Task-related changes in degree centrality and local coherence of the posterior cingulate cortex after major cardiac surgery in older adults
Older adults often display postoperative cognitive decline (POCD) after surgery, yet it is unclear to what extent functional connectivity (FC) alterations may underlie these deficits. We examined for postoperative voxel-wise FC changes in response to increased working memory load demands in cardiac...
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| creator | Browndyke, Jeffrey N Berger, Miles Smith, Patrick J Harshbarger, Todd B Monge, Zachary A Panchal, Viral Bisanar, Tiffany L Glower, Donald D Alexander, John H Cabeza, Roberto Welsh-Bohmer, Kathleen Newman, Mark F Mathew, Joseph P |
| description | Older adults often display postoperative cognitive decline (POCD) after surgery, yet it is unclear to what extent functional connectivity (FC) alterations may underlie these deficits. We examined for postoperative voxel-wise FC changes in response to increased working memory load demands in cardiac surgery patients and nonsurgical controls.
Older cardiac surgery patients (n = 25) completed a verbal N-back working memory task during MRI scanning and cognitive testing before and 6 weeks after surgery; nonsurgical controls with cardiac disease (n = 26) underwent these assessments at identical time intervals. We measured postoperative changes in degree centrality, the number of edges attached to a brain node, and local coherence, the temporal homogeneity of regional functional correlations, using voxel-wise graph theory-based FC metrics. Group × time differences were evaluated in these FC metrics associated with increased N-back working memory load (2-back > 1-back), using a two-stage partitioned variance, mixed ANCOVA.
Cardiac surgery patients demonstrated postoperative working memory load-related degree centrality increases in the left dorsal posterior cingulate cortex (dPCC; p |
| doi_str_mv | 10.1002/hbm.23898 |
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Older cardiac surgery patients (n = 25) completed a verbal N-back working memory task during MRI scanning and cognitive testing before and 6 weeks after surgery; nonsurgical controls with cardiac disease (n = 26) underwent these assessments at identical time intervals. We measured postoperative changes in degree centrality, the number of edges attached to a brain node, and local coherence, the temporal homogeneity of regional functional correlations, using voxel-wise graph theory-based FC metrics. Group × time differences were evaluated in these FC metrics associated with increased N-back working memory load (2-back > 1-back), using a two-stage partitioned variance, mixed ANCOVA.
Cardiac surgery patients demonstrated postoperative working memory load-related degree centrality increases in the left dorsal posterior cingulate cortex (dPCC; p < .001, cluster p-FWE < .05). The dPCC also showed a postoperative increase in working memory load-associated local coherence (p < .001, cluster p-FWE < .05). dPCC degree centrality and local coherence increases were inversely associated with global cognitive change in surgery patients (p < .01), but not in controls.
Cardiac surgery patients showed postoperative increases in working memory load-associated degree centrality and local coherence of the dPCC that were inversely associated with postoperative global cognitive outcomes and independent of perioperative cerebrovascular damage.</description><identifier>ISSN: 1065-9471</identifier><identifier>ISSN: 1097-0193</identifier><identifier>EISSN: 1097-0193</identifier><identifier>DOI: 10.1002/hbm.23898</identifier><identifier>PMID: 29164774</identifier><language>eng</language><publisher>United States: John Wiley & Sons, Inc</publisher><subject>Adults ; Aged ; Aged, 80 and over ; Brain ; Cardiac Surgical Procedures ; Cerebrovascular system ; Clusters ; Cognitive ability ; Cognitive Dysfunction - diagnostic imaging ; Cognitive Dysfunction - etiology ; Cognitive Dysfunction - physiopathology ; Coherence ; Coronary artery disease ; Cortex (cingulate) ; Cortex (temporal) ; Disease control ; Experimental design ; Female ; Grammar ; Graph theory ; Gyrus Cinguli - diagnostic imaging ; Gyrus Cinguli - physiopathology ; Heart diseases ; Heart surgery ; Homogeneity ; Humans ; Language ; Magnetic resonance imaging ; Male ; Memory ; Memory, Short-Term - physiology ; Mental task performance ; Middle Aged ; Neural networks ; Older people ; Patients ; Postoperative Complications - diagnostic imaging ; Postoperative Complications - physiopathology ; Short term memory ; Surgery</subject><ispartof>Human brain mapping, 2018-02, Vol.39 (2), p.985-1003</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><rights>2018 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-acc9782e6a55ba725384a1831fc2cb81ef09295ee725faab0db5d3aadd3034e3</citedby><cites>FETCH-LOGICAL-c403t-acc9782e6a55ba725384a1831fc2cb81ef09295ee725faab0db5d3aadd3034e3</cites><orcidid>0000-0002-8573-7073</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764802/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764802/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29164774$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Browndyke, Jeffrey N</creatorcontrib><creatorcontrib>Berger, Miles</creatorcontrib><creatorcontrib>Smith, Patrick J</creatorcontrib><creatorcontrib>Harshbarger, Todd B</creatorcontrib><creatorcontrib>Monge, Zachary A</creatorcontrib><creatorcontrib>Panchal, Viral</creatorcontrib><creatorcontrib>Bisanar, Tiffany L</creatorcontrib><creatorcontrib>Glower, Donald D</creatorcontrib><creatorcontrib>Alexander, John H</creatorcontrib><creatorcontrib>Cabeza, Roberto</creatorcontrib><creatorcontrib>Welsh-Bohmer, Kathleen</creatorcontrib><creatorcontrib>Newman, Mark F</creatorcontrib><creatorcontrib>Mathew, Joseph P</creatorcontrib><creatorcontrib>Duke Neurologic Outcomes Research Group (NORG)</creatorcontrib><title>Task-related changes in degree centrality and local coherence of the posterior cingulate cortex after major cardiac surgery in older adults</title><title>Human brain mapping</title><addtitle>Hum Brain Mapp</addtitle><description>Older adults often display postoperative cognitive decline (POCD) after surgery, yet it is unclear to what extent functional connectivity (FC) alterations may underlie these deficits. We examined for postoperative voxel-wise FC changes in response to increased working memory load demands in cardiac surgery patients and nonsurgical controls.
Older cardiac surgery patients (n = 25) completed a verbal N-back working memory task during MRI scanning and cognitive testing before and 6 weeks after surgery; nonsurgical controls with cardiac disease (n = 26) underwent these assessments at identical time intervals. We measured postoperative changes in degree centrality, the number of edges attached to a brain node, and local coherence, the temporal homogeneity of regional functional correlations, using voxel-wise graph theory-based FC metrics. Group × time differences were evaluated in these FC metrics associated with increased N-back working memory load (2-back > 1-back), using a two-stage partitioned variance, mixed ANCOVA.
Cardiac surgery patients demonstrated postoperative working memory load-related degree centrality increases in the left dorsal posterior cingulate cortex (dPCC; p < .001, cluster p-FWE < .05). The dPCC also showed a postoperative increase in working memory load-associated local coherence (p < .001, cluster p-FWE < .05). dPCC degree centrality and local coherence increases were inversely associated with global cognitive change in surgery patients (p < .01), but not in controls.
Cardiac surgery patients showed postoperative increases in working memory load-associated degree centrality and local coherence of the dPCC that were inversely associated with postoperative global cognitive outcomes and independent of perioperative cerebrovascular damage.</description><subject>Adults</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Brain</subject><subject>Cardiac Surgical Procedures</subject><subject>Cerebrovascular system</subject><subject>Clusters</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - diagnostic imaging</subject><subject>Cognitive Dysfunction - etiology</subject><subject>Cognitive Dysfunction - physiopathology</subject><subject>Coherence</subject><subject>Coronary artery disease</subject><subject>Cortex (cingulate)</subject><subject>Cortex (temporal)</subject><subject>Disease control</subject><subject>Experimental design</subject><subject>Female</subject><subject>Grammar</subject><subject>Graph theory</subject><subject>Gyrus Cinguli - diagnostic imaging</subject><subject>Gyrus Cinguli - physiopathology</subject><subject>Heart diseases</subject><subject>Heart surgery</subject><subject>Homogeneity</subject><subject>Humans</subject><subject>Language</subject><subject>Magnetic resonance imaging</subject><subject>Male</subject><subject>Memory</subject><subject>Memory, Short-Term - physiology</subject><subject>Mental task performance</subject><subject>Middle Aged</subject><subject>Neural networks</subject><subject>Older people</subject><subject>Patients</subject><subject>Postoperative Complications - diagnostic imaging</subject><subject>Postoperative Complications - physiopathology</subject><subject>Short term memory</subject><subject>Surgery</subject><issn>1065-9471</issn><issn>1097-0193</issn><issn>1097-0193</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkctuFDEQRVsIREJgwQ8gS2xg0Ykf_fIGCUU8IkXKZvZWtV39GNz2YLsR8w38NG4yRJCVSzpH11W6RfGa0UtGKb-a-uWSi052T4pzRmVbUibF021u6lJWLTsrXsS4p5SxmrLnxRmXrKnatjovfu0gfisDWkhoiJ7AjRjJ7IjBMSASjS4FsHM6EnCGWK_BEu0nDOg0Ej-QNCE5-JgwzD4QPbtx3cKyFBL-JDBkQhbYbxCCmUGTuIYRw3H7xluTMZjVpviyeDaAjfjq9F4Uu8-fdtdfy9u7LzfXH29LXVGRStBath3HBuq6h5bXoquAdYINmuu-YzhQyWWNmNEA0FPT10YAGCOoqFBcFB_uYw9rv6A5XagOYV4gHJWHWf1P3Dyp0f9QddtUHeU54N0pIPjvK8akljlqtBYc-jUqJpu2alrKZVbfPlL3fg0uX5etrqk4bdhmvb-3dPAxBhwelmFUbQ2r3LD603B23_y7_YP5t1LxGzfhpUM</recordid><startdate>20180201</startdate><enddate>20180201</enddate><creator>Browndyke, Jeffrey N</creator><creator>Berger, Miles</creator><creator>Smith, Patrick J</creator><creator>Harshbarger, Todd B</creator><creator>Monge, Zachary A</creator><creator>Panchal, Viral</creator><creator>Bisanar, Tiffany L</creator><creator>Glower, Donald D</creator><creator>Alexander, John H</creator><creator>Cabeza, Roberto</creator><creator>Welsh-Bohmer, Kathleen</creator><creator>Newman, Mark F</creator><creator>Mathew, Joseph P</creator><general>John Wiley & Sons, Inc</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8573-7073</orcidid></search><sort><creationdate>20180201</creationdate><title>Task-related changes in degree centrality and local coherence of the posterior cingulate cortex after major cardiac surgery in older adults</title><author>Browndyke, Jeffrey N ; Berger, Miles ; Smith, Patrick J ; Harshbarger, Todd B ; Monge, Zachary A ; Panchal, Viral ; Bisanar, Tiffany L ; Glower, Donald D ; Alexander, John H ; Cabeza, Roberto ; Welsh-Bohmer, Kathleen ; Newman, Mark F ; Mathew, Joseph P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-acc9782e6a55ba725384a1831fc2cb81ef09295ee725faab0db5d3aadd3034e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Adults</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Brain</topic><topic>Cardiac Surgical Procedures</topic><topic>Cerebrovascular system</topic><topic>Clusters</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - diagnostic imaging</topic><topic>Cognitive Dysfunction - etiology</topic><topic>Cognitive Dysfunction - physiopathology</topic><topic>Coherence</topic><topic>Coronary artery disease</topic><topic>Cortex (cingulate)</topic><topic>Cortex (temporal)</topic><topic>Disease control</topic><topic>Experimental design</topic><topic>Female</topic><topic>Grammar</topic><topic>Graph theory</topic><topic>Gyrus Cinguli - diagnostic imaging</topic><topic>Gyrus Cinguli - physiopathology</topic><topic>Heart diseases</topic><topic>Heart surgery</topic><topic>Homogeneity</topic><topic>Humans</topic><topic>Language</topic><topic>Magnetic resonance imaging</topic><topic>Male</topic><topic>Memory</topic><topic>Memory, Short-Term - physiology</topic><topic>Mental task performance</topic><topic>Middle Aged</topic><topic>Neural networks</topic><topic>Older people</topic><topic>Patients</topic><topic>Postoperative Complications - diagnostic imaging</topic><topic>Postoperative Complications - physiopathology</topic><topic>Short term memory</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Browndyke, Jeffrey N</creatorcontrib><creatorcontrib>Berger, Miles</creatorcontrib><creatorcontrib>Smith, Patrick J</creatorcontrib><creatorcontrib>Harshbarger, Todd B</creatorcontrib><creatorcontrib>Monge, Zachary A</creatorcontrib><creatorcontrib>Panchal, Viral</creatorcontrib><creatorcontrib>Bisanar, Tiffany L</creatorcontrib><creatorcontrib>Glower, Donald D</creatorcontrib><creatorcontrib>Alexander, John H</creatorcontrib><creatorcontrib>Cabeza, Roberto</creatorcontrib><creatorcontrib>Welsh-Bohmer, Kathleen</creatorcontrib><creatorcontrib>Newman, Mark F</creatorcontrib><creatorcontrib>Mathew, Joseph P</creatorcontrib><creatorcontrib>Duke Neurologic Outcomes Research Group (NORG)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Human brain mapping</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Browndyke, Jeffrey N</au><au>Berger, Miles</au><au>Smith, Patrick J</au><au>Harshbarger, Todd B</au><au>Monge, Zachary A</au><au>Panchal, Viral</au><au>Bisanar, Tiffany L</au><au>Glower, Donald D</au><au>Alexander, John H</au><au>Cabeza, Roberto</au><au>Welsh-Bohmer, Kathleen</au><au>Newman, Mark F</au><au>Mathew, Joseph P</au><aucorp>Duke Neurologic Outcomes Research Group (NORG)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Task-related changes in degree centrality and local coherence of the posterior cingulate cortex after major cardiac surgery in older adults</atitle><jtitle>Human brain mapping</jtitle><addtitle>Hum Brain Mapp</addtitle><date>2018-02-01</date><risdate>2018</risdate><volume>39</volume><issue>2</issue><spage>985</spage><epage>1003</epage><pages>985-1003</pages><issn>1065-9471</issn><issn>1097-0193</issn><eissn>1097-0193</eissn><abstract>Older adults often display postoperative cognitive decline (POCD) after surgery, yet it is unclear to what extent functional connectivity (FC) alterations may underlie these deficits. We examined for postoperative voxel-wise FC changes in response to increased working memory load demands in cardiac surgery patients and nonsurgical controls.
Older cardiac surgery patients (n = 25) completed a verbal N-back working memory task during MRI scanning and cognitive testing before and 6 weeks after surgery; nonsurgical controls with cardiac disease (n = 26) underwent these assessments at identical time intervals. We measured postoperative changes in degree centrality, the number of edges attached to a brain node, and local coherence, the temporal homogeneity of regional functional correlations, using voxel-wise graph theory-based FC metrics. Group × time differences were evaluated in these FC metrics associated with increased N-back working memory load (2-back > 1-back), using a two-stage partitioned variance, mixed ANCOVA.
Cardiac surgery patients demonstrated postoperative working memory load-related degree centrality increases in the left dorsal posterior cingulate cortex (dPCC; p < .001, cluster p-FWE < .05). The dPCC also showed a postoperative increase in working memory load-associated local coherence (p < .001, cluster p-FWE < .05). dPCC degree centrality and local coherence increases were inversely associated with global cognitive change in surgery patients (p < .01), but not in controls.
Cardiac surgery patients showed postoperative increases in working memory load-associated degree centrality and local coherence of the dPCC that were inversely associated with postoperative global cognitive outcomes and independent of perioperative cerebrovascular damage.</abstract><cop>United States</cop><pub>John Wiley & Sons, Inc</pub><pmid>29164774</pmid><doi>10.1002/hbm.23898</doi><tpages>19</tpages><orcidid>https://orcid.org/0000-0002-8573-7073</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Adults Aged Aged, 80 and over Brain Cardiac Surgical Procedures Cerebrovascular system Clusters Cognitive ability Cognitive Dysfunction - diagnostic imaging Cognitive Dysfunction - etiology Cognitive Dysfunction - physiopathology Coherence Coronary artery disease Cortex (cingulate) Cortex (temporal) Disease control Experimental design Female Grammar Graph theory Gyrus Cinguli - diagnostic imaging Gyrus Cinguli - physiopathology Heart diseases Heart surgery Homogeneity Humans Language Magnetic resonance imaging Male Memory Memory, Short-Term - physiology Mental task performance Middle Aged Neural networks Older people Patients Postoperative Complications - diagnostic imaging Postoperative Complications - physiopathology Short term memory Surgery |
| title | Task-related changes in degree centrality and local coherence of the posterior cingulate cortex after major cardiac surgery in older adults |
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