Gadoterate meglumine decreases ADC values of breast lesions depending on the b value combination
To retrospectively evaluated the influence of administration of the gadolinium based intravenous contrast agent (G-CA) on apparent diffusion coefficient (ADC) values in ADC maps generated using multiple b value combinations. A total of 106 women underwent bilateral 3.0 T breast MRI. As an internal v...
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| Veröffentlicht in: | Scientific reports 2018-01, Vol.8 (1), p.87-87, Article 87 |
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| description | To retrospectively evaluated the influence of administration of the gadolinium based intravenous contrast agent (G-CA) on apparent diffusion coefficient (ADC) values in ADC maps generated using multiple b value combinations. A total of 106 women underwent bilateral 3.0 T breast MRI. As an internal validation, diffusion-weighted imaging (b values of 0, 200, 400, 600, 800 s/mm
2
) was performed before and after the G-CA (gadoterate meglumine (0.2 ml/kg, 3 ml/s)). Whole lesion and fibroglandular tissue (FGT) covering region-of-interests (ROIs) were drawn on the b = 800 s/mm
2
images; ROIs were then propagated to multiple retrospectively generated ADC maps. Twenty-seven patients (mean age 55.8 ± 10.8 years) with 32 mass-like enhancing breast lesions including 25 (78.1 %) histopathologically malignant lesions were enrolled. Lesion ADC values were statistically significantly higher in pre-G-CA than post-G-CA ADC maps (ADC
0,200,400,600,800
: 1.05 ± 0.35 × 10
−3
mm
2
/s vs. 1.02 ± 0.36 × 10
−3
mm
2
/s (
P
|
| doi_str_mv | 10.1038/s41598-017-18035-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5758819</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1989558249</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-6adf016b14e06cdf03fdbecf1aebbc5dafbb20502e93b91b4108c156bfe3ead3</originalsourceid><addsrcrecordid>eNp1kU9v1DAQxS0EolXpF-CALHHhkuLxn419QaoWKEiVuPRubGeyTZXYi51U6rfHS9pqQcIXjzy_eeOnR8hbYBfAhP5YJCijGwZtA5oJ1bAX5JQzqRouOH95VJ-Q81LuWD2KGwnmNTnhRgC0zJySn1euSzNmNyOdcDcu0xCRdhgyuoKFXn7e0ns3LrVMPfWH15mOWIYUS8X2GLsh7miKdL5F6leWhjT5Ibq5Um_Iq96NBc8f7zNy8_XLzfZbc_3j6vv28roJspVzs3Fdz2DjQSLbhFqLvvMYenDofVCd673nTDGORngDXgLTAdTG9yjQdeKMfFpl94ufsAsY5-xGu8_D5PKDTW6wf3ficGt36d6qVmkNpgp8eBTI6Ve1O9tpKAHH0UVMS7FgtFFKc3lA3_-D3qUlx-quUkZIaAXoSvGVCjmVkrF__gwwe4jQrhHaGqH9E6FldejdsY3nkafAKiBWoNRW3GE-2v1_2d_a-Klx</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1993417318</pqid></control><display><type>article</type><title>Gadoterate meglumine decreases ADC values of breast lesions depending on the b value combination</title><source>Nature Free</source><source>DOAJ Directory of Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>Free Full-Text Journals in Chemistry</source><source>Springer Nature OA Free Journals</source><creator>Arponen, Otso ; Sudah, Mazen ; Sutela, Anna ; Taina, Mikko ; Masarwah, Amro ; Liimatainen, Timo ; Vanninen, Ritva</creator><creatorcontrib>Arponen, Otso ; Sudah, Mazen ; Sutela, Anna ; Taina, Mikko ; Masarwah, Amro ; Liimatainen, Timo ; Vanninen, Ritva</creatorcontrib><description>To retrospectively evaluated the influence of administration of the gadolinium based intravenous contrast agent (G-CA) on apparent diffusion coefficient (ADC) values in ADC maps generated using multiple b value combinations. A total of 106 women underwent bilateral 3.0 T breast MRI. As an internal validation, diffusion-weighted imaging (b values of 0, 200, 400, 600, 800 s/mm
2
) was performed before and after the G-CA (gadoterate meglumine (0.2 ml/kg, 3 ml/s)). Whole lesion and fibroglandular tissue (FGT) covering region-of-interests (ROIs) were drawn on the b = 800 s/mm
2
images; ROIs were then propagated to multiple retrospectively generated ADC maps. Twenty-seven patients (mean age 55.8 ± 10.8 years) with 32 mass-like enhancing breast lesions including 25 (78.1 %) histopathologically malignant lesions were enrolled. Lesion ADC values were statistically significantly higher in pre-G-CA than post-G-CA ADC maps (ADC
0,200,400,600,800
: 1.05 ± 0.35 × 10
−3
mm
2
/s vs. 1.02 ± 0.36 × 10
−3
mm
2
/s (
P
< 0.05); ADC
0,200,400
: 1.25 ± 0.42 × 10
−3
mm
2
/s vs. 1.20 ± 0.35 × 10
−3
mm
2
/s (
P
< 0.05)). ADC values between pre- and post-contrast maps were not statistically different when the maps were generated using other b value combinations. Contrast agent administration did not affect the FGT ADC values. G-CA statistically significantly reduced the ADC values of breast lesions on ADC maps generated using the clinically widely utilized b values.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-017-18035-0</identifier><identifier>PMID: 29311709</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>59 ; 59/57 ; 692/308 ; 692/308/575 ; Biopsy ; Breast ; Diffusion coefficient ; Gadolinium ; Humanities and Social Sciences ; Intravenous administration ; Lesions ; Magnetic resonance imaging ; multidisciplinary ; Science ; Science (multidisciplinary)</subject><ispartof>Scientific reports, 2018-01, Vol.8 (1), p.87-87, Article 87</ispartof><rights>The Author(s) 2017</rights><rights>2017. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-6adf016b14e06cdf03fdbecf1aebbc5dafbb20502e93b91b4108c156bfe3ead3</citedby><cites>FETCH-LOGICAL-c474t-6adf016b14e06cdf03fdbecf1aebbc5dafbb20502e93b91b4108c156bfe3ead3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758819/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758819/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29311709$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arponen, Otso</creatorcontrib><creatorcontrib>Sudah, Mazen</creatorcontrib><creatorcontrib>Sutela, Anna</creatorcontrib><creatorcontrib>Taina, Mikko</creatorcontrib><creatorcontrib>Masarwah, Amro</creatorcontrib><creatorcontrib>Liimatainen, Timo</creatorcontrib><creatorcontrib>Vanninen, Ritva</creatorcontrib><title>Gadoterate meglumine decreases ADC values of breast lesions depending on the b value combination</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>To retrospectively evaluated the influence of administration of the gadolinium based intravenous contrast agent (G-CA) on apparent diffusion coefficient (ADC) values in ADC maps generated using multiple b value combinations. A total of 106 women underwent bilateral 3.0 T breast MRI. As an internal validation, diffusion-weighted imaging (b values of 0, 200, 400, 600, 800 s/mm
2
) was performed before and after the G-CA (gadoterate meglumine (0.2 ml/kg, 3 ml/s)). Whole lesion and fibroglandular tissue (FGT) covering region-of-interests (ROIs) were drawn on the b = 800 s/mm
2
images; ROIs were then propagated to multiple retrospectively generated ADC maps. Twenty-seven patients (mean age 55.8 ± 10.8 years) with 32 mass-like enhancing breast lesions including 25 (78.1 %) histopathologically malignant lesions were enrolled. Lesion ADC values were statistically significantly higher in pre-G-CA than post-G-CA ADC maps (ADC
0,200,400,600,800
: 1.05 ± 0.35 × 10
−3
mm
2
/s vs. 1.02 ± 0.36 × 10
−3
mm
2
/s (
P
< 0.05); ADC
0,200,400
: 1.25 ± 0.42 × 10
−3
mm
2
/s vs. 1.20 ± 0.35 × 10
−3
mm
2
/s (
P
< 0.05)). ADC values between pre- and post-contrast maps were not statistically different when the maps were generated using other b value combinations. Contrast agent administration did not affect the FGT ADC values. G-CA statistically significantly reduced the ADC values of breast lesions on ADC maps generated using the clinically widely utilized b values.</description><subject>59</subject><subject>59/57</subject><subject>692/308</subject><subject>692/308/575</subject><subject>Biopsy</subject><subject>Breast</subject><subject>Diffusion coefficient</subject><subject>Gadolinium</subject><subject>Humanities and Social Sciences</subject><subject>Intravenous administration</subject><subject>Lesions</subject><subject>Magnetic resonance imaging</subject><subject>multidisciplinary</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU9v1DAQxS0EolXpF-CALHHhkuLxn419QaoWKEiVuPRubGeyTZXYi51U6rfHS9pqQcIXjzy_eeOnR8hbYBfAhP5YJCijGwZtA5oJ1bAX5JQzqRouOH95VJ-Q81LuWD2KGwnmNTnhRgC0zJySn1euSzNmNyOdcDcu0xCRdhgyuoKFXn7e0ns3LrVMPfWH15mOWIYUS8X2GLsh7miKdL5F6leWhjT5Ibq5Um_Iq96NBc8f7zNy8_XLzfZbc_3j6vv28roJspVzs3Fdz2DjQSLbhFqLvvMYenDofVCd673nTDGORngDXgLTAdTG9yjQdeKMfFpl94ufsAsY5-xGu8_D5PKDTW6wf3ficGt36d6qVmkNpgp8eBTI6Ve1O9tpKAHH0UVMS7FgtFFKc3lA3_-D3qUlx-quUkZIaAXoSvGVCjmVkrF__gwwe4jQrhHaGqH9E6FldejdsY3nkafAKiBWoNRW3GE-2v1_2d_a-Klx</recordid><startdate>20180108</startdate><enddate>20180108</enddate><creator>Arponen, Otso</creator><creator>Sudah, Mazen</creator><creator>Sutela, Anna</creator><creator>Taina, Mikko</creator><creator>Masarwah, Amro</creator><creator>Liimatainen, Timo</creator><creator>Vanninen, Ritva</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20180108</creationdate><title>Gadoterate meglumine decreases ADC values of breast lesions depending on the b value combination</title><author>Arponen, Otso ; 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A total of 106 women underwent bilateral 3.0 T breast MRI. As an internal validation, diffusion-weighted imaging (b values of 0, 200, 400, 600, 800 s/mm
2
) was performed before and after the G-CA (gadoterate meglumine (0.2 ml/kg, 3 ml/s)). Whole lesion and fibroglandular tissue (FGT) covering region-of-interests (ROIs) were drawn on the b = 800 s/mm
2
images; ROIs were then propagated to multiple retrospectively generated ADC maps. Twenty-seven patients (mean age 55.8 ± 10.8 years) with 32 mass-like enhancing breast lesions including 25 (78.1 %) histopathologically malignant lesions were enrolled. Lesion ADC values were statistically significantly higher in pre-G-CA than post-G-CA ADC maps (ADC
0,200,400,600,800
: 1.05 ± 0.35 × 10
−3
mm
2
/s vs. 1.02 ± 0.36 × 10
−3
mm
2
/s (
P
< 0.05); ADC
0,200,400
: 1.25 ± 0.42 × 10
−3
mm
2
/s vs. 1.20 ± 0.35 × 10
−3
mm
2
/s (
P
< 0.05)). ADC values between pre- and post-contrast maps were not statistically different when the maps were generated using other b value combinations. Contrast agent administration did not affect the FGT ADC values. G-CA statistically significantly reduced the ADC values of breast lesions on ADC maps generated using the clinically widely utilized b values.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>29311709</pmid><doi>10.1038/s41598-017-18035-0</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| subjects | 59 59/57 692/308 692/308/575 Biopsy Breast Diffusion coefficient Gadolinium Humanities and Social Sciences Intravenous administration Lesions Magnetic resonance imaging multidisciplinary Science Science (multidisciplinary) |
| title | Gadoterate meglumine decreases ADC values of breast lesions depending on the b value combination |
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