Icariin Regulates the Bidirectional Differentiation of Bone Marrow Mesenchymal Stem Cells through Canonical Wnt Signaling Pathway
Fat infiltration within the bone marrow is easily observed in some postmenopausal women. Those fats are mainly derived from bone marrow mesenchymal stem cells (BMMSCs). The increment of adipocytes derived from BMMSCs leads to decreased osteoblasts derived from BMMSCs, so the bidirectional differenti...
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| creator | Guo, Jin-feng Yao, Xu-dong Guo, Jia-chao Jing, Xing-zhi Xiang, Wei Bao, Yuan Huang, Jun-ming Wang, Rui |
| description | Fat infiltration within the bone marrow is easily observed in some postmenopausal women. Those fats are mainly derived from bone marrow mesenchymal stem cells (BMMSCs). The increment of adipocytes derived from BMMSCs leads to decreased osteoblasts derived from BMMSCs, so the bidirectional differentiation of BMMSCs significantly contributes to osteoporosis. Icariin is the main extractive of Herba Epimedii which is widely used in traditional Chinese medicine. In this experiment, we investigated the effect of icariin on the bidirectional differentiation of BMMSCs through quantitative real-time PCR, immunofluorescence, western blot, and tissue sections in vitro and in vivo. We found that icariin obviously promotes osteogenesis and inhibits adipogenesis through detecting staining and gene expression. Micro-CT analysis showed that icariin treatment alleviated the loss of cancellous bone of the distal femur in ovariectomized (OVX) mice. H&E staining analysis showed that icariin-treated OVX mice obtained higher bone mass and fewer bone marrow lipid droplets than OVX mice. Western blot and immunofluorescence showed that icariin regulates the bidirectional differentiation of BMMSCs via canonical Wnt signaling. This study demonstrates that icariin exerts its antiosteoporotic effect by regulating the bidirectional differentiation of BMMSCs through the canonical Wnt signaling pathway. |
| doi_str_mv | 10.1155/2017/8085325 |
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Those fats are mainly derived from bone marrow mesenchymal stem cells (BMMSCs). The increment of adipocytes derived from BMMSCs leads to decreased osteoblasts derived from BMMSCs, so the bidirectional differentiation of BMMSCs significantly contributes to osteoporosis. Icariin is the main extractive of Herba Epimedii which is widely used in traditional Chinese medicine. In this experiment, we investigated the effect of icariin on the bidirectional differentiation of BMMSCs through quantitative real-time PCR, immunofluorescence, western blot, and tissue sections in vitro and in vivo. We found that icariin obviously promotes osteogenesis and inhibits adipogenesis through detecting staining and gene expression. Micro-CT analysis showed that icariin treatment alleviated the loss of cancellous bone of the distal femur in ovariectomized (OVX) mice. H&E staining analysis showed that icariin-treated OVX mice obtained higher bone mass and fewer bone marrow lipid droplets than OVX mice. Western blot and immunofluorescence showed that icariin regulates the bidirectional differentiation of BMMSCs via canonical Wnt signaling. This study demonstrates that icariin exerts its antiosteoporotic effect by regulating the bidirectional differentiation of BMMSCs through the canonical Wnt signaling pathway.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2017/8085325</identifier><identifier>PMID: 29445413</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adipocytes ; Adipogenesis ; Bone density ; Bone marrow ; Bone mass ; Bones ; Cancellous bone ; Computed tomography ; Density ; Ethylenediaminetetraacetic acid ; Fats ; Femur ; Gene expression ; Immunofluorescence ; Kinases ; Menopause ; Mesenchymal stem cells ; Mesenchyme ; Mice ; Mutation ; Osteoblastogenesis ; Osteoblasts ; Osteogenesis ; Osteoporosis ; Ovariectomy ; Post-menopause ; Postmenopausal women ; Rodents ; Signal transduction ; Staining ; Stem cell transplantation ; Stem cells ; Traditional Chinese medicine ; Wnt protein</subject><ispartof>Evidence-based complementary and alternative medicine, 2017-01, Vol.2017 (2017), p.1-12</ispartof><rights>Copyright © 2017 Jun-ming Huang et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2017 Jun-ming Huang et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2017 Jun-ming Huang et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-28b5661f665c372441887ef0b03172a91636678229c1123031d2617266ae908b3</citedby><cites>FETCH-LOGICAL-c499t-28b5661f665c372441887ef0b03172a91636678229c1123031d2617266ae908b3</cites><orcidid>0000-0002-5968-4836 ; 0000-0002-6800-2788</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763109/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763109/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29445413$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Somasundaram, Indumathi</contributor><creatorcontrib>Guo, Jin-feng</creatorcontrib><creatorcontrib>Yao, Xu-dong</creatorcontrib><creatorcontrib>Guo, Jia-chao</creatorcontrib><creatorcontrib>Jing, Xing-zhi</creatorcontrib><creatorcontrib>Xiang, Wei</creatorcontrib><creatorcontrib>Bao, Yuan</creatorcontrib><creatorcontrib>Huang, Jun-ming</creatorcontrib><creatorcontrib>Wang, Rui</creatorcontrib><title>Icariin Regulates the Bidirectional Differentiation of Bone Marrow Mesenchymal Stem Cells through Canonical Wnt Signaling Pathway</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Fat infiltration within the bone marrow is easily observed in some postmenopausal women. Those fats are mainly derived from bone marrow mesenchymal stem cells (BMMSCs). The increment of adipocytes derived from BMMSCs leads to decreased osteoblasts derived from BMMSCs, so the bidirectional differentiation of BMMSCs significantly contributes to osteoporosis. Icariin is the main extractive of Herba Epimedii which is widely used in traditional Chinese medicine. In this experiment, we investigated the effect of icariin on the bidirectional differentiation of BMMSCs through quantitative real-time PCR, immunofluorescence, western blot, and tissue sections in vitro and in vivo. We found that icariin obviously promotes osteogenesis and inhibits adipogenesis through detecting staining and gene expression. Micro-CT analysis showed that icariin treatment alleviated the loss of cancellous bone of the distal femur in ovariectomized (OVX) mice. H&E staining analysis showed that icariin-treated OVX mice obtained higher bone mass and fewer bone marrow lipid droplets than OVX mice. Western blot and immunofluorescence showed that icariin regulates the bidirectional differentiation of BMMSCs via canonical Wnt signaling. This study demonstrates that icariin exerts its antiosteoporotic effect by regulating the bidirectional differentiation of BMMSCs through the canonical Wnt signaling pathway.</description><subject>Adipocytes</subject><subject>Adipogenesis</subject><subject>Bone density</subject><subject>Bone marrow</subject><subject>Bone mass</subject><subject>Bones</subject><subject>Cancellous bone</subject><subject>Computed tomography</subject><subject>Density</subject><subject>Ethylenediaminetetraacetic acid</subject><subject>Fats</subject><subject>Femur</subject><subject>Gene expression</subject><subject>Immunofluorescence</subject><subject>Kinases</subject><subject>Menopause</subject><subject>Mesenchymal stem cells</subject><subject>Mesenchyme</subject><subject>Mice</subject><subject>Mutation</subject><subject>Osteoblastogenesis</subject><subject>Osteoblasts</subject><subject>Osteogenesis</subject><subject>Osteoporosis</subject><subject>Ovariectomy</subject><subject>Post-menopause</subject><subject>Postmenopausal women</subject><subject>Rodents</subject><subject>Signal transduction</subject><subject>Staining</subject><subject>Stem cell transplantation</subject><subject>Stem cells</subject><subject>Traditional Chinese medicine</subject><subject>Wnt 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Regulates the Bidirectional Differentiation of Bone Marrow Mesenchymal Stem Cells through Canonical Wnt Signaling Pathway</title><author>Guo, Jin-feng ; Yao, Xu-dong ; Guo, Jia-chao ; Jing, Xing-zhi ; Xiang, Wei ; Bao, Yuan ; Huang, Jun-ming ; Wang, Rui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-28b5661f665c372441887ef0b03172a91636678229c1123031d2617266ae908b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adipocytes</topic><topic>Adipogenesis</topic><topic>Bone density</topic><topic>Bone marrow</topic><topic>Bone mass</topic><topic>Bones</topic><topic>Cancellous bone</topic><topic>Computed tomography</topic><topic>Density</topic><topic>Ethylenediaminetetraacetic acid</topic><topic>Fats</topic><topic>Femur</topic><topic>Gene expression</topic><topic>Immunofluorescence</topic><topic>Kinases</topic><topic>Menopause</topic><topic>Mesenchymal stem 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Indumathi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Icariin Regulates the Bidirectional Differentiation of Bone Marrow Mesenchymal Stem Cells through Canonical Wnt Signaling Pathway</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>2017</volume><issue>2017</issue><spage>1</spage><epage>12</epage><pages>1-12</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Fat infiltration within the bone marrow is easily observed in some postmenopausal women. Those fats are mainly derived from bone marrow mesenchymal stem cells (BMMSCs). The increment of adipocytes derived from BMMSCs leads to decreased osteoblasts derived from BMMSCs, so the bidirectional differentiation of BMMSCs significantly contributes to osteoporosis. Icariin is the main extractive of Herba Epimedii which is widely used in traditional Chinese medicine. In this experiment, we investigated the effect of icariin on the bidirectional differentiation of BMMSCs through quantitative real-time PCR, immunofluorescence, western blot, and tissue sections in vitro and in vivo. We found that icariin obviously promotes osteogenesis and inhibits adipogenesis through detecting staining and gene expression. Micro-CT analysis showed that icariin treatment alleviated the loss of cancellous bone of the distal femur in ovariectomized (OVX) mice. H&E staining analysis showed that icariin-treated OVX mice obtained higher bone mass and fewer bone marrow lipid droplets than OVX mice. Western blot and immunofluorescence showed that icariin regulates the bidirectional differentiation of BMMSCs via canonical Wnt signaling. This study demonstrates that icariin exerts its antiosteoporotic effect by regulating the bidirectional differentiation of BMMSCs through the canonical Wnt signaling pathway.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>29445413</pmid><doi>10.1155/2017/8085325</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-5968-4836</orcidid><orcidid>https://orcid.org/0000-0002-6800-2788</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adipocytes Adipogenesis Bone density Bone marrow Bone mass Bones Cancellous bone Computed tomography Density Ethylenediaminetetraacetic acid Fats Femur Gene expression Immunofluorescence Kinases Menopause Mesenchymal stem cells Mesenchyme Mice Mutation Osteoblastogenesis Osteoblasts Osteogenesis Osteoporosis Ovariectomy Post-menopause Postmenopausal women Rodents Signal transduction Staining Stem cell transplantation Stem cells Traditional Chinese medicine Wnt protein |
| title | Icariin Regulates the Bidirectional Differentiation of Bone Marrow Mesenchymal Stem Cells through Canonical Wnt Signaling Pathway |
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