Prediction of cognition in Parkinson's disease with a clinical–genetic score: a longitudinal analysis of nine cohorts

Summary Background Cognitive decline is a debilitating manifestation of disease progression in Parkinson's disease. We aimed to develop a clinical–genetic score to predict global cognitive impairment in patients with the disease. Methods In this longitudinal analysis, we built a prediction algo...

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Veröffentlicht in:	Lancet neurology 2017-08, Vol.16 (8), p.620-629
Hauptverfasser:	Liu, Ganqiang, PhD, Locascio, Joseph J, PhD, Corvol, Jean-Christophe, Prof, Boot, Brendon, MBBS, Liao, Zhixiang, MS, Page, Kara, BS, Franco, Daly, BA, Burke, Kyle, BS, Jansen, Iris E, MS, Trisini-Lipsanopoulos, Ana, BS, Winder-Rhodes, Sophie, PhD, Tanner, Caroline M, Prof, Lang, Anthony E, Prof, Eberly, Shirley, MS, Elbaz, Alexis, Prof, Brice, Alexis, Prof, Mangone, Graziella, MD, Ravina, Bernard, MD, Shoulson, Ira, Prof, Cormier-Dequaire, Florence, MD, Heutink, Peter, Prof, van Hilten, Jacobus J, Prof, Barker, Roger A, Prof, Williams-Gray, Caroline H, PhD, Marinus, Johan, PhD, Scherzer, Clemens R, Dr
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Aged Aged, 80 and over Algorithms Biomarkers Cardiovascular disease Clinical trials Cognitive ability Cognitive Dysfunction Cognitive Dysfunction - diagnosis Cognitive Dysfunction - etiology Dementia Dementia - diagnosis Dementia - etiology Dementia disorders Disease Progression Female Genes Glucosylceramidase Health risk assessment Humans Life Sciences Longitudinal Studies Male Medical prognosis Middle Aged Motor task performance Movement disorders Mutation Neurodegenerative diseases Neurology Neurons and Cognition Parkinson Disease Parkinson Disease - complications Parkinson Disease - diagnosis Parkinson's disease Patients Population studies Prognosis Proportional Hazards Models Replication Task forces
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