/109 38/77 631/250 64/60 692/4017 82/29 82/80 Age Alu Elements Animals Antibodies - analysis Antibody Specificity Cell Line Cell lines Clonal deletion Cryopyrin DEAD-box RNA Helicases - genetics Detection limits Disease Models, Animal Gene Deletion Humanities and Social Sciences Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Inflammasomes Macular degeneration Macular Degeneration - genetics Macular Degeneration - immunology Mice multidisciplinary NLR Family, Pyrin Domain-Containing 3 Protein - immunology Pluripotency Reagents Retinal Pigment Epithelium - cytology Retinal Pigment Epithelium - metabolism Ribonuclease III - genetics Ribonucleic acid RNA Science Science (multidisciplinary) Stem cells THP-1 Cells Transfection
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