Acetaldehyde inhibits retinoic acid biosynthesis to mediate alcohol teratogenicity

Alcohol consumption during pregnancy induces Fetal Alcohol Spectrum Disorder (FASD), which has been proposed to arise from competitive inhibition of retinoic acid (RA) biosynthesis. We provide biochemical and developmental evidence identifying acetaldehyde as responsible for this inhibition. In the...

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Veröffentlicht in:	Scientific reports 2018-01, Vol.8 (1), p.347, Article 347
Hauptverfasser:	Shabtai, Yehuda, Bendelac, Liat, Jubran, Halim, Hirschberg, Joseph, Fainsod, Abraham
Format:	Artikel
Sprache:	eng
Schlagworte:	38/77 38/90 631/136/1425 64 64/114 692/4017 82/80 82/83 96 96/95 Acetaldehyde Acetaldehyde - pharmacology Alcohol Alcohol dehydrogenase Alcohol Dehydrogenase - metabolism Animals Biosynthesis Biosynthetic Pathways - drug effects Dehydrogenase Dehydrogenases Embryos Ethanol Ethanol - adverse effects Ethanol - metabolism Fetal alcohol syndrome Gene Expression Regulation - drug effects Humanities and Social Sciences Models, Biological multidisciplinary Oxidation Pregnancy Retinal Dehydrogenase - metabolism Retinaldehyde Retinaldehyde dehydrogenase Retinoic acid Science Science (multidisciplinary) Teratogenicity Teratogens - metabolism Tretinoin - metabolism Xenopus
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