Brucella abortus Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation

Immunity against microbes depends on recognition of pathogen-associated molecular patterns by innate receptors. Signaling pathways triggered by DNA involves TLR9, AIM2, and stimulator of IFN genes (STING). In this study, we observed by microarray analysis that several type I IFN-associated genes, su...

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Veröffentlicht in:	The Journal of immunology (1950) 2018-01, Vol.200 (2), p.607-622
Hauptverfasser:	Costa Franco, Miriam M, Marim, Fernanda, Guimarães, Erika S, Assis, Natan R G, Cerqueira, Daiane M, Alves-Silva, Juliana, Harms, Jerome, Splitter, Gary, Smith, Judith, Kanneganti, Thirumala-Devi, de Queiroz, Nina M G P, Gutman, Delia, Barber, Glen N, Oliveira, Sergio C
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation AMP Animals Bacteria Bacterial infections Brucella Brucella abortus Brucella abortus - genetics Brucella abortus - immunology Brucellosis - genetics Brucellosis - immunology Brucellosis - metabolism Brucellosis - microbiology Caspase Caspase-1 Cell activation Cyclic GMP Cyclic GMP - analogs & derivatives Cyclic GMP - metabolism Cytokines - metabolism Cytosol Deoxyribonucleic acid DNA DNA microarrays Gene Expression Gene Expression Profiling Genes Granuloma - metabolism Granuloma - microbiology Granuloma - pathology GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism Host-Pathogen Interactions - genetics Host-Pathogen Interactions - immunology IL-1β Immunity, Innate Infections Inflammasomes Inflammasomes - metabolism Inflammation Mediators Interferon regulatory factor 1 Interferon Regulatory Factor-3 - metabolism Interferon Type I - genetics Interferon Type I - metabolism Macrophages Macrophages - immunology Macrophages - metabolism Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Knockout Models, Biological NF-kappa B - metabolism Proteins Secretion Signal Transduction siRNA Stimulators TLR9 protein Toll-like receptors β-Interferon
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