Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function

Thyroid hormone improves mitochondrial function and dynamics in lung epithelium to reduce pulmonary fibrosis in mice. Thyroid hormone (TH) is critical for the maintenance of cellular homeostasis during stress responses, but its role in lung fibrosis is unknown. Here we found that the activity and ex...

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Veröffentlicht in:	Nature medicine 2018-01, Vol.24 (1), p.39-49
Hauptverfasser:	Yu, Guoying, Tzouvelekis, Argyris, Wang, Rong, Herazo-Maya, Jose D, Ibarra, Gabriel H, Srivastava, Anup, de Castro, Joao Pedro Werneck, DeIuliis, Giuseppe, Ahangari, Farida, Woolard, Tony, Aurelien, Nachelle, Arrojo e Drigo, Rafael, Gan, Ye, Graham, Morven, Liu, Xinran, Homer, Robert J, Scanlan, Thomas S, Mannam, Praveen, Lee, Patty J, Herzog, Erica L, Bianco, Antonio C, Kaminski, Naftali
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/2 38 38/39 38/61 631/154/152 631/154/555 64 64/60 692/699/1785 Alveoli Analysis Animal models Animals Apoptosis Bioenergetics Biomedicine Bleomycin Cancer Research Cells, Cultured Disease control Epithelial cells Epithelium - physiology Female Fibrosis Homeostasis House mouse Humans Infectious Diseases Iodide peroxidase Iodide Peroxidase - genetics Iodothyronine Deiodinase Type II Lung diseases Lungs Metabolic Diseases Mice Mice, Inbred C57BL Mice, Knockout Mitochondria Mitochondria - physiology Mitochondrial biogenesis Molecular Medicine Molecular Mimicry Neurosciences Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha - genetics Physiological aspects Prevention Protein Kinases - genetics PTEN-induced putative kinase Pulmonary fibrosis Pulmonary Fibrosis - physiopathology Pulmonary Fibrosis - prevention & control Restoration Rodents Thyroid Thyroid gland Thyroid hormones Thyroid Hormones - physiology Thyroxine deiodinase Trachea Transforming growth factor-b1
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