β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson’s disease

Copy number mutations implicate excess production of α-synuclein as a possibly causative factor in Parkinson’s disease (PD). Using an unbiased screen targeting endogenous gene expression, we discovered that the β2-adrenoreceptor (β2AR) is a regulator of the α-synuclein gene (SNCA). β2AR ligands modu...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 2017-09, Vol.357 (6354), p.891-898
Hauptverfasser:	Mittal, Shuchi, Bjørnevik, Kjetil, Im, Doo Soon, Flierl, Adrian, Dong, Xianjun, Locascio, Joseph J., Abo, Kristine M., Long, Elizabeth, Jin, Ming, Xu, Bing, Xiang, Yang K., Rochet, Jean-Christophe, Engeland, Anders, Rizzu, Patrizia, Heutink, Peter, Bartels, Tim, Selkoe, Dennis J., Caldarone, Barbara J., Glicksman, Marcie A., Khurana, Vikram, Schüle, Birgitt, Park, David S., Riise, Trond, Scherzer, Clemens R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Adrenergic beta-1 Receptor Agonists - pharmacology Adrenergic beta-Antagonists - pharmacology Adrenergic beta-Antagonists - therapeutic use Albuterol - pharmacology Albuterol - therapeutic use alpha-Synuclein - genetics Animals Cell Line, Tumor Enhancer Elements, Genetic Gene Expression Regulation - drug effects Histones - metabolism Humans Ligands Mice Neuroprotective Agents - pharmacology Norway - ethnology Parkinson Disease - drug therapy Parkinson Disease - ethnology Parkinson Disease - genetics Promoter Regions, Genetic Propranolol - pharmacology Propranolol - therapeutic use Receptors, Adrenergic, beta-2 - genetics Receptors, Adrenergic, beta-2 - metabolism Risk Substantia Nigra - metabolism Transcription, Genetic - drug effects
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