Modulation of Ether-à-Go-Go Related Gene (ERG) Current Governs Intrinsic Persistent Activity in Rodent Neocortical Pyramidal Cells

While cholinergic receptor activation has long been known to dramatically enhance the excitability of cortical neurons, the cellular mechanisms responsible for this effect are not well understood. We used intracellular recordings in rat (both sexes) neocortical brain slices to assess the ionic mecha...

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Veröffentlicht in:	The Journal of neuroscience 2018-01, Vol.38 (2), p.423-440
Hauptverfasser:	Cui, Edward D, Strowbridge, Ben W
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine receptors Action Potentials - physiology Activation Animals Brain Brain slice preparation Calcium Channels Cognitive ability Depolarization Electroretinograms Ether-A-Go-Go Potassium Channels - metabolism Excitability Female Firing pattern Intracellular Male Membrane potential Memory Mental disorders Modulation Mutation Neocortex - physiology Neurons Organic chemistry Potassium Pyramidal cells Pyramidal Cells - metabolism Rats Rats, Sprague-Dawley Receptor mechanisms Reduction Schizophrenia Short term memory Stimuli Terfenadine
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