Release test of alliin/alliinase double-layer tablet by HPLC Allicin determination
A simple, precise and accurate method was developed and validated for the determination of allicin release from alliin/alliinase double-layer tablets. According to Appendix XC Ⅱ of Chinese Pharmacopoeia 2010 edition Volume II, a small glass-method was adopted at the rotational speed of 100 r/min usi...
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| Veröffentlicht in: | Journal of pharmaceutical analysis 2013-06, Vol.3 (3), p.187-192 |
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| container_title | Journal of pharmaceutical analysis |
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| creator | Liang, Yan Zhang, Jing-Jing Zhang, Qi-Bing Wang, Zhong-Xia Yin, Zong-Ning Li, Xin-Xia Chen, Jian Ye, Li-Ming |
| description | A simple, precise and accurate method was developed and validated for the determination of allicin release from alliin/alliinase double-layer tablets. According to Appendix XC Ⅱ of Chinese Pharmacopoeia 2010 edition Volume II, a small glass-method was adopted at the rotational speed of 100 r/min using 100 mL phosphate buffer （pH 6.8） as release medium. The release amount was determined by HPLC with a C18 column （250 mm × 4.6 mm, 5 μm） using the mobile phase consisting of methanol -0.4% carboxylic acid （65：35） at a flow rate of 1 mL/min and UV detection at 242 nm. The current method demonstrates good linearity over the range 4.052- 405.2 μg/mL （r2=0.9999） with an average recovery of 105.5%（RSD= 1.25%）. The accumulative release of alliin/alliinase double-layer tablets had good homogeneity for withinand betweenbatches. The method established is simple, accurate and repeatable for the determination of allicin release from alliin/alliinase double-layer tablets. |
| doi_str_mv | 10.1016/j.jpha.2012.08.001 |
| format | Article |
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According to Appendix XC Ⅱ of Chinese Pharmacopoeia 2010 edition Volume II, a small glass-method was adopted at the rotational speed of 100 r/min using 100 mL phosphate buffer （pH 6.8） as release medium. The release amount was determined by HPLC with a C18 column （250 mm × 4.6 mm, 5 μm） using the mobile phase consisting of methanol -0.4% carboxylic acid （65：35） at a flow rate of 1 mL/min and UV detection at 242 nm. The current method demonstrates good linearity over the range 4.052- 405.2 μg/mL （r2=0.9999） with an average recovery of 105.5%（RSD= 1.25%）. The accumulative release of alliin/alliinase double-layer tablets had good homogeneity for withinand betweenbatches. The method established is simple, accurate and repeatable for the determination of allicin release from alliin/alliinase double-layer tablets.</description><identifier>ISSN: 2095-1779</identifier><identifier>EISSN: 2214-0883</identifier><identifier>DOI: 10.1016/j.jpha.2012.08.001</identifier><identifier>PMID: 29403815</identifier><language>eng</language><publisher>China: Elsevier B.V</publisher><subject>Allicin ; Alliin/alliinase ; Double-layer tablet ; HPLC ; Release test ; 大蒜素 ; 层片 ; 测定 ; 磷酸盐缓冲液 ; 蒜氨酸 ; 蒜酶 ; 释放试验 ; 高效液相色谱法</subject><ispartof>Journal of pharmaceutical analysis, 2013-06, Vol.3 (3), p.187-192</ispartof><rights>2013 Xi'an Jiaotong University</rights><rights>Copyright © Wanfang Data Co. Ltd. All Rights Reserved.</rights><rights>2013 Xi’an Jiaotong University. Production and hosting by Elsevier B.V. 2013 Xi'an Jiaotong University</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c655t-4021859abbdba463d5b47a819ab599b3f763b1a99c7fae1dcd3ba48a602badb73</citedby><cites>FETCH-LOGICAL-c655t-4021859abbdba463d5b47a819ab599b3f763b1a99c7fae1dcd3ba48a602badb73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://image.cqvip.com/vip1000/qk/71198X/71198X.jpg</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760948/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760948/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29403815$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liang, Yan</creatorcontrib><creatorcontrib>Zhang, Jing-Jing</creatorcontrib><creatorcontrib>Zhang, Qi-Bing</creatorcontrib><creatorcontrib>Wang, Zhong-Xia</creatorcontrib><creatorcontrib>Yin, Zong-Ning</creatorcontrib><creatorcontrib>Li, Xin-Xia</creatorcontrib><creatorcontrib>Chen, Jian</creatorcontrib><creatorcontrib>Ye, Li-Ming</creatorcontrib><title>Release test of alliin/alliinase double-layer tablet by HPLC Allicin determination</title><title>Journal of pharmaceutical analysis</title><addtitle>J Pharm Anal</addtitle><description>A simple, precise and accurate method was developed and validated for the determination of allicin release from alliin/alliinase double-layer tablets. According to Appendix XC Ⅱ of Chinese Pharmacopoeia 2010 edition Volume II, a small glass-method was adopted at the rotational speed of 100 r/min using 100 mL phosphate buffer （pH 6.8） as release medium. The release amount was determined by HPLC with a C18 column （250 mm × 4.6 mm, 5 μm） using the mobile phase consisting of methanol -0.4% carboxylic acid （65：35） at a flow rate of 1 mL/min and UV detection at 242 nm. The current method demonstrates good linearity over the range 4.052- 405.2 μg/mL （r2=0.9999） with an average recovery of 105.5%（RSD= 1.25%）. The accumulative release of alliin/alliinase double-layer tablets had good homogeneity for withinand betweenbatches. The method established is simple, accurate and repeatable for the determination of allicin release from alliin/alliinase double-layer tablets.</description><subject>Allicin</subject><subject>Alliin/alliinase</subject><subject>Double-layer tablet</subject><subject>HPLC</subject><subject>Release test</subject><subject>大蒜素</subject><subject>层片</subject><subject>测定</subject><subject>磷酸盐缓冲液</subject><subject>蒜氨酸</subject><subject>蒜酶</subject><subject>释放试验</subject><subject>高效液相色谱法</subject><issn>2095-1779</issn><issn>2214-0883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9UU1v1DAQjRCIVqV_gAMKNzgkteM4tiWEVK2AIq0EquBs-WOy6yhrb-2k7f57vMq2ggu-zMjz5s3Me0XxFqMaI9xdDfWw36q6QbipEa8Rwi-K86bBbYU4Jy9zjgStMGPirLhMaUD5MdRwQV8XZ41oEeGYnhe3tzCCSlBOkKYy9KUaR-f81RKOBRtmPUI1qgPEclI5n0p9KG9-rlfldUYZ50sLE8Rdxk8u-DfFq16NCS5P8aL4_fXLr9VNtf7x7fvqel2ZjtKpalGDORVKa6tV2xFLdcsUx_mHCqFJzzqisRLCsF4BtsaSjOOqQ41WVjNyUXxeePez3oE14KeoRrmPbqfiQQbl5L8V77ZyE-4lZR0SLc8EHxeCB-V75TdyCHP0eWV5eOgfH7WErC5BBKEuYz-chsVwN2et5M4lA-OoPIQ5SSwExW2HGMnQZoGaGFKK0D-vhJE8eicHefROHr2TiMvsXW569_cxzy1PTmXApwUAWdJ7B1Em48AbsC6CmaQN7v_8709LbYPf3Ll87dOIrD1pWVb7D9j4twg</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Liang, Yan</creator><creator>Zhang, Jing-Jing</creator><creator>Zhang, Qi-Bing</creator><creator>Wang, Zhong-Xia</creator><creator>Yin, Zong-Ning</creator><creator>Li, Xin-Xia</creator><creator>Chen, Jian</creator><creator>Ye, Li-Ming</creator><general>Elsevier B.V</general><general>West China School of Pharmacy, Sichuan University, Chengdu 610041, China%Xinjiang Medical University, Wulumuqi 830000, China</general><general>Xi'an Jiaotong University</general><scope>2RA</scope><scope>92L</scope><scope>CQIGP</scope><scope>W91</scope><scope>~WA</scope><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>2B.</scope><scope>4A8</scope><scope>92I</scope><scope>93N</scope><scope>PSX</scope><scope>TCJ</scope><scope>5PM</scope></search><sort><creationdate>20130601</creationdate><title>Release test of alliin/alliinase double-layer tablet by HPLC Allicin determination</title><author>Liang, Yan ; Zhang, Jing-Jing ; Zhang, Qi-Bing ; Wang, Zhong-Xia ; Yin, Zong-Ning ; Li, Xin-Xia ; Chen, Jian ; Ye, Li-Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c655t-4021859abbdba463d5b47a819ab599b3f763b1a99c7fae1dcd3ba48a602badb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Allicin</topic><topic>Alliin/alliinase</topic><topic>Double-layer tablet</topic><topic>HPLC</topic><topic>Release test</topic><topic>大蒜素</topic><topic>层片</topic><topic>测定</topic><topic>磷酸盐缓冲液</topic><topic>蒜氨酸</topic><topic>蒜酶</topic><topic>释放试验</topic><topic>高效液相色谱法</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liang, Yan</creatorcontrib><creatorcontrib>Zhang, Jing-Jing</creatorcontrib><creatorcontrib>Zhang, Qi-Bing</creatorcontrib><creatorcontrib>Wang, Zhong-Xia</creatorcontrib><creatorcontrib>Yin, Zong-Ning</creatorcontrib><creatorcontrib>Li, Xin-Xia</creatorcontrib><creatorcontrib>Chen, Jian</creatorcontrib><creatorcontrib>Ye, Li-Ming</creatorcontrib><collection>中文科技期刊数据库</collection><collection>中文科技期刊数据库-CALIS站点</collection><collection>中文科技期刊数据库-7.0平台</collection><collection>中文科技期刊数据库-医药卫生</collection><collection>中文科技期刊数据库- 镜像站点</collection><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Wanfang Data Journals - Hong Kong</collection><collection>WANFANG Data Centre</collection><collection>Wanfang Data Journals</collection><collection>万方数据期刊 - 香港版</collection><collection>China Online Journals (COJ)</collection><collection>China Online Journals (COJ)</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of pharmaceutical analysis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liang, Yan</au><au>Zhang, Jing-Jing</au><au>Zhang, Qi-Bing</au><au>Wang, Zhong-Xia</au><au>Yin, Zong-Ning</au><au>Li, Xin-Xia</au><au>Chen, Jian</au><au>Ye, Li-Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Release test of alliin/alliinase double-layer tablet by HPLC Allicin determination</atitle><jtitle>Journal of pharmaceutical analysis</jtitle><addtitle>J Pharm Anal</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>3</volume><issue>3</issue><spage>187</spage><epage>192</epage><pages>187-192</pages><issn>2095-1779</issn><eissn>2214-0883</eissn><abstract>A simple, precise and accurate method was developed and validated for the determination of allicin release from alliin/alliinase double-layer tablets. According to Appendix XC Ⅱ of Chinese Pharmacopoeia 2010 edition Volume II, a small glass-method was adopted at the rotational speed of 100 r/min using 100 mL phosphate buffer （pH 6.8） as release medium. The release amount was determined by HPLC with a C18 column （250 mm × 4.6 mm, 5 μm） using the mobile phase consisting of methanol -0.4% carboxylic acid （65：35） at a flow rate of 1 mL/min and UV detection at 242 nm. The current method demonstrates good linearity over the range 4.052- 405.2 μg/mL （r2=0.9999） with an average recovery of 105.5%（RSD= 1.25%）. The accumulative release of alliin/alliinase double-layer tablets had good homogeneity for withinand betweenbatches. The method established is simple, accurate and repeatable for the determination of allicin release from alliin/alliinase double-layer tablets.</abstract><cop>China</cop><pub>Elsevier B.V</pub><pmid>29403815</pmid><doi>10.1016/j.jpha.2012.08.001</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Allicin Alliin/alliinase Double-layer tablet HPLC Release test 大蒜素 层片 测定 磷酸盐缓冲液 蒜氨酸 蒜酶 释放试验 高效液相色谱法 |
| title | Release test of alliin/alliinase double-layer tablet by HPLC Allicin determination |
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